Effect of grapefruit juice on amiodarone induced nephrotoxicity in albino rats

Abstract

Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias. The present work studied the effect of amiodarone on the kidney of albino rats and the possible ameliorative role of grapefruit juice. Administration of amiodarone by gastric intubation (18 mg/kg body weight (b.w.), daily for 5 weeks) caused many histological alterations including intertubular leucocytic infiltrations, degeneration of the renal tubules, and atrophy of the glomeruli. Amiodarone caused marked elevation in serum creatinine and blood urea nitrogen. Histochemical examination of the renal tubules revealed depletion of glycogen and total proteins. Besides, animals administered with amiodarone showed an increase of apoptotic bands as detected by gel electrophoresis. Treating animals with amiodarone and grapefruit juice (27 ml/kg b.w.) caused an improvement in histological and histochemical appearance of the kidney together with decrease of serum creatinine and blood urea nitrogen. Moreover, the apoptosis was decreased. It is concluded from the obtained results that grapefruit juice ameliorates the nephrotoxicity of amiodarone in albino rats and this may be due to the potent antioxidant effects of its components.

Alteration in thiols homeostasis, protein and lipid peroxidation in renal tissue following subacute oral exposure of imidacloprid and arsenic in Wistar rats

“…In the present study, IMI caused a significant decline in the activities of SOD (36.0%), GST (53.7%), GR (30.1%), GPx (50.2%) and CAT (36.0%) after repeated oral administrations in rats for 28 days ( Table 2 ). Similar results have also been observed following subacute exposure of deltamethrin [ 42 ], cypermethrin [ 51 ] and acetamiprid [ 52 ].…”

Ameliorative effect of vitamin C on cypermethrin-induced hepatotoxicity and renal malfunction of adult male rats.

“…Urea and creatinine concentration was significantly increased in cypermethrin -treated group compared to the control one. Such findings are in agreement with that reported in other studies (Yousef et al 2003;Saxena and Saxena, 2010y;Sankar et al, 2012 ;Sakr and Albarakai, 2014).…”

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

“…An increase in hepatic carbohydrates, proteins and DNA was observed in rats given and AlCl 3 plus grapefruit. These results are in line with the report of [36] and [37] who reported that grapefruit juice restores the renal contents of carbohydrates and proteins to normal contents. [13] reported that rats were given grapefruit juice prior to treatment with aflatoxin-B 1 resulted in a noticeable reduction of DNA damage in the liver.…”