Effect of guanethidine and bretylium tosylate on systemic and renal hemodynamics in essential hypertension

Villarreal, H; Exaire, J. Emilio; Rubio, Víctor J.; Davila, Hugo H.

doi:10.1016/0002-9149(64)90054-2

Cited by 27 publications

(8 citation statements)

References 10 publications

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“…Peripheral resistance was not changed but there was a substantial reduction in cardiac output (COHN et aI., 1963;BREST, 1965). If the patients were tilted, blood pressure and cardiac output were further reduced and systemic resistance fell (VILLARREAL, 1964). Vasoconstrictor reflexes were inhibited (WILSON et aI., 1960;TAYLOR et aI., 1962;COHN et aI., 1963).…”

Section: Therapeutic Use In Hypertensionmentioning

confidence: 99%

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Adrenergic Neuron Blocking Drugs

Maxwell¹,

Wastila²

1977

Antihypertensive Agents

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Section: Therapeutic Use In Hypertensionmentioning

confidence: 99%

“…In longer-term therapy, cardiac output was not lowered in either the recumbent or standing position and systemic vascular resistance and heart rate were reduced (C1rAMBERLAIN and HOWARD, 1964;VILLARREAL et al, 1964).…”

Section: -------------------------------mentioning

confidence: 99%

Adrenergic Neuron Blocking Drugs

Maxwell¹,

Wastila²

1977

Antihypertensive Agents

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“…In the case of guanethidine (81,82,88). but not bretylium (88), the increase in peripheral resistance which usually accompanies the tilt is partially abolished. Pargyline and a-methyldopa also produce a further blood pressure reduction in an upright position, but the effect does not appear to be related to venous pooling.…”

Section: Herrlodynamics Of Hypertensionmentioning

confidence: 91%

“…This appears to be the result of a further reduction in cardiac output (73,74,81,82,88,127). In the case of guanethidine (81,82,88). but not bretylium (88), the increase in peripheral resistance which usually accompanies the tilt is partially abolished.…”

Section: Herrlodynamics Of Hypertensionmentioning

confidence: 95%

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The Hemodynamics of Hypertension and Anti Hypertensive Therapy

Bender¹

1966

Angiology

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It has been amply demonstrated that lowering systemic arterial pressure betters the prognosis of patients with hypertension. When the cause of the hypertension is known, the treatment of choice is the removal of the lesion. If the pathogenesis of the blood pressure elevation is unknown, however, treatment must necessarily be empirical and irrational. Despite this approach there is general agreement that controlling blood pressure with antihypertensive drugs results in a longer life expectancy for patients with essential hypertension and a reduction in the incidence of associated disabling cardiac, cerebrovascular, and renal complications (1, 2). HerrLOdynamics of hypertensionWhile there are some exceptions, especially in its early stages (3, 4), essential hypertension is associated with an increase in peripheral vascular resistance with a normal cardiac output (5-7). The cause of the elevation does not appear to be the result of increased sympathetic tone, but rather a narrowing of the resistance vessels brought about by progressive arteriosclerosis and, occasionally, degenerative changes in elastic tissue (5).Initially, it was suggested that each of the major vascular beds, with the exception of the kidney, contributed equally to the elevation in peripheral resistance. In the kidney resistance is slightly more intense, with the result that renal plasma flow is moderately reduced (8-10). On the other hand cerebral blood flow (11, 12), coronary blood flow (13), and hepatic blood flow (14,15) are within normal limits.The results of other studies (7, 16) indicate that the vasculature of skeletal muscle does not share in the increased resistance. Furthermore, the results suggest a parallel between the hemodynamic pattern of hypertension and that exhibited by normal subjects during mild exercise. In view of the unchanged cardiac output (7) and the increase in skeletal muscle flow, the results imply a reduction in flow to other major vascular beds.Objectives of antihyperten,sive therapy The primary objective of antihypertensive therapy is, of course, to reduce arterial blood pressure. It is equally apparent that it is desirable to decrease blood pressure by a mechanism which causes little or no compromise of cardiovascular function. From the examination of the relationship Blood pressure = peripheral vascular resistance X cardiac output at The University of Iowa Libraries on June 20, 2015 ang.sagepub.com Downloaded from

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Inhibition of Adrenergic Function in the Treatment of Hypertension

Fröhlich¹

1974

Arch Intern Med

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Effect of guanethidine and bretylium tosylate on systemic and renal hemodynamics in essential hypertension

Cited by 27 publications

References 10 publications

Adrenergic Neuron Blocking Drugs

Adrenergic Neuron Blocking Drugs

The Hemodynamics of Hypertension and Anti Hypertensive Therapy

Inhibition of Adrenergic Function in the Treatment of Hypertension

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