Effect of gold nanoparticles on DNA package in model systems

Skuridin, S. G.; Dubinskaya, V. A.; Rudoy, V. M.; Дементьева, О. В.; Zakhidov, S. T.; Маршак, Т. Л.; Кузьмин, В. А.; Попенко, В. И.; Evdokimov, Yu. M.

doi:10.1134/s1607672910030130

Cited by 22 publications

(14 citation statements)

References 10 publications

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“…This result correlates with the CD spectra shown in Fig. (3), which gives evidence for a decrease in spatial ordering of ds DNA quasinematic layers upon increasing of nano-Au concentration [27]. Hence, one can claim that penetration of nano-Au into structure of quasinematic layers of ds DNA CLCD particles is a condition for collinear alignment of ds DNA molecules, and this process is accompanied by unwinding of helical structure of these particles.…”

Section: Small-angle X-ray Scattering Of Phases Formed By Ds Dna Clcdsupporting

confidence: 74%

“…the nano-Au were negatively charged). One can see that the amplitudes of the bands drop sharply at the increase of the concentration of chemically synthesized nano-Au in the solution [27]. The decrease in the amplitude of the abnormal band in the DNA CLCD CD spectrum starts at the critical concentration of nano-Au, which is approximately 1,000 nano-Au per one DNA CLCD particle and depends on the size of nanoAu [3].…”

Section: Changes In CD Spectra Caused By the Doping Of Dna Clcd Partimentioning

confidence: 94%

“…The latter investigations have been started in 2010 [27], although properties of linear DNA molecules containing ordered nano-Au on their surface were studied since the first influential papers (1996) in this field by C.A. Mirkin and P.A.…”

Section: The Nanotechnological Approach To Creation Of "Rigid" Dna Pamentioning

confidence: 99%

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The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

Yevdokimov¹,

Salyanov²,

Штыкова³

et al. 2014

TONANOJ

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Abstract:Two different approaches to the creation of "rigid" (gel-like) DNA particles (or DNA nanoconstructions) are considered. The physicochemical approach is based on the formation of nanobridges between double-stranded DNA molecules ordered in quasinematic layers of cholesteric liquid-crystalline dispersion (CLCD) particles or their salting-out. This approach represents by itself a "chemical gelation" of DNA molecules realized inside the nanometric DNA particles. The formed "rigid" DNA particles have unique physicochemical properties. The nanotechnological approach is based on induction of "physical gelation" as a result of the formation of Au-clusters in the "free" space between double-stranded DNA molecules ordered in CLCD particles. This approach results in the formation of a new "rigid" DNA material. Its distinctive peculiarity, in contrast to the chemically bonded "rigid" DNA particles, consists in a very weak binding affinity to the nuclear membrane filter used for atomic force microscopy. This opens up a possibility for easy manipulations with CLCD particles doped with gold nanoparticles.Keywords: DNA liquid-crystalline dispersions, nanoconstructions of DNA, nanotechnology of nucleic acids, structure of DNA liquid crystals.

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Section: Small-angle X-ray Scattering Of Phases Formed By Ds Dna Clcdsupporting

confidence: 74%

Section: Changes In CD Spectra Caused By the Doping Of Dna Clcd Partimentioning

confidence: 94%

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The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

Yevdokimov¹,

Salyanov²,

Штыкова³

et al. 2014

TONANOJ

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show abstract

“…Nanoparticle-cell interactions often lead to accidental toxic effects such as blocking of ion channels [58,59], disturbance of the membrane potential induced by nanoporation [60,61], or inhibition of signaling pathways or other essential cell functions such as nuclear chromatin decondensation [62].…”

Section: Cell-nanoparticle Interactions In Generalmentioning

confidence: 99%

Challenges in drug delivery to the brain: Nature is against us

Krol

2012

Journal of Controlled Release

132

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“…The higher the nanoAu concentration, the greater the reduction in abnormal band in CD spectra of dispersions of DNA. (1). Mobility of DNA molecules in quasinematic layers (3) attaches liquid properties to the formed particle (2), and the ordered location of DNA gives crystal properties, i.e.…”

Section: Methodsmentioning

confidence: 99%

Negatively Charged Gold Nanoparticles "Control" Double-Stranded DNAs Spatial Packing

YuM¹,

SG²,

VI³

et al. 2015

Journal of Materials Science and Nanotechnology

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Effect of gold nanoparticles on DNA package in model systems

Cited by 22 publications

References 10 publications

The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

Challenges in drug delivery to the brain: Nature is against us

Negatively Charged Gold Nanoparticles "Control" Double-Stranded DNAs Spatial Packing

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