Effect of gold nanoparticles on depolarization characteristics of Intralipid tissue phantom

Swami, M. K.; Patel, H. S.; Geethu, P. M.; Uppal, Abha; Kushwaha, Pankaj; Gupta, Pradeep Kumar

doi:10.1364/ol.38.002855

Cited by 11 publications

(7 citation statements)

References 10 publications

(19 reference statements)

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“…Considering the intriguing scope of the polarimetric technique for in vivo clinical diagnosis, beside the simulations, there is a need for complex phantoms, such as those exhibiting birefringence (see Fig. 7b (iii)) or depolarisation, to establish reliable processes for investigation of complex scattering mechanisms 270 , 271 . A recent review has summarised various phantoms for both thin and bulk samples 152 .…”

Section: Vectorial Information Analysis For Biomedical Applicationsmentioning

confidence: 99%

Polarisation optics for biomedical and clinical applications: a review

et al. 2021

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Many polarisation techniques have been harnessed for decades in biological and clinical research, each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects. Various advanced vector measurement/sensing techniques, physical interpretation methods, and approaches to analyse biomedically relevant information have been developed and harnessed. In this review, we focus mainly on summarising methodologies and applications related to tissue polarimetry, with an emphasis on the adoption of the Stokes–Mueller formalism. Several recent breakthroughs, development trends, and potential multimodal uses in conjunction with other techniques are also presented. The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

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Section: Vectorial Information Analysis For Biomedical Applicationsmentioning

confidence: 99%

Polarisation optics for biomedical and clinical applications: a review

et al. 2021

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“…For Intralipid tissue phantoms, it was demonstrated that at a given extinction coefficient, the absorption of the GNPs contributes more to the depolarization of the turbid medium. 267 The GNP scattering is significant only for the larger-sized particles. The depolarization of GNPs dominates in the low-scattering phantoms.…”

Section: Nanoparticle Enhancement Of Contrast Of Polarized Light Micrmentioning

confidence: 99%

Polarized light interaction with tissues

2016

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This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.

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“…69 While intralipid suspension exhibits monotonic dependence of depolarization on light wavelength, the use of gold nanoparticles (GNPs) suspended in intralipid creates more complicated depolarization behavior. 90 Titanium dioxide (TiO 2 ) is another material commonly used to produce scattering in optical phantoms. TiO 2 particles have been used in solid host media, such as polydimethylsiloxane or polyurethane, where, before the curing process, these particles are mixed into the polymer.…”

Section: Depolarizing Phantomsmentioning

confidence: 99%

Optical phantoms for biomedical polarimetry: a review

et al. 2019

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Calibration, quantification, and standardization of the polarimetric instrumentation, as well as interpretation and understanding of the obtained data, require the development and use of well-calibrated phantoms and standards. We reviewed the status of tissue phantoms for a variety of applications in polarimetry; more than 500 papers are considered. We divided the phantoms into five groups according to their origin (biological/nonbiological) and fundamental polarimetric properties of retardation, depolarization, and diattenuation. We found that, while biological media are generally depolarizing, retarding, and diattenuating, only one of all the phantoms reviewed incorporated all these properties, and few considered at least combined retardation and depolarization. Samples derived from biological tissue, such as tendon and muscle, remain extremely popular to quickly ascertain a polarimetric system, but do not provide quantifiable results aside from relative direction of their principal optical axis. Microspheres suspensions are the most utilized phantoms for depolarization, and combined with theoretical models can offer true quantification of depolarization or degree of polarization. There is a real paucity of birefringent phantoms despite the retardance being one of the most interesting parameters measurable with polarization techniques. Therefore, future work should be directed at generating truly reliable and repeatable phantoms for this metric determination. Diattenuating phantoms are rare and application-specific. Given that diattenuation is considered to be low in most biological tissues, the lack of such phantoms is seen as less problematic. The heterogeneity of the phantoms reviewed points to a critical need for standardization in this field. Ultimately, all research groups involved in polarimetric studies and instruments development would benefit from sharing a limited set of standardized polarimetric phantoms, as is done earlier in the round robin investigations in ellipsometry.

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Effect of gold nanoparticles on depolarization characteristics of Intralipid tissue phantom

Cited by 11 publications

References 10 publications

Polarisation optics for biomedical and clinical applications: a review

Polarisation optics for biomedical and clinical applications: a review

Polarized light interaction with tissues

Optical phantoms for biomedical polarimetry: a review

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