Effect of growth hormone therapy on feeding problems and food intake in children with growth disorders

Blissett, Jacqueline; Harris, G. W.; Kirk, J A

doi:10.1080/080352500750043927

Cited by 23 publications

(20 citation statements)

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“…A chronic increase in energy intake has been reported in children with accelerated growth following GH treatment (12), however this is thought to be secondary to increased metabolic demands (13) and acute changes in food intake have not been reported (14). In the non GH-deficient state there is no consistent evidence for increased energy intake in response to GH (15)(16)(17).…”

Section: Methodsmentioning

confidence: 54%

Ghrelin Enhances Appetite and Increases Food Intake in Humans

Wren¹,

Seal²,

Cohen³

et al. 2001

The Journal of Clinical Endocrinology &Amp; Metabolism

1,794

748

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Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased food intake, weight gain and adiposity in rodents. The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects of intravenous ghrelin (5.0 pmol/kg/min) or saline infusion on appetite and food intake in a randomised double-blind cross-over study in nine healthy volunteers. There was a clear-cut increase in energy consumed by every individual from a free-choice buffet (mean increase 28 ± 3.9%, p<0.001) during ghrelin compared with saline infusion. Visual analogue scores for appetite were greater during ghrelin compared to saline infusion. Ghrelin had no effect on gastric emptying as assessed by the paracetamol absorption test. Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight. _____________________________________________________________________________________________________

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Section: Methodsmentioning

confidence: 54%

Ghrelin Enhances Appetite and Increases Food Intake in Humans

Wren¹,

Seal²,

Cohen³

et al. 2001

The Journal of Clinical Endocrinology &Amp; Metabolism

1,794

748

View full text Add to dashboard Cite

show abstract

“…Before discharge, it is advisable to achieve an absence of ketonuria following at least 12 h of feeding, without intravenous support. When hypoglycaemia remains a problem, early GH therapy should be considered 91,92 (see following section on GH therapy). …”

Section: Prevention Of Hypoglycaemiamentioning

confidence: 99%

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

et al. 2016

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“…However, GH-deficient patients seem to increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect (11,12). GH has also been shown to increase food intake in experimental animals in some (5) but not all studies (13)(14)(15)(16).…”

mentioning

confidence: 99%

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

et al. 2005

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It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect. Diabetes 54:51-62, 2005

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Effect of growth hormone therapy on feeding problems and food intake in children with growth disorders

Abstract: GH has a significant impact on both the food intake and parent-child interaction at mealtimes of children with SRS and TS.

Cited by 23 publications

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Ghrelin Enhances Appetite and Increases Food Intake in Humans

Ghrelin Enhances Appetite and Increases Food Intake in Humans

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

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