Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

Quezada-Fernández, Patricia; Trujillo-Quirós, Jhonatan; Pascoe-González, Sara; Rangel, Walter Trujillo; Cardona-Müller, David; Ramos-Becerra, Carlos; Barocio-Pantoja, Maricruz; Cerda, Mariana Rodríguez-De la; Sánchez-Rodríguez, Esther Nérida; Cardona-Muñóz, Ernesto Germán; García-Benavides, Leonel; Grover-Páez, Fernando

doi:10.1080/09637486.2019.1589430

Cited by 30 publications

(25 citation statements)

References 34 publications

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“…Similarly, a positive association between the dietary intake of meat and meat products and skin AGEs accumulation was found [ 59 ]. Lastly, multiple clinical trials using polyphenols showed reduced AGEs-induced inflammation in tissues, including bone, particularly in subjects with T2DM [ 60 , 61 ]. In conclusion, one of the underlying mechanisms of Mediterranean diet in improving bone health could be related to reduced AGEs intake and the inhibition of AGEs by antioxidants and polyphenols.…”

Section: Discussionmentioning

confidence: 99%

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

et al. 2020

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Animal studies suggest a role for dietary advanced glycation end-products (dAGEs) in bone health, but human studies on dAGEs in relation to bone are lacking. We aimed to study whether dAGEs intake is associated with the parameters of bone strength namely, bone mineral density (BMD), prevalent vertebral (VFs), and major osteoporotic fractures (MOFs = hip, wrist, proximal humerus, and clinical VFs). 3949 participants (mean age 66.7 ± 10.5 years) were included from a Rotterdam study for whom Carboxymethyllysine (CML—a dietary AGE) was estimated from food frequency questionnaires combined with dAGEs databases. Multivariable linear and logistic regression models were performed adjusting for age, sex, energy intake, dietary quality, physical activity, diabetes, smoking, renal function, and cohort effect and for models on fractures, subsequently for BMD. We observed no association of CML with BMD at both femoral neck (β = −0.006; p = 0.70) and lumbar spine (β = −0.013; p = 0.38). A higher intake of CML was linearly associated with VFs (Odds ratio, OR = 1.16, 95% CI (1.02–1.32) and a similar but non-significant trend with MOFs (OR = 1.12 (0.98–1.27). Additional adjustment for BMD did not change the associations. Our results imply a positive association between dietary intake of CML and VFs independent of BMD. Future studies are needed in order to elucidate whether associations found are causal.

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Section: Discussionmentioning

confidence: 99%

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

et al. 2020

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“…Four articles were excluded, because they did not have the desired data. Finally, 11 trials [14-24] were included for the present meta-analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the 11 trials [14-24] are presented in Table 1. The eligible studies were published between 2005 and 2019 and were done in Japan [14, 15, 17], Iran [16, 18, 20, 23], Taiwan [19, 21], Brazil [22], and Mexico [24]. The sample size in these trials ranged between 20 [24] and 120 patients [15].…”

Section: Resultsmentioning

confidence: 99%

Effect of Green Tea on Anthropometric Indices and Body Composition in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2020

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Aim: Previous studies that investigated the effect of green tea/green tea extract on anthropometric indices among type 2 diabetes mellitus (T2DM) patients found inconsistent results. Thus, in order to clarify the efficacy of green tea supplementation on anthropometric indices and body composition, we conducted a systematic review and meta-analysis to sum up the evidence of randomized controlled trials. Methods: A systematic search was conducted in the Scopus, ISI Web of Science and PubMed to find the related articles, up to June 2019. Meta-analysis was performed using the random effects model, and the I2 index was used to evaluate the heterogeneity. Results: Eleven articles were eligible. Our meta-analysis indicated that green tea consumption significantly decreased body weight, body mass index (BMI), and body fat (BF). The beneficial effect of green tea intake was observed in long-term intervention (>8 weeks), at lower doses of green tea (dosage ≤800 mg/day), and in overweight patients. Conclusion: This study revealed the beneficial effects of green tea consumption in reducing body weight, BMI, and BF in T2DM patients. It should be noted that green tea was effective in long-term intervention, at lower doses of green tea, and in overweight patients.

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“…It is a powerful antioxidant capable of neutralizing reactive oxygen species and free radicals involved in aging and chronic degenerative diseases. Indeed, EGCG is characterized by antitumor properties [18], antidiabetic agents [5], anti-inflammatory, and especially by antioxidant properties [19]. During this work, we tested in vivo the antioxidant and antidiabetic properties of EGCG and we made an attempt to study the in vitro activity of EGCG given that polyphenols can stabilize excess free radicals, preventing the establishment of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The (-)-epigallocatechin gallate (EGCG) ameliorates hyperglycemia and hyperlipidemia - mediated oxidative stress in liver and kidney of alloxan induced diabetic mice

Soussi¹,

Aouedi²,

Akrouti³

et al. 2020

Preprint

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Background: Diabetes mellitus has become a serious problem associated with health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have led to a determined search for alternative natural therapeutic agents. The present study is conducted to evaluate the hypoglycemic, antilipidemic and antioxidant effects of EGCG in surviving diabetic mice.Methods: Alloxan diabetic mice were injected with EGCG. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglycerides, urea, creatinine and transaminases. Their livers and kidneys were isolated to perform histological analysis.Results: Both EGCG and insulin treatments of diabetic mice resulted in a significant reduction in fasting blood glucose level. EGCG supplementation also ameliorated hepatic as well as renal toxicity indices. Moreover, diabetic mice injected by EGCG exhibited significant changes in antioxidant enzyme activities in the liver and kidney. Histological analyses also showed that it exerted an ameliorative action on these organs and efficiently protected the liver-kidney functions of diabetic mice.Conclusion: The findings revealed that EGCG administration induced attractive curative effects on diabetic mice, particularly in terms of liver-kidney functions. EGCG can, therefore, be considered as a potential strong candidate for future application to treat and prevent diabetes.

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Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

Cited by 30 publications

References 34 publications

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

Effect of Green Tea on Anthropometric Indices and Body Composition in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

The (-)-epigallocatechin gallate (EGCG) ameliorates hyperglycemia and hyperlipidemia - mediated oxidative stress in liver and kidney of alloxan induced diabetic mice

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