Effect of Glycemic Control on Response to Antiplatelet Therapy in Patients With Diabetes Mellitus and ST-Segment Elevation Myocardial Infarction

Kuliczkowski, Wiktor; Gąsior, Mariusz; Pres, Damian; Kaczmarski, Jacek; Greif, Małgorzata; Łaszewska, Anna; Szewczyk, M.; Hawranek, Michał; Tajstra, Mateusz; Żegleń, Sławomir; Poloński, Lech; Serebruany, Victor L.

doi:10.1016/j.amjcard.2012.03.027

Cited by 16 publications

(15 citation statements)

References 27 publications

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“…However, if we applied the logistic regression analysis in subgroups (Albumin < 35, current smoking, and alcohol abuse), all of them, including genetic and nongenetic causes, association were not found. Comorbidities, such as diabetes mellitus (including the type of diabetes [28] and glycemic control [29]), chronic renal diseases [30] or different renal function grades [31], obesity [31] or elevated body mass index (BMI), heart failure [13], and inflammatory state [32], might be the predictor of poor clopidogrel response. Some of the evidence above was similar to ours.…”

Section: Discussionmentioning

confidence: 99%

Association ofP2Y12Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients

et al. 2014

BioMed Research International

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Background. Clopidogrel inhibits the ADP receptor P2Y12 to keep down the platelet aggregation. The goal of our study is to investigate the contribution of P2Y12 promoter DNA methylation to the risk of clopidogrel resistance (CR). Methods. The platelet functions were measured by the VerifyNow P2Y12 assay. Applying the bisulfite pyrosequencing technology, DNA methylation levels of two CpG dinucleotides on P2Y12 promoter were tested among 49 CR cases and 57 non-CR controls. We also investigated the association among P2Y12 DNA methylation, various biochemical characteristics, and CR. Result. Lower methylation of two CpGs indicated the poorer clopidogrel response (CpG1, P = 0.009; CpG2, P = 0.022) in alcohol abusing status. Meanwhile CpG1 methylation was inversely correlated with CR in smoking patients (P = 0.026) and in subgroup of Albumin < 35 (P = 0.002). We observed that the level of DNA methylation might be affected by some clinical markers, such as TBIL, LEVF, Albumin, AST. The results also showed that the quantity of stent, fasting blood-glucose, and lower HbAC1 were the predictors of CR. Conclusions. The evidence from our study indicates that P2Y12 methylation may bring new hints to elaborate the pathogenesis of CR.

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Section: Discussionmentioning

confidence: 99%

Association ofP2Y12Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients

et al. 2014

BioMed Research International

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“…It was demonstrated that patients with DM and glucose levels above 8.5 mmol/L (154 mg/dL) presenting with STEMI and subjected to PCI have worse response to anti-platelet therapy with clopidogrel [18].…”

Section: Discussionmentioning

confidence: 99%

Diabetic Patients with an Acute Myocardial Infarction in Terms of Risk Factors and Comorbidities Management: Characteristics of the Highest-Risk Individuals

et al. 2016

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“…Also, glycemia is an independent predictor of platelet dependent thrombosis 70 . Moreover, among diabetic patients, those with STEMI and glycemia > 8.5 mmol/L on admission had a poorer response to clopidogrel 76 . Additionally, improved glycemic control reduces platelet reactivity in DM patients after PCI 68 .…”

Section: Putative Pathophysiologic Mechanisms Of Stress Hyperglycemiamentioning

confidence: 98%

Stress hyperglycemia in acute myocardial infarction

Koraćević

Vasiljevic

Veličković‐Radovanović

et al. 2014

VOJNOSANIT PREGL

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Effect of Glycemic Control on Response to Antiplatelet Therapy in Patients With Diabetes Mellitus and ST-Segment Elevation Myocardial Infarction

Cited by 16 publications

References 27 publications

Association ofP2Y12Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients

Association ofP2Y12Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients

Diabetic Patients with an Acute Myocardial Infarction in Terms of Risk Factors and Comorbidities Management: Characteristics of the Highest-Risk Individuals

Stress hyperglycemia in acute myocardial infarction

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