The use of the club drugs 3, 4‐methylenedioxymethamphetamine (MDMA, “ecstasy”), gamma‐hydroxybutyrate (GHB), flunitrazepam (Rohypnol), ketamine and LSD is a popular practice among young people especially during all‐night dance parties or “raves“ due to their ability to enhance social experiences and/or alter perception. These substances belong to different classes of drugs: MDMA is an amphetamine derived psychomotor stimulant, Rohypnol is a benzodiazepine, GHB and ketamine are anesthetic drugs while LSD is a hallucinogenic agent and therefore the immediate consequences of their abuse and intoxication can be very different. The long‐term consequences of the abuse of the different club drugs are of great concern. Animal studies indicate that MDMA causes long‐term 5‐HT damage and neuroimaging studies suggest this may also occur in humans. The development of addiction following the use of club drugs is also of concern since several of these drugs have been shown covers the most important aspects of the pharmacology of MDMA and the other club drugs and highlights some of the most important consequences of their abuse.