Effect of Gold Preparations on the Development and Passive Transfer of Experimental Allergic Encephalomyelitis in Rats

Gerber, Robert C.; Whitehouse, M. W.; Orr, K. J.

doi:10.3181/00379727-140-36678

Cited by 20 publications

(3 citation statements)

References 4 publications

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“…It would be tempting to postulate that gold salts assert their beneficial effect on patients by destruction of B cells which produce rheumatoid factor and/or other deleterious antibodies. However, Gerber et a1 (4) have shown that gold preparations delay the develop-…”

Section: To the Editormentioning

confidence: 99%

Gold and the immune system

Measel

1979

Arthritis & Rheumatism

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Section: To the Editormentioning

confidence: 99%

Gold and the immune system

Measel

1979

Arthritis & Rheumatism

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“…The EAE response was monitored by weighing animals daily over the subsequent 10-day interval and observing signs of rear limb paralysis and loss of tail flexion. Further details of these bioassays have geen given elsewhere [2,7].…”

Section: Methodsmentioning

confidence: 99%

Some (pharmacological) properties of chloracetaldehyde, an oxidation product and potential metabolite of cyclophosphamide

1974

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Circumstantial evidence is presented that chloracetaldehyde is generated from cyclophosphamide by chemical oxidation in vitro with peroxide and might possibly be formed in vivo as a product of cyclophosphamide bioaetivalion. Chloracetaldehyde has several attributes of an agent capable of suppressing cellular immunity. Thus it prevents a graft-versus-host reaction (both in vivo and in vitro), is cytostatic and under certain conditions can abrogate an ongoing immunopathy (EAE).These properties are also exhibited by HN-2 and certain alkylating metabolites of cyclophosphamide.

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“…This confusing conclusion nevertheless lends encouragement to the pharmacologist, for one corollary is that the loss of function in EAE may be regulated by drugs other than immunosuppressants and alternative agents which primarily delete or suppress lymphoid populations. There is some evidence that is indeed so [11], including reduction in the paralytic signs by prior defibrination [10].…”

Section: Figurementioning

confidence: 99%