Effect of Glucagon on Circulating Gastrin

Becker, H. D.; Reeder, David D.; Thompson, James C.

doi:10.1016/s0016-5085(19)33137-3

Cited by 65 publications

(17 citation statements)

References 23 publications

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“…The lower glucagon dose used is probably still 30-50 times higher than the dose which is necessary to achieve glucagon plasma levels in the physiological range (Alford et al, 1974;Gerich et al, 1976). The observed glucagon effect on IR-GIP levels closely resembles the suppressive effect of glucagon on fasting and meal stimulated serum gastrin levels (Becker et al, 1973;Hansky et al, 1973). The effect of glucagon on IR-gastrin has been confirmed in this study with even lower glucagon dosages.…”

Section: Discussionsupporting

confidence: 81%

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Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.

Ebert¹,

Arnold²,

Creutzfeldt³

1977

Gut

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SUMMARY The effect of intravenous glucagon infusion on serum levels of immunoreactive GIP (IR-GIP), insulin (IRI), gastrin (IRG), and on blood glucose has been investigated in six healthy volunteers in the fasting state and during ingestion of a mixed standard meal. Glucagon (500 ng/kg/min) lowered significantly serum levels of IR-GIP and IRG below the fasting values and increased the levels of IRI and blood glucose. Glucagon (50 ng/kg/min) infused 30 minutes before and continued 90 minutes after ingestion of a test meal abolished the IR-GIP response, suppressed significantly the IRG response, and left the IRI response unchanged. The same glucagon dose infused 60 minutes after ingestion of the test meal decreased significantly the raised levels of IR-GIP and IRG to fasting levels without changing IRI values. It is concluded that exogenous glucagon inhibits GIP release at the level of the GIP-producing cells.

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Section: Discussionsupporting

confidence: 81%

“…Secretin (Hansky et al, 1971;Thompson et al, 1972) and glucagon (Becker et al, 1973;Hansky et al, 1973) are able to lower fasting and food stimulated serum gastrin response 'Address for correspondence: Professor Dr. med. W. Creutzfeldt, Medizinische Universittitsklinik, Humboldtallee 1, D-3400 Guttingen, W. Germany.…”

mentioning

confidence: 99%

Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.

Ebert¹,

Arnold²,

Creutzfeldt³

1977

Gut

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“…Various provocation tests have been proposed, such as administration of calcium , secretin (Isenberg et al, 1972;Thompson et al, 1972b), glucagon (Korman, 1973a;Becker et al, 1973), and ingestion of a protein rich meal (Berson and Yalow, 1972). The value of these tests has been studied in small series (Berson and Yalow, 1972;Isenberg et al, 1972;Passaro et al, 1972;Thompson et al, 1972b;Becker et al, 1973;Bradley et al, 1973;Korman et al, 1973a, b;Bonfils et al, 1974) and, recently, in relatively larger groups of ZE patients (Creutzfeldt et al, 1975;Thompson et al, 1975).…”

mentioning

confidence: 99%

“…The value of these tests has been studied in small series (Berson and Yalow, 1972;Isenberg et al, 1972;Passaro et al, 1972;Thompson et al, 1972b;Becker et al, 1973;Bradley et al, 1973;Korman et al, 1973a, b;Bonfils et al, 1974) and, recently, in relatively larger groups of ZE patients (Creutzfeldt et al, 1975;Thompson et al, 1975). However, comparison of the value of different provocation tests in the same patient has not been recorded previously.…”

mentioning

confidence: 99%

Comparative study of the value of the calcium, secretin, and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome.

Lamers¹,

Tongeren²

1977

Gut

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SUMMARY To evaluate the usefulness of provocation tests in the diagnosis of the Zollinger-Ellison (ZE) syndrome stimulation tests with calcium, 15 mg/kg.3 h, and secretin GIH, 1 U/kg.30 s, were performed in 15 patients with histologically proven or suspected ZE syndrome. Nine of these 15 patients were without previous gastric surgery and in them meal stimulated serum gastrin levels were measured as well. These tests were also performed in normal subjects and in patients with duodenal ulcer, antrectomy, total gastrectomy, and achlorhydria. All tests were considered to be positive if a more than a 50 % increase in serum gastrin was found. The results indicate that secretin stimulation is the provocation test of first choice in the diagnosis of this syndrome. This test is most valuable for the following reasons: (1) there were few (two out of 15) false-negative test results in ZE patients; (2) there were no false-positive tests in 69 patients without gastrinoma; (3) it was easy and quick to perform; and (4) there were no adverse reactions. The two ZE patientswithnegativesecretinstimulation tests had negative calcium provocation tests as well, in spite of histologically proven gastrinoma. In 11 patients with suspected or proven ZE syndrome and basal serum gastrin levels of less than 1000 pg/ml a rather good correlation (r = 0-841; p < 0 01) was found between the percental increase in serum gastrin after stimulation by calcium and secretin. Meal stimulated serum gastrin levels are helpful only in patients without previous gastric surgery.

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“…Unlike certain hormonal inhibitors of gastric acid secretion, eg, secretin (Hansky, Soveny, and Korman, 1971) and glucagon (Hansky, Soveny, and Korman, 1973;Becker, Reeder, and Thompson, 1973)), the H2-receptor antagonists, burimamide and metiamide, do not depress basal (Barbezat, Daniel, Bank, Grant, and Vinik, 1974) or food-stimulated (Konturek, Tasler, Obtulowicz, and Rehfeld, 1974) …”

mentioning

confidence: 99%

The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.

Barbezat¹,

Grant²,

Bank³

et al. 1975

Gut

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Effect of Glucagon on Circulating Gastrin

Cited by 65 publications

References 23 publications

Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.

Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.

Comparative study of the value of the calcium, secretin, and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome.

The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.

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