Effect of Growth Hormone Administration on the Mass and Strength of Muscles in Healthy Young Adults: A Systematic Review and Meta-Analysis

Sergeeva, K. V.; Miroshnikov, A.B.; Smolensky, A. V.

doi:10.1134/s0362119719030162

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…As MSTN is the most common type of skeletal muscle, it is of interest in studies related to sports science [14]. However, its expression is also noted in the heart and adipose tissues [15,16].…”

Section: History Of Discoverymentioning

confidence: 99%

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: a Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

Aksenov

Kruszewski

2022

Preprint

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Introduction. Variant (rs1805086, c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether the K and R allelic variants of MSTN rs1805086 are valid genetic factors that can affect the strength phenotype of athletes’ skeletal muscles. Purpose. To conduct a systematic review and meta-analysis of the association of MSTN rs1805086 polymorphism with the strength phenotype of athletes. Materials and methods. This study analyzed 71 research articles on myostatin and performed a meta-analysis of MSTN K153R rs1805086 polymorphism in strength-oriented athletes and control (non-athletes) group. Results. It was found that athletes in the strength-oriented athletes group had a higher frequency of the R minor allele than that in the control group (OR = 2.02, P = 0.05). Conclusion. Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.

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Section: History Of Discoverymentioning

confidence: 99%

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: a Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

Aksenov

Kruszewski

2022

Preprint

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“…For therapeutic use, several GHRH analogs have been developed from the bioactive part of GHRH (1-29 GHRH) with amino-acid modifications or the addition of chemical groups, allowing peptide stabilization and a longer halflife time [1,2]. Due to their biological activity, some of them could also be misused by athletes to improve their performances [3,4]. Indeed, GH and its releasing factors can induce ergogenic activity and accelerate injury recovery [5].…”

Section: Introductionmentioning

confidence: 99%

Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis

et al. 2023

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A capillary electrophoresis method is proposed to analyze the four most wellknown growth hormone-releasing hormone (GHRH) analogs that are misused by athletes. Dimethyl-β-cyclodextrin used as a chiral selector allowed, for the first time, the separation of those basic peptide analogs, including enantiopeptides (sermorelin and CJC-1293) that differ by the chirality of only one amino acid. To increase the method sensitivity, electrokinetic preconcentration methods have been investigated. The large volume sample stacking with polarity switching (PS-LVSS) method with an injected sample volume corresponding to 80% of the capillary one was found superior to the sweeping in terms of signal enhancement factor (SEF). Acid and organic solvent addition to the sample (0.1 mM phosphoric acid with 30% methanol) led to a twofold signal improvement, when compared to water as a matrix. We increased capillary dimensions to provide a signal enhancement through the injection of a larger sample volume. Finally, using a combination of the optimized PS-LVSS preconcentration with the chiral capillary zone electrophoresis (CZE), the GHRH analogs were separated and limits of detection between 75 and 200 ng/mL were reached. This method was successfully applied to urine after a desalting step. An optimized C18 SPE was used for that purpose in order to provide low sample conductivity (<130 µS/cm) and preserve the efficiency of LVSS preconcentration. SEF of 640 was obtained with desalted urine spiked with sermorelin by comparison to the CZE (without preconcentration) method.

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“…As MSTN is the most common type of skeletal muscle protein, it is of interest in studies related to sports science [ 14 ]. However, its expression is also noted in the heart and adipose tissues [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

Kruszewski

Aksenov

2022

Genes

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Polymorphism (rs1805086), c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether MSTN rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes’ skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of MSTN rs1805086 polymorphism with the strength phenotype of athletes. This study analyzed 71 research articles on MSTN and performed a meta-analysis of MSTN K153R rs1805086 polymorphism in strength-oriented athletes and a control (non-athletes) group. It was found that athletes in the strength-oriented athlete group had a higher frequency of the R minor variant than that in the control group (OR = 2.02, P = 0.05). Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.

show abstract

Effect of Growth Hormone Administration on the Mass and Strength of Muscles in Healthy Young Adults: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 33 publications

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: a Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: a Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation

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