Effect of Growth Hormone-Releasing Factor on Plasma Growth Hormone, Prolactin and Somatomedin C in Hypopituitary and Short Normal Children

Abstract

We studied the effect of a single intravenous bolus of 0.5 µg/kg of growth hormone-releasing factor (GRF) on plasma GH, prolactin (PRL) and somatomedin C (SMC) in 12 short normal children and 24 patients with severe GH deficiency (GHD), i.e. GH < 5 ng/ml after insulin and glucagon tolerance tests. GRF elicited an increase in plasma GH in both short normal and GHD children. The mean GH peak was lower in the GHD than in the short normal children (8.2 ± 2.5 vs. 39.2 ± 5.1 ng/ml, p < 0.001). In the GHD patients (but not in the short normals) there was a negative correlation between bone age and peak GH after GRF (r = -0.58, p < 0.005); GH peaks within the normal range were seen in 5 out of 8 GHD children with a bone age < 5 years. In the short normal children, GRF had no effect on plasma PRL, which decreased continuously between 8.30 and 11 a.m. (from 206 ± 22 to 86 ± 10 µU/ml, p < 0.005), a reflection of its circadian rhythm. In the majority of the GHD patients, PRL levels were higher than in the short normal children but had the same circadian rhythm, except that a slight increase in PRL was observed 15 min after GRF; this increase in PRL was seen both in children with isolated GHD and in those with multiple hormone deficiencies; it did occur in some GHD patients who had no GH response to GRF. Serum SMC did not change 24 h after GRF in the short normal children. We conclude that: (1) in short normal children: (a) the mean GH response to a single intravenous bolus of 0.5 µg/kg of GRF is similar to that reported in young adults and (b) GRF has no effect on PRL secretion; (2) in GHD patients: (a) normal GH responses to GRF are seen in patients with a bone age < 5 years and

Growth Hormone Release in Children after Cranial Irradiation

“…In this study we found no temporary increase in prolactin after GHRH injection (2 pg/kg). This con trasts with the findings of other investiga tors, who have found a dose-dependent in crease in prolactin levels after GHRH [18,19]. No other hypophyseal hormone was found to be affected by GHRH in this study.…”

Increase in Renal Plasma Flow and Glomerular Filtration Rate during Growth Hormone Treatment May Be Mediated by Insulin-Like Growth Factor I

“…GH is the strongest secretagogue for IGF I, which is synthesized in several organs including the kid neys and liver [10], GH-deficient subjects are also defi cient in IGF I and II. The plasma IGF I levels in these individuals are often below the detection limit of com mercially available radioimmunoassays [11]. Plasma IGF levels start to rise about 8-16 h after a single GH injection.…”

Factors Influencing the Growth Hormone Response to Growth Hormone-Releasing Hormone in Children with Idiopathic Growth Hormone Deficiency

“…The negative correlations between the GH peak after GHRH and the chronological [15]or bone ages [16]in children with GH deficiency have been previously reported, but not in normal children. We found a higher GH response in patients aged less than 5 years than in the oldest, as recently reported [2].…”