Effect of gonadotrophins and of testosterone on organ weights and zinc-65 uptake in the male rat

Rosoff, Betty; Martin, Constance R.

doi:10.1016/0016-6480(68)90011-7

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…This is corroborated by the observation, at the light and electron microscopic level, of degenerating cells in the lumen of acini only in animals treated with LH and FSH. Our data are in keeping with a report of decreased uptake of 65Zn by lateral prostatic tissue of FSH-treated intact animals [36]. Rosoff and Martin [36] have suggested that FSH may have an indirect effect on lateral prostatic tissue by increasing production of estrogen.…”

Section: Discussionsupporting

confidence: 93%

Hormonal effects on zinc concentration and morphology of rat lateral prostate gland

1984

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Hypophysectomized rats were injected with prolactin and/or testosterone, and luteinizing hormone (LH) and prolactin and/or follicle-stimulating hormone (FSH). Tissue from the lateral prostate was processed for spectrophotometric determination of zinc and for electron microscopy. Changes in zinc concentration, epithelial height, and morphological characteristics were used to assess the effect of hormonal replacement on functional activity. Although testosterone administration resulted in full restoration of all parameters, there was no evidence of a synergistic effect of prolactin and testosterone. Prolactin alone decreased the zinc concentration and increased the epithelial height compared with control animals, and there was evidence of epithelial hyperplasia. Luteinizing hormone, alone or combined with prolactin or prolactin and FSH, resulted in a marked increase of epithelial height and restoration of morphological features found in intact animals; however, only a slight increase of zinc concentration over control values was elicited. Combined LH and FSH administration reduced epithelial height and zinc concentration compared with the other LH regimes, and there was evidence of cellular degeneration.

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Section: Discussionsupporting

confidence: 93%

Hormonal effects on zinc concentration and morphology of rat lateral prostate gland

1984

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“…In contrast, no stimulation of growth was observed in the dorsolateral prostates even 12 months after the pituitary grafting. From these observations, it may be possible that the ventral and dorsolateral pros tates of mice respond in a different manner to prolactin as reported in rats by Holland and Lee [1980], The dif ferent response of the ventral and the dorsal prostates of rats to sex hormones [Tisell, 1971] and HCG [Rosoff and Martin, 1968] has also been reported.…”

Section: Discussionmentioning

confidence: 73%

Effects of Pituitary Grafting and CB-154 Treatment on the Growth of Prostates in Mice

Mori¹,

Nagasawa²

1984

Cells Tissues Organs

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Implantation of a single anterior pituitary into the ventral prostates of intact mice induced a significant increase in the weight and the area occupied by the glands of ventral prostates associated with the elevation of circulating prolactin. However, the growth of the dorsolateral prostates was not augmented by the treatment. Injection of CB-154 (bromocriptine-mesilate) during the developmental stage of the prostatic tissue (3–5 weeks of age) suppressed the weight increase of ventral prostates but not dorsolateral prostates in intact mice. All results suggest the different response of the ventral and the dorsolateral prostates to prolactin. Pituitary grafting produced hyperplastic lesions in the prostates, however, modified little the effects of carcinogen on the tissue.

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“…When it is administered with luteinizing hormone in the former and with testosterone in the later, it synergizes with these hormones (Gunn et al, 1965). Rosoff and Martin (1968) reported that prolactin has no effect on zinc-65 uptake by the dorsolateral prostate of the intact rat. Prolactin, however, caused an increase in zinc-65 uptake when the animals were subjected to surgical stress (Rosoff and Martin, 1966).…”

Section: Discussionmentioning

confidence: 99%

“…Prolactin has been reported t o have no effect on the zinc-65 uptake by the prostate and a few other organs in the intact male rat (Rosoff and Martin, 1968).…”

Section: Introductionmentioning

confidence: 99%

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The effect of prolactin on organ weights and zinc‐65 uptake in male baboons

Schoonees¹,

Klerk²,

Murphy³

1970

Journal of Surgical Oncology

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Prolactin in the dosage schedule employed affects the metabolism of zinc-65 as indicated by a reduced uptake of this isotope by most tissues examined following the intravenous administration of Zn6%1,. In this study, however, no evidence was found of a direct effect of prolactin on the prostate in the intact adult male Chacma baboon.In the present study, the effect of prolactin on organ weights and zinc-65 uptake by the prostate and several other tissues were determined in adult male baboons. MATERIAL AND METHODSHealthy adult male Chacma baboons were studied. The animals were kept a t the University of Stellenbosch Primate Project, Bellville, South Africa. On the basis

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Effect of gonadotrophins and of testosterone on organ weights and zinc-65 uptake in the male rat

Cited by 15 publications

References 13 publications

Hormonal effects on zinc concentration and morphology of rat lateral prostate gland

Hormonal effects on zinc concentration and morphology of rat lateral prostate gland

Effects of Pituitary Grafting and CB-154 Treatment on the Growth of Prostates in Mice

The effect of prolactin on organ weights and zinc‐65 uptake in male baboons

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