Effect of GST variants on lung function following diesel exhaust and allergen co-exposure in a controlled human crossover study

Zhang, Xin; Hirota, Jeremy A.; Yang, Chenxi; Carlsten, Chris

doi:10.1016/j.freeradbiomed.2016.04.202

Cited by 23 publications

(19 citation statements)

References 37 publications

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“…The seminal work by Diaz-Sanchez et al 323 , demonstrated that exposure to diesel exhaust particles in the upper airways of healthy subjects was able to induce elevations in total IgE, elevations in allergen-specific IgE in allergic subjects, 324 and allergic sensitization to neo-antigen. 325 In cohort studies, genetic variants in TLR2, TLR4, 326 and glutathione S transferases [327][328][329] have been associated with increased asthma risk with air pollution exposure.…”

Section: Air Pollutionmentioning

confidence: 99%

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Hansbro

Kim

Starkey

et al. 2017

Immunological Reviews

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115

114

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Severe, steroid-resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with this disease experience more frequent exacerbations of asthma, are more likely to be hospitalized, and have a poorer quality of life. Effective therapies are urgently required, however, their development has been hampered by a lack of understanding of the pathological processes that underpin disease. A major obstacle to understanding the processes that drive severe, steroid-resistant asthma is that the several endotypes of the disease have been described that are characterized by different inflammatory and immunological phenotypes. This heterogeneity makes pinpointing processes that drive disease difficult in humans. Clinical studies strongly associate specific respiratory infections with severe, steroid-resistant asthma. In this review, we discuss key findings from our studies where we describe the development of representative experimental models to improve our understanding of the links between infection and severe, steroid-resistant forms of this disease. We also discuss their use in elucidating the mechanisms, and their potential for developing effective therapeutic strategies, for severe, steroid-resistant asthma. Finally, we highlight how the immune mechanisms and therapeutic targets we have identified may be applicable to obesity-or pollution-associated asthma.

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Section: Air Pollutionmentioning

confidence: 99%

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Hansbro

Kim

Starkey

et al. 2017

Immunological Reviews

Self Cite

115

114

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“…Furthermore, the aggravating effect of DEPs on allergic airway inflammation, that is IgE and histamine production, was enhanced when individuals had single nucleotide polymorphisms (SNPs) in the GSTM1 and GSTP1 gene . Moreover, a GSTM1 variant status led to decreased FEV 1 levels following DEPs and allergen co‐exposure . Finally, also genetic variants in the TLR2 and TLR4 genes influence the susceptibility to adverse effects of traffic‐related ambient PM on childhood asthma …”

Section: Air Pollution and Asthmamentioning

confidence: 99%

Insights in particulate matter‐induced allergic airway inflammation: Focus on the epithelium

Grove

Provoost

Brusselle

et al. 2018

Clin Experimental Allergy

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Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses. We describe the available literature on the topic including in vitro studies, findings in humans (ie observations in human cohorts, human controlled exposure and ex vivo studies) and in vivo animal studies. In brief, it has been shown that exposure to PM modulates the airway epithelium and promotes the production of several cytokines, including IL-1, IL-6, IL-8, IL-25, IL-33, TNF-α, TSLP and GM-CSF. Further, we propose that PM-induced type 2-promoting cytokines are important mediators in the acute and aggravating effects of PM on airway inflammation. Targeting these cytokines could therefore be a new approach in the treatment of asthma.

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“…Air pollutants allow for easier penetration of pollen and spore allergens because they trigger damage to the airway mucociliary clearance mechanisms [128,141]. Particulate matter smaller than 2.5 μm (PM 2.5 ) reaches deeply in the lungs and acts as an adjuvant that increases production of IgE [3,151,152]. Furthermore, exposure to diesel exhaust is known to impact DNA methylation and impaired regulatory T-cell functions, two mechanisms relevant for the immune response [104].…”

Section: Reviewmentioning

confidence: 99%

“…Furthermore, exposure to diesel exhaust is known to impact DNA methylation and impaired regulatory T-cell functions, two mechanisms relevant for the immune response [104]. Changes in FEV1 following allergen exposure have also been modified by controlled diesel exhaust exposure and GST genotype in a gene–environment interaction manner [152]. These GST variants are commonly present in the general population (i.e., from 23% to 62% depending on the ethnic group, in the USA) [153], so many people might experience amplified effects of air pollution–aeroallergen co-exposures in the outdoor environment.…”

Section: Reviewmentioning

confidence: 99%

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

Sierra-Heredia

North

Brook

et al. 2018

IJERPH

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Aeroallergens occur naturally in the environment and are widely dispersed across Canada, yet their public health implications are not well-understood. This review intends to provide a scientific and public health-oriented perspective on aeroallergens in Canada: their distribution, health impacts, and new developments including the effects of climate change and the potential role of aeroallergens in the development of allergies and asthma. The review also describes anthropogenic effects on plant distribution and diversity, and how aeroallergens interact with other environmental elements, such as air pollution and weather events. Increased understanding of the relationships between aeroallergens and health will enhance our ability to provide accurate information, improve preventive measures and provide timely treatments for affected populations.

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Effect of GST variants on lung function following diesel exhaust and allergen co-exposure in a controlled human crossover study

Cited by 23 publications

References 37 publications

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Insights in particulate matter‐induced allergic airway inflammation: Focus on the epithelium

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

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