Effect of granulocyte‐macrophage colony‐stimulating factor on neutrophil function in idiopathic bronchiectasis

Abstract

PBN function was preserved in idiopathic bronchiectasis. Enhancement of neutrophil phagocytosis and superoxide generation by GM-CSF requires further study.

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

“…Furthermore, patients with a low capacity for neutrophil-generated oxidative burst also demonstrated a reduced capacity for intracellular bactericidal activity by the neutrophils. These data, however, were not reflected in two small studies of adult bronchiectasis where no impairment in oxidative burst by circulating neutrophils was found (29,32), although impairment of airway neutrophils was observed (29). The discrepancies between these data may be attributed to the methods used to induce oxidative burst (bacterial phagocytosis versus synthetic peptide) or the clinical characteristics of the study cohorts (age and severity of disease).…”

Management of bronchiectasis in adults

“…Airway bacterial colonisation occurs because of impaired mucociliary clearance and because of failure of neutrophil opsonophagocytic killing. Since neutrophils from bronchiectasis patients are believed to be normal prior to their arrival in the airway, it is likely that the airway inflammatory milieu itself impairs bacterial clearance [15,16]. Work over several decades has implicate neutrophil elastase in this process.…”

Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology

“…Bronchiectasis is characterized as vicious cycle of chronic purulent airway inflammation with bronchodilation. Neutrophils play an important role in airway inflammation, and so the activity of neutrophils has been studied in idiopathic bronchiectasis and control patients . The result showed similar response of neutrophils to granulocyte macrophage–colony stimulating factor in these two groups, suggesting neutrophil phagocytosis and generation of oxidative species have been preserved in bronchiectasis patients, although the exhaled condensation may not detect the difference .…”

“…Neutrophils play an important role in airway inflammation, and so the activity of neutrophils has been studied in idiopathic bronchiectasis and control patients . The result showed similar response of neutrophils to granulocyte macrophage–colony stimulating factor in these two groups, suggesting neutrophil phagocytosis and generation of oxidative species have been preserved in bronchiectasis patients, although the exhaled condensation may not detect the difference . Macrolide antibiotics including azithromycin has been shown to be beneficial in reducing symptoms and exacerbations, with an underlying mechanism thought to be biofilm disruption (which helps antibiotics penetration) and suppressive activity on airway inflammation.…”

“…A number of validated instruments are available to assess health status and to predict mortality and guide health care in patients with respiratory disease . Two recent additions to this group of measurement tools are the COPD assessment test that measures health status and the Simplified Acute Physiology Score 3, which was developed to predict mortality in critically ill patients . In two original studies in Respirology this year, Kon and colleagues reported that the COPD assessment test is responsive to pulmonary rehabilitation in respiratory disease patients without COPD and correlates with the different domains of the validated chronic respiratory disease questionnaire, supporting that it is a practical alternative to more traditional measures.…”