Effect of GnRHa on plasma levels of Fsh and Lh in the female greater amberjack <i>Seriola dumerili</i>

Nyuji, Mitsuo; Yamamoto, Ikki; Hamada, Kazuhisa; Kazeto, Yukinori; Okuzawa, Koichi

doi:10.1111/jfb.14137

Cited by 15 publications

(4 citation statements)

References 26 publications

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“…Also, in quail, a model avian species, reports clearly state that the effects of GnRH on FSH are smaller than those on LH release 12,13 . This observation raises the same perplexing mystery indicated in teleosts in that GnRH has a small effect on FSH 1,[14][15][16] . Thus, it is postulated that an exclusive FSH-regulating hormone, FSH-RH, exists in vertebrates alongside GnRH.…”

mentioning

confidence: 77%

Identification of the FSH-RH as the other gonadotropin-releasing hormone

Uehara,

Nishiike,

Maeda

et al. 2024

Nat Commun

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In vertebrates, folliculogenesis and ovulation are regulated by two distinct pituitary gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Currently, there is an intriguing consensus that a single hypothalamic neurohormone, gonadotropin-releasing hormone (GnRH), regulates the secretion of both FSH and LH, although the required timing and functions of FSH and LH are different. However, recent studies in many non-mammalian vertebrates indicated that GnRH is dispensable for FSH function. Here, by using medaka as a model teleost, we successfully identify cholecystokinin as the other gonadotropin regulator, FSH-releasing hormone (FSH-RH). Our histological and in vitro analyses demonstrate that hypothalamic cholecystokinin-expressing neurons directly affect FSH cells through the cholecystokinin receptor, Cck2rb, thereby increasing the expression and release of FSH. Remarkably, the knockout of this pathway minimizes FSH expression and results in a failure of folliculogenesis. Here, we propose the existence of the “dual GnRH model” in vertebrates that utilize both FSH-RH and LH-RH.

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mentioning

confidence: 77%

Identification of the FSH-RH as the other gonadotropin-releasing hormone

Uehara,

Nishiike,

Maeda

et al. 2024

Nat Commun

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“…This prevented oocytes from entering OM after the completion of vitellogenesis and finally resulted in oocyte atresia and spawning omission. The effects of the administration of gonadotropin-releasing hormone agonist (GnRHa) on OM and GtH plasma levels were examined in a greater amberjack broodstock of wild origin (Nyuji et al 2019). In fish whose ovaries contained oocyte at the end of vitellogenesis (oocyte diameter >600 lm), a significant increase in plasma concentrations of LH was observed 24 h after treatment, and all treated fish ovulated after 36-42 h, whereas only two out of five untreated control fish spawn spontaneously.…”

Section: Greater Amberjackmentioning

confidence: 99%

Reproduction of greater amberjack (Seriola dumerili) and other members of the family Carangidae

Corriero

Wylie

Nyuji

et al. 2021

Reviews in Aquaculture

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The family Carangidae contains several species of aquaculture interest, including the amberjacks, yellowtails and trevallies. Among them, the greater amberjack (Seriola dumerili), the Japanese amberjack or yellowtail (Seriola quinqueradiata) and the yellowtail kingfish (Seriola lalandi) are considered the species with the highest potential for commercial aquaculture. Understanding the reproductive physiology-biology, spawning kinetics and production characteristics in captivity are of utmost importance for the domestication of any animal, and developing broodstock management methods and therapies to optimize egg production and overcome potential reproductive dysfunctions are essential. The present article reviews the available literature on the reproductive biology of the Carangidae species of interest for the aquaculture industry, both in the wild and under farming conditions. The reproductive traits of wild and farmed fish, whenever available, were compared in order to improve the understanding of the reproductive dysfunctions occurring in captivity. Finally, the hormonal maturation and spawning induction protocols examined so far to ameliorate the reproductive dysfunctions and obtain fertile gametes are summarized, and their effectiveness in the different rearing conditions is discussed.

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“…In the uterus, GnRH has been reported to act as a local regulator involved in the regulation of various uterine functions, including cell proliferation and apoptosis in the uterine endometrial cells, which are critical for menstrual health and successful implantation during pregnancy ( Imai et al., 1998 ; Meresman et al, 2003 ; Guo et al, 2018 ). The function of GnRH in the ovary involves interactions with other local and systemic hormones, specifically it is a modulator of the actions of LH and FSH ( Gong et al, 1995 ; Sonntag et al, 2005 ; Nyuji et al, 2019 ). In addition, it has been reported that GnRH in the uterus is intertwined with other hormonal pathways, such as those involving estrogen and progesterone ( Metallinou et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Gonadotropins Regulate the mRNA Expression of Gonadotropin-Releasing Hormone and Its Receptors in the Mouse Ovary and Uterus

Moon,

Yun,

Lee

et al. 2024

Dev. Reprod.

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Gonadotropin-releasing hormone (GnRH), a critical hormone produced in the hypothalamus, is essential for regulating reproductive processes. It has also been demonstrated the presence of GnRH and its receptors (GnRHR) in ovarian and uterine tissues, but little was known about the regulation mechanism of their expression in these organs and ovarian aging. Therefore, the aim of this study was to investigate the expression of GnRHR in the ovary and uterus of mice, particularly after high-dose gonadotropin treatments and in relation to aging. Quantitative real-time-PCR (qRT-PCR) revealed that pituitary gland had the highest GnRHR expression in both young and aged mice. In addition, liver expression was higher in young mice, whereas thymus expression was higher in aged mice. GnRHR mRNA was present in the ovaries of both young and aged mice but nearly undetectable in the uterus of aged mice. We next examined the expression of GnRHR in the ovary and uterus in response to high-dose administration of pregnant mare serum gonadotropin (PMSG). After PMSG administration, GnRH mRNA levels were significantly decreased in the ovary but increased in the uterus. The expression of GnRH mRNA in these organs showed opposite trends to that of GnRHR expression. These results suggest the involvement of GnRH in age-related reproductive decline and the potential effects of high-dose gonadotropin treatments on reproductive organ function.

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Effect of GnRHa on plasma levels of Fsh and Lh in the female greater amberjack Seriola dumerili

Cited by 15 publications

References 26 publications

Identification of the FSH-RH as the other gonadotropin-releasing hormone

Identification of the FSH-RH as the other gonadotropin-releasing hormone

Reproduction of greater amberjack (Seriola dumerili) and other members of the family Carangidae

Gonadotropins Regulate the mRNA Expression of Gonadotropin-Releasing Hormone and Its Receptors in the Mouse Ovary and Uterus

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