Effect of Glucose Tolerance Status on PAI‐1 Plasma Levels in Overweight and Obese Subjects

Pannacciulli, Nicola; Mitrio, V. De; Marino, Renato; Giorgino, R; Pergola, Giovanni De

doi:10.1038/oby.2002.98

Cited by 51 publications

(32 citation statements)

References 35 publications

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“…Consistent with the literature, women with MDD and higher PAI-1 concentration were older [26], had higher weight [27], body percent fat [28], and insulin resistance [28], and were physically less fit compared with women with lower PAI-1 concentration. Prothrombotic factors, albeit higher in women with MDD, exhibited the same diurnal variability reported in the literature, with higher levels in the morning compared to the evening [22,23].…”

Section: Discussionsupporting

confidence: 70%

Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk

Eskandari

Mistry²,

Martinez³

et al. 2005

Metabolism

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Section: Discussionsupporting

confidence: 70%

Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk

Eskandari

Mistry²,

Martinez³

et al. 2005

Metabolism

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“…Correlations between HOMA-IR, adiponectin, and PAI-1 were previously reported in both adults (40 -42) and children (43). PAI-1 concentrations are directly influenced by insulin (44), even in situations of insulin resistance (45), a fact that has been explained in terms of abdominal fat, via a higher concentration of cytokines in subjects with central obesity (41). Nevertheless, the association of PAI-1 and insulin resistance has also been found in nonobese cohorts (46).…”

Section: Discussionmentioning

confidence: 83%

Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Ruano

López‐Miranda

Torre

et al. 2007

The American Journal of Clinical Nutrition

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Background: Oxidative stress associated with postprandial lipemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state. Objective: We investigated whether a high concentration of phenols in olive oil can partly reverse this phenomenon. Design: Twenty-one hypercholesterolemic volunteers received 2 breakfasts rich in olive oils with different phenolic contents (80 or 400 ppm) according to a randomized, sequential crossover design. Plasma concentrations of lipid fractions, factor VII antigen (FVIIag), activated factor VII (FVIIa), and plasminogen activator inhibitor-1 (PAI-1) activity were measured at baseline and postprandially. Results: Concentrations of FVIIa increased less (P ҃ 0.018) and plasma PAI-1 activity decreased more (P ҃ 0.021) 2 h after the high-phenol meal than after the low-phenol meal. FVIIa concentrations 120 min after intake of the olive oil with a high phenol content correlated positively with fasting plasma triacylglycerols (P ҃ 0.001), area under the curve (AUC) of triacylglycerols (P ҃ 0.001), and AUC of nonesterified fatty acids (P ҃ 0.024) and negatively with hydroxytyrosol plasma concentrations at 60 min (P ҃ 0.039) and fasting HDL-cholesterol concentrations (P ҃ 0.005). PAI-1 positively correlated with homeostasis model assessment of insulin resistance (P ҃ 0.005) and fasting triacylglycerols (P ҃ 0.025) and inversely with adiponectin (P ҃ 0.026). In a multivariate analysis, the AUCs of nonesterified fatty acids (R 2 ҃ 0.467; ␤: 0.787; SE: 0.02; P 0.001) and adiponectin (R 2 ҃ 0.232; ␤: Ҁ1.594; SE: 0.629; P 0.05) were the strongest predictors of plasma FVIIa and PAI-1, respectively.

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“…Moreover, elevated plasma FFA levels, via producing insulin resistance and hyperinsulinemia, promote a state of increased tendency for thrombosis and decreased ability to fibrinolysis. Together, this substantially increases the risk for acute atherothrombotic events [100][101][102][103][104][105].…”

Section: Hypertriglyceridemia As a Major Component Of Atherogenic Dysmentioning

confidence: 99%

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor

Tenenbaum

Klempfner

Fisman

2014

Cardiovasc Diabetol

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The existence of an independent association between elevated triglyceride (TG) levels, cardiovascular (CV) risk and mortality has been largely controversial. The main difficulty in isolating the effect of hypertriglyceridemia on CV risk is the fact that elevated triglyceride levels are commonly associated with concomitant changes in high density lipoprotein (HDL), low density lipoprotein (LDL) and other lipoproteins. As a result of this problem and in disregard of the real biological role of TG, its significance as a plausible therapeutic target was unfoundedly underestimated for many years. However, taking epidemiological data together, both moderate and severe hypertriglyceridaemia are associated with a substantially increased long term total mortality and CV risk. Plasma TG levels partially reflect the concentration of the triglyceride-carrying lipoproteins (TRL): very low density lipoprotein (VLDL), chylomicrons and their remnants. Furthermore, hypertriglyceridemia commonly leads to reduction in HDL and increase in atherogenic small dense LDL levels. TG may also stimulate atherogenesis by mechanisms, such excessive free fatty acids (FFA) release, production of proinflammatory cytokines, fibrinogen, coagulation factors and impairment of fibrinolysis. Genetic studies strongly support hypertriglyceridemia and high concentrations of TRL as causal risk factors for CV disease. The most common forms of hypertriglyceridemia are related to overweight and sedentary life style, which in turn lead to insulin resistance, metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Intensive lifestyle therapy is the main initial treatment of hypertriglyceridemia. Statins are a cornerstone of the modern lipids-modifying therapy. If the primary goal is to lower TG levels, fibrates (bezafibrate and fenofibrate for monotherapy, and in combination with statin; gemfibrozil only for monotherapy) could be the preferable drugs. Also ezetimibe has mild positive effects in lowering TG. Initial experience with en ezetimibe/fibrates combination seems promising. The recently released IMPROVE-IT Trial is the first to prove that adding a non-statin drug (ezetimibe) to a statin lowers the risk of future CV events. In conclusion, the classical clinical paradigm of lipids-modifying treatment should be changed and high TG should be recognized as an important target for therapy in their own right. Hypertriglyceridemia should be treated.

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Effect of Glucose Tolerance Status on PAI‐1 Plasma Levels in Overweight and Obese Subjects

Cited by 51 publications

References 35 publications

Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk

Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk

Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor

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