Effect of Growth Hormone Treatment on Quality of Life of Short-Stature Children

Pilpel, Dina; Leiberman, Esther; Zadik, Zvi; Carel, Cynthia A.

doi:10.1159/000184581

Cited by 35 publications

(29 citation statements)

References 9 publications

(14 reference statements)

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“…Perhaps as a result of the varied definitions, it was not uncommon for some researchers to neglect to provide any definition of the construct measured by their instruments. [19][20][21][22][23][24] …”

Section: Definitions Of Qol and Hrqolmentioning

confidence: 99%

Paediatric quality of life instruments: a review of the impact of the conceptual framework on outcomes

Davis

Waters

Mackinnon

et al. 2006

Developmental Medicine &Amp; Child Neurology

227

208

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With an increasing number of paediatric quality of life (QOL) instruments being developed, it is becoming difficult for researchers and clinicians to select the most appropriate instrument. Reviews of QOL instruments tend to report only basic properties of the instruments such as domains and psychometric properties. This paper seeks to appraise critically the conceptual underpinnings of paediatric QOL instruments. A systematic review was conducted to identify QOL instruments for children aged 0 to 12 years, and to examine and compare their conceptual frameworks, definitions employed, and structure. Both generic and condition-specific measures were reviewed. Fourteen generic and 25 condition-specific QOL instruments were identified. Eleven types of definition of QOL and health-related QOL and three theories of QOL were identified. QOL was measured by a variety of domains including emotional, social and physical health, and well-being. Items commonly assessed difficulties, or intensity/frequency of feelings/symptoms, in contrast to positive aspects of life and happiness. The findings highlight the diversity that is apparent in the conceptualization of paediatric QOL and draw attention to the lack of empirical evidence for many of the fundamental assumptions. The impact of the conceptual underpinnings of the instruments on the resulting QOL scores is discussed.

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Section: Definitions Of Qol and Hrqolmentioning

confidence: 99%

Paediatric quality of life instruments: a review of the impact of the conceptual framework on outcomes

Davis

Waters

Mackinnon

et al. 2006

Developmental Medicine &Amp; Child Neurology

227

208

View full text Add to dashboard Cite

show abstract

“…Such assumptions would reinforce stereotypes that underlie discriminatory practices. For instance, while it is historically assumed that short stature (a clinical value) due to GH deficiency automatically impairs QoL, subjective analysis does not support this hypothesis (Pilpel et al 1995).…”

Section: Qol Measurementmentioning

confidence: 99%

“…Analysis of social parameters does not, however, reveal any impairment in physical abilities, self-esteem, school achievements, leisure activities, well-being, and relationships in short children (Erling et al 1995, Pilpel et al 1995 nor any reduction in marriage or employment status in short adults (Rikken et al 1995). Similarly, Busschbach et al (1998) failed to observe a direct relationship between QoL and short stature resulting from Turner syndrome, chronic renal failure, GHD, or idiopathic short stature, when QoL was measured by the time trade-off method and the NHP.…”

Section: Short Stature and Qolmentioning

confidence: 99%

“…Although generic measures have been developed to quantify QoL in children (Eiser & Morse 2001), they have not been widely applied to GHD children. Questionnaires based solely on self-report , Pilpel et al 1995 or on parental report (Haverkamp & Noeker 1998) have been developed, but have not been well-validated nor extensively used. The development of a GHD-specific module of the Pediatric Quality of Life instrument might be appropriate, since this questionnaire has been validated and works well for other chronic childhood conditions such as asthma or diabetes (Varni et al 2001).…”

Section: Gh Deficiencymentioning

confidence: 99%

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Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

Hull

Harvey²

2003

Journal of Endocrinology

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The actions of growth hormone (GH) are not restricted to growth: GH modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary physiology. The importance of GH in most physiological systems suggests that GH deficiency at any age would be associated with significant morbidity. However, prior to the advent of recombinant GH, cadaverderived GH was only used therapeutically to correct the height deficit, and thereby hypothetically improve quality of life (QoL), in GH-deficient children. Physicians now have access to unlimited, albeit expensive, supplies of recombinant GH, and are considering the advisability of GH replacement or supplementation in other patient populations. This paper analyses studies investigating the relationship between GH and QoL in GH-deficient children or adults, in GH-replete short children suffering from idiopathic short stature, Turner syndrome, or intrauterine growth retardation and in GH-deficient or replete elderly adults. Possible mechanisms by which GH might improve QoL at neural and somatic sites are also proposed.

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“…Studies comparing GHD children with matched control groups of untreated or short, healthy children have shown no group differences on proxy-indicators of child QOL (e.g. educational achievements, school attendance), parent reports of child QOL or general psychological adjustment [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

The Effects of Growth Hormone Treatment on Health-Related Quality of Life in Children

Sheppard

Eiser²,

Davies³

et al. 2006

Horm Res Paediatr

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Background/Aims: The effects of growth hormone deficiency (GHD) on linear growth in children are well documented, but there is less convincing evidence regarding the impact on health-related quality of life (QOL). We examined QOL in children aged 8–16 years with acquired GHD following treatment for malignancy (AGHD) or idiopathic GHD (IGHD) on commencing growth hormone treatment (GHT) over 6 months. We adopted a longitudinal design involving consecutive patients and their families attending clinic over an 18-month period. Mothers and children were invited to complete questionnaires before GHT (T1) and 6 months later (T2). Methods: Mothers of 22 children (AGHD n = 14; IGHD n = 8) completed standardized measures of child QOL and behaviour. Children completed parallel measures of QOL, short-term memory tasks and fitness either in clinic or at the family home. Results: For children with AGHD, QOL was significantly below population norms at T1 and improved over time. For children diagnosed with IGHD, QOL at T1 was below, but comparable with population norms. QOL improved over time, though not significantly. Conclusion: GHT is potentially valuable for improving QOL in children, especially in cases of AGHD. We conclude that benefits of GHT for QOL need to be evaluated independent of different diagnostic groups.

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Effect of Growth Hormone Treatment on Quality of Life of Short-Stature Children

Cited by 35 publications

References 9 publications

Paediatric quality of life instruments: a review of the impact of the conceptual framework on outcomes

Paediatric quality of life instruments: a review of the impact of the conceptual framework on outcomes

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

The Effects of Growth Hormone Treatment on Health-Related Quality of Life in Children

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