Effect of Glycation on Interlamellar Bonding of Arterial Elastin

Wang, R.; Yu, Xunjie; Gkousioudi, A.; Zhang, Yanhang

doi:10.1007/s11340-020-00644-y

Cited by 11 publications

(5 citation statements)

References 81 publications

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“…The gathered results support the ability of numerical models to provide novel insightful information on the development and growth of several pathological conditions, such as ATAA [12,27] or AD [10,64,89]. Numerical simulations assisted by medical imaging data showed capabilities of estimating in vivo aortic wall material properties [91,93] and WSS [41,80] and WSS distributions [29,39].…”

Section: Discussionsupporting

confidence: 62%

“…Under biaxial conditions, collagen fibres in both directions are similarly loaded and rupture is likely to occur in any direction as well. Wang et al [89] simulated peeling and direct tension tests, aiming to study the effect of glycation (covalent attachment of sugars, usually glucose, to a protein or lipid) on the interlamellar bonding properties of medial elastin, which is often compromised in CVD. The motivation behind this study was the reports of the reduced risk of AD in patients with diabetes.…”

Section: Wall Microstructurementioning

confidence: 99%

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Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

et al. 2022

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Aortic aneurysm is a cardiovascular disease related to the alteration of the aortic tissue. It is an important cause of death in developed countries, especially for older patients. The diagnosis and treatment of such pathology is performed according to guidelines, which suggest surgical or interventional (stenting) procedures for aneurysms with a maximum diameter above a critical threshold. Although conservative, this clinical approach is also not able to predict the risk of acute complications for every patient. In the last decade, there has been growing interest towards the development of advanced in silico aortic models, which may assist in clinical diagnosis, surgical procedure planning or the design and validation of medical devices. This paper details a comprehensive review of computational modelling and simulations of blood vessel interaction in aortic aneurysms and dissection, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). In particular, the following questions are addressed: “What mathematical models were applied to simulate the biomechanical behaviour of healthy and diseased aortas?” and “Why are these models not clinically implemented?”. Contemporary evidence proves that computational models are able to provide clinicians with additional, otherwise unavailable in vivo data and potentially identify patients who may benefit from earlier treatment. Notwithstanding the above, these tools are still not widely implemented, primarily due to low accuracy, an extensive reporting time and lack of numerical validation.

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Section: Discussionsupporting

confidence: 62%

Section: Wall Microstructurementioning

confidence: 99%

Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

et al. 2022

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“…According to many researchers ( Chiou et al, 1999 ; Zhang et al, 2020 ; Wang et al, 2021 ), employing a high concentration of reducing sugar (1 M or higher glucose) in glycation studies is a routine method to accelerate the reaction in vitro . However, serum protein BSA after riboglycation, but not after glucoglycation, caused high cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Effect of ribose-glycated BSA on histone demethylation

Zhang

Yan

et al. 2022

Front. Genet.

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A reducing sugar reacts with the protein, resulting in advanced glycation end-products (AGEs), which have been implicated in diabetes-related complications. Recently, it has been found that both type 1 and type 2 diabetic patients suffer from not only glucose but also ribose dysmetabolism. Here, we compared the effects of ribose and glucose glycation on epigenetics, such as histone methylation and demethylation. To prepare ribose-glycated (riboglycated) proteins, we incubated 150 μM bovine serum albumin (BSA) with 1 M ribose at different time periods, and we evaluated the samples by ELISAs, Western blot analysis, and cellular experiments. Riboglycated BSA, which was incubated with ribose for approximately 7 days, showed the strongest cytotoxicity, leading to a significant decrease in the viability of SH-SY5Y cells cultured for 24 h (IC50 = 1.5 μM). A global demethylation of histone 3 (H3K4) was observed in SH-SY5Y cells accompanied with significant increases in lysine-specific demethylase-1 (LSD1) and plant homeodomain finger protein 8 (PHF8) after treatment with riboglycated BSA (1.5 μM), but demethylation did not occur after treatment with glucose-glycated (glucoglycated) proteins or the ribose, glucose, BSA, and Tris–HCl controls. Moreover, a significant demethylation of H3K4, H3K4me3, and H3K4me2, but not H3K4me1, occurred in the presence of riboglycated proteins. A significant increase of formaldehyde was also detected in the medium of SH-SY5Y cells cultured with riboglycated BSA, further indicating the occurrence of histone demethylation. The present study provides a new insight into understanding an epigenetic mechanism of diabetes mellitus (DM) related to ribose metabolic disorders.

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“…Generally, the structure and the amount of elastin in different types of blood vessels depends on their location in the circulatory system and local hemodynamic conditions. The contribution of elastic structures to vascular biomechanics has been exhaustively studied for decades [ 18 , 20 , 40 , 44 , 53 , 68 ], but new papers are constantly being published [ 15 , 65 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ] showing that there is still room for exploration in this area.…”

Section: Elasticity Of Soft Tissuesmentioning

confidence: 99%

Mechanical Properties and Functions of Elastin: An Overview

Trębacz

Barzycka

2023

Biomolecules

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Human tissues must be elastic, much like other materials that work under continuous loads without losing functionality. The elasticity of tissues is provided by elastin, a unique protein of the extracellular matrix (ECM) of mammals. Its function is to endow soft tissues with low stiffness, high and fully reversible extensibility, and efficient elastic–energy storage. Depending on the mechanical functions, the amount and distribution of elastin-rich elastic fibers vary between and within tissues and organs. The article presents a concise overview of the mechanical properties of elastin and its role in the elasticity of soft tissues. Both the occurrence of elastin and the relationship between its spatial arrangement and mechanical functions in a given tissue or organ are overviewed. As elastin in tissues occurs only in the form of elastic fibers, the current state of knowledge about their mechanical characteristics, as well as certain aspects of degradation of these fibers and their mechanical performance, is presented. The overview also outlines the latest understanding of the molecular basis of unique physical characteristics of elastin and, in particular, the origin of the driving force of elastic recoil after stretching.

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Effect of Glycation on Interlamellar Bonding of Arterial Elastin

Cited by 11 publications

References 81 publications

Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

Effect of ribose-glycated BSA on histone demethylation

Mechanical Properties and Functions of Elastin: An Overview

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