Effect of Glutamic Acid as Additional Monomer in Biodegradable Poly(xylitol Sebacate Glutamate) Polymer

Abstract

Xylitol-based polyesters such as poly(xylitol sebacate) PXS are said to be the potential new materials for tissue engineering due to their adjustable mechanical and degradation properties. However, the result indicates that the elastomers are very soft and have a low elongation at break. Therefore, to increase the mechanical strength and minimize the rate of degradation, glutamic acid was added as the third monomer into the PXS. Novel Poly (xylitol Sebacate Glutamate) (PXSG) was successfully synthesized through melt polycondensation without using any harsh solvents and catalysts. The mixture was synthesized at 120°C for about 8 hours. Post polymerization process was carried out in the oven at 100 °C for three days to develop the crosslink network formation. Several testing and characterization were conducted to evaluate the effect of glutamic acid concentration in the polymer. From the result, FTIR spectroscopy confirmed the ester bond formation, tensile strength and Young's modulus increased significantly while the percent of elongation at break and degradation rate decreased as the glutamic acid ratio increased.

Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications

“…[4][5][6][7] However, it is important to note that PPS bioelastomers are not ideal for long-term applications and may require modifications to their properties for tissue engineering purposes. [8][9][10][11] PPA bioelastomers offer properties similar to PPS polymers for tissue engineering applications, but these polymers have certain limitations too that must be considered. [11][12][13][14][15] Biodegradable xylitol-based elastomers are compelling polymers within this field due to their ability to imitate soft tissue properties.…”

“…These features make them well‐suited for tissue engineering and drug delivery purposes 4–7 . However, it is important to note that PPS bioelastomers are not ideal for long‐term applications and may require modifications to their properties for tissue engineering purposes 8–11 . PPA bioelastomers offer properties similar to PPS polymers for tissue engineering applications, but these polymers have certain limitations too that must be considered 11–15 …”