Effect of growth hormone administration to hypophysectomized rats on muscle lipid metabolism

Davidson, Mayer B.

doi:10.1016/0026-0495(79)90177-x

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…In line with these results, there was no effect of insulin treatment on heart LPL activity, but a marked effect on adipose tissue LPL activity. GH treatment has been shown to decrease basal and insulin-stimulated glucose uptake in muscles of the rat (Goodman & Schwartz 1974, Davidson 1979, indicating decreased insulin responsiveness. Serum insulin levels were increased by GH treatment without any effect on glucose concentrations, indicating that decreased insulin responsiveness was balanced by an increased insulin secretion.…”

Section: Figurementioning

confidence: 99%

GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats

Oscarsson

Ottosson²,

Vikman-Adolfsson³

et al. 1999

Journal of Endocrinology

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Changes in GH secretion are associated with changes in serum lipoproteins, utilisation of fuels and body composition. Since lipoprotein lipase (LPL) is a key enzyme in the regulation of lipid and lipoprotein metabolism, changes in LPL activity may contribute to these effects of GH. The present study was undertaken to investigate the role of GH and the GH-dependent growth factor, IGF-I, in the regulation of LPL in heart, skeletal muscle and adipose tissue. Female rats were hypophysectomised at 50 days of age. One week later, hormonal therapy was commenced. All hypophysectomised rats received -thyroxine and cortisol. Adipose tissue, the heart, soleus and gastrocnemius muscles were excised after 1 week of hormonal therapy. The effect of insulin injections on adipose tissue and heart LPL activity was also studied. In separate experiments, LPL activity in post-heparin plasma was measured. Hypophysectomy had no effect on adipose tissue LPL activity, whereas activity was reduced in heart, soleus and gastrocnemius muscle tissues. GH treatment had no significant effect on LPL activity in adipose tissue or soleus muscle, but increased the LPL activity in heart and gastrocnemius muscle. GH treatment increased post-heparin plasma LPL activity. Recombinant human IGF-I treatment (1·25 mg/kg per day) markedly reduced LPL activity in adipose tissue, but had no effect in muscle tissues. The effect of IGF-I treatment on adipose tissue LPL was not reflected by a decrease in post-heparin plasma LPL activity. Daily injections of insulin for 7 days increased LPL activity in adipose tissue but had no effect on heart LPL activity. In adipose tissue, LPL mRNA levels tended to decrease as a result of IGF-I treatment. In the muscle tissues, no significant effects of hypophysectomy, GH or IGF-I treatment on LPL mRNA levels were observed.It is concluded that GH increases heart and skeletal muscle tissue LPL activity, which probably contributes to an increased post-heparin plasma LPL activity. The effect of GH on muscle LPL activity is probably not mediated by IGF-I or insulin. Insulin and IGF-I have opposite effects on LPL activity in adipose tissue.

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Section: Figurementioning

confidence: 99%

GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats

Oscarsson

Ottosson²,

Vikman-Adolfsson³

et al. 1999

Journal of Endocrinology

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“…Our results suggest that neither insulin, which fell to the lowest ranges from the first hours of fasting, nor the cortisol response, which was appropriate to low blood glucose concentrations, is involved. Moreover, previous studies have demonstrated that hypoglycaemia is neither more frequent nor more severe whether ACTH-deficiency is associated or not (2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…It is now well established that children with growth hormone (GH) deficiency show an increased risk of developing hypoglycaemia when fasting. Symptomatic or asymptomatic hypoglycaemia have been described in 15-30% of young children with GH-deficiency, be it isolated or associated with other pituitary hormone deficiencies (1,2). In some cases, especially in the newborns and infants, hypoglycaemia is the first sign of GH-deficiency.…”

mentioning

confidence: 99%

Exploration of glucose homeostasis during fasting in growth hormone‐deficient children

et al. 1998

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In order to define more precisely the risk of hypoglycaemia in GH-deficient children and to clarify the role of growth hormone (GH) in glucose homeostasis, a 24-h fast was monitored in 10 GH-deficient children aged 1.1-6.5 y. Asymptomatic hypoglycaemia (blood glucose Յ2.6 mmol/l) occurred in 9/10 children, 2 of whom prematurely interrupted the test. Blood glucose profile was not reproducible between children and had no correlation with age ( p ¼ 0:48). Gluconeogenesis was considered as non-altered as read from the normal plasma lactate and pyruvate concentrations throughout the test. Plasma ketone body concentrations increased during the test, but were lower than expected with respect to the decrease of blood glucose. This suggests insufficient ketogenesis which could exacerbate hypoglycaemia in GH-deficient children if brain glucose utilization were not alleviated by ketone body oxidization, as is normally the case. The positive glucose response after glucagon stimulation in 6/10 patients indicated normal hepatic glycogen content. However, these responses were unexpected following the prolonged fast and its concomitant hypoglycaemia, and would therefore tend to suggest a defect in glycogenolysis. These results confirm the tendency to hypoglycaemia, even after infancy, in GH-deficient children. These hypoglycaemias may occur by different types of malfunctioning, such as insufficient ketogenesis or a defect in glycogenolysis. These hypotheses require confirmation by a more systematic study of the metabolic and hormonal changes that occur during fasting in both GH-deficient and normal children. ٖ Fasting, glucagon, hypoglycaemia, ketogenesis D Jaquet, Paediatric Endocrinology and Diabetology Units, Hôpital Robert Debré, 48 Boulevard Serurier,

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“…GH treatment of hypophysectomized rats for 10 days elevated blood glu cose and reduced glucose uptake by diaphragm muscle (Davidson, 1979).…”

Section: Growth Hormonementioning

confidence: 92%

Plasma hormone concentrations and profiles in growing steers with different growth potentials

Grigsby

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Effect of growth hormone administration to hypophysectomized rats on muscle lipid metabolism

Cited by 10 publications

References 36 publications

GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats

GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats

Exploration of glucose homeostasis during fasting in growth hormone‐deficient children

Plasma hormone concentrations and profiles in growing steers with different growth potentials

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