Effect of Green Tea Supplementation on Blood Cadmium and Male Sex Hormone Levels in Automobile Workers in Emene, Enugu State, Nigeria

Nwando, Obi-Ezeani; Emmanuel, Dioka Chudi; Chukwuemeka, Meludu Samuel; Joy, Onuorah; Opeyemi, Usman Saheed

doi:10.9734/jammr/2018/42879

Cited by 2 publications

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References 17 publications

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“…Green tea (Camellia sinensis), a member of the Theaceae family, seems to be a good choice for overcoming CdCl2-induced infertility; green tea flavonoid epigallocatechin-3-gallate (EGCG) is a classified as a potent antioxidant and thus it could prevent OS through combating ROS over production [8]. Lately in Nigeria, it has Mans Vet Med J 21:1 (2020) [31][32][33][34][35] been recorded that green tea supplementation reduced the cadmium level and regulated the levels of sex hormones in automobile workers [9]. Here, we aimed to investigate the effect of green tea extract on the testicular damage induced by CdCl2 in male rats.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

Barghout¹,

El-Sayed²,

El-Said³

2020

Mansoura Veterinary Medical Journal

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Investigating the effect of green tea extract (GTE) on the testicular damage induce d by cadmium chloride CdCl2 in male rats. Design: Random iz e d controlle d study. Animals : 40 male Wistar rats. Procedures: Rats were randomly divided into four groups: A) control group (each rat daily received pellet diet); B) GTE group each rat daily received pellet diet as well as 3 ml of 1.5 % w/v GTE, C) CdCl2 group each rat was I/P injected a single dose of 1 mg/kg CdCl2, then daily received pellet diet, and D) CdCl2+GTE group each rat was I/P injected a single dose of 1 mg/kg CdCl2 then daily received pellet diet as well as 3 ml of 1.5 % w/v GTE. After 30 days, blood samples were collected for hormonal assays (testosterone, FSH, and LH). In addition, both testes were collected; one of them was used for quantification of 17-beta hydroxysteroid dehydrogenase III (17β-HSDIII) gene expression using a real-time PCR. The other testis was used for determination of catalase and reduced glutathione; GSH, Nitric oxide (NO) and malondia lde hyde (MDA) levels. Results: CdCl2 decreased serum testosterone levels and its synthesis pathway (17β-HSDIII testicular gene expression). While antioxidants catalase and GSH were reduced, oxidants MDA were enriched in the testes of CdCl2-poisoned rats.This CdCl2-promoted testicular dysfunction was corre cte d via the adminis tra tion of GTE to male rats. Conclusion and clinical relevance: GTE could be used as a remedy for protecting against CdCl2-induce d testicula r damage in male rats.

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Section: Introductionmentioning

confidence: 99%

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

Barghout¹,

El-Sayed²,

El-Said³

2020

Mansoura Veterinary Medical Journal

View full text Add to dashboard Cite

show abstract

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

El-Desoky¹,

El-Sayed²,

El-Said³

2020

Mans Vet Med J

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Objective: Investigating the effect of green tea extract (GTE) on the testicular damage induced by cadmium chloride CdCl2 in male rats. Design: Randomized controlled study. Animals: 40 male Wistar rats. Procedures: Rats were randomly divided into four groups: A) control group (each rat daily received pellet diet); B) GTE group each rat daily received pellet diet as well as 3 ml of 1.5 % w/v GTE, C) CdCl2 group each rat was I/P injected a single dose of 1 mg/kg CdCl2, then daily received pellet diet, and D) CdCl2+GTE group each rat was I/P injected a single dose of 1 mg/kg CdCl2 then daily received pellet diet as well as 3 ml of 1.5 % w/v GTE. After 30 days, blood samples were collected for hormonal assays (testosterone, FSH, and LH). In addition, both testes were collected; one of them was used for quantification of 17-beta hydroxysteroid dehydrogenase III (17β-HSDIII) gene expression using a real-time PCR. The other testis was used for determination of catalase and reduced glutathione; GSH, Nitric oxide (NO) and malondialdehyde (MDA) levels. Results: CdCl2 decreased serum testosterone levels and its synthesis pathway (17β-HSDIII testicular gene expression). While antioxidants catalase and GSH were reduced, oxidants MDA were enriched in the testes of CdCl2-poisoned rats. This CdCl2-promoted testicular dysfunction was corrected via the administration of GTE to male rats. Conclusion and clinical relevance: GTE could be used as a remedy for protecting against CdCl2-induced testicular damage in male rats.

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Effect of Green Tea Supplementation on Blood Cadmium and Male Sex Hormone Levels in Automobile Workers in Emene, Enugu State, Nigeria

Cited by 2 publications

References 17 publications

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

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