Effect of Ginkgo biloba on lipid profile in hypertensive                 patients on Valsartan monotherapy

Al-Zakaria, Safaa A.; Thanon, Imad A-J; Saadallah, Luma M

doi:10.33899/mmed.2018.160002

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Similarly, the IC 50 value of UA and orlistat to PL was 1.81 ± 0.13 mg/mL and 0.05 ± 0.02 mg/mL, respectively. Although less compared to orlistat, the inhibition efect of UA on CEase was higher than that of ginkgolide B (IC 50 : 0.34 ± 0.02 mg/mL) [36], as well as that of UA on PL was higher than that of betulin (IC 50 : 3.19 ± 0.11 mg/mL) and ginsenoside Rd (IC 50 : 4.06 ± 1.41 mg/mL) [21].…”

Section: Resultsmentioning

confidence: 85%

Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

Jiang,

Huang,

Meng

et al. 2023

Journal of Food Biochemistry

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Ursolic acid (UA) is a natural triterpene carboxylic acid with an underlying anti-hyperlipidemia effect. This study examined the mechanism of interactions of UA with cholesterol esterase (CEase), pancreatic lipase (PL), and micellar cholesterol solubility in vitro. The half-maximal inhibitory concentration (IC50) of CEase, PL, and micellar cholesterol solubility was determined to be 0.07 ± 0.01 mg/mL, 1.81 ± 0.13 mg/mL, and 1.73 ± 0.08 mg/mL, respectively. Multispectral combination revealed that UA changed the secondary structure and quenched the intrinsic fluorescence by static quenching of the two enzymes. The interactions were exothermic reaction as determined by enthalpy. Furthermore, molecular docking confirmed that UA was bound to amino acids of two enzymes at active site through hydrophobic interaction and van der Waals forces. Molecular dynamics (MD) simulation found that CEase and PL rearranged with UA to form stable complexes. The strong inhibition effect of CEase and PL mediated by UA might provide additional insight into understanding the role of UA in the hypolipidemic effect.

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Section: Resultsmentioning

confidence: 85%

Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

Jiang,

Huang,

Meng

et al. 2023

Journal of Food Biochemistry

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“…This observation is consistent with an earlier study that demonstrated the ability of Ginkgo biloba to reduce serum total cholesterol and triglycerides [ 56 ]. Other notable studies showed that GB has an effect on the absorption of triglyceride and cholesterol as well as cholesterol metabolism; a possible explanation for the ability of Ginkgo biloba to lower the level of lipids, and therefore deter the development and progression of artherosclerosis and cardiovascular diseases [ 60 – 62 ]. These prior studies corroborate findings from the current study that show MelB and GB-driven abrogation of T.b.r-induced elevation of cholesterol and triglycerides as well as depletion of HDL.…”

Section: Discussionmentioning

confidence: 99%

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

Wendo,

Mbaria,

Nyariki

et al. 2024

PLoS Negl Trop Dis

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Background The severe late stage Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei rhodesiense (T.b.r) is characterized by damage to the blood brain barrier, severe brain inflammation, oxidative stress and organ damage. Melarsoprol (MelB) is currently the only treatment available for this disease. MelB use is limited by its lethal neurotoxicity due to post-treatment reactive encephalopathy. This study sought to assess the potential of Ginkgo biloba (GB), a potent anti-inflammatory and antioxidant, to protect the integrity of the blood brain barrier and ameliorate detrimental inflammatory and oxidative events due to T.b.r in mice treated with MelB. Methodology Group one constituted the control; group two was infected with T.b.r; group three was infected with T.b.r and treated with 2.2 mg/kg melarsoprol for 10 days; group four was infected with T.b.r and administered with GB 80 mg/kg for 30 days; group five was given GB 80mg/kg for two weeks before infection with T.b.r, and continued thereafter and group six was infected with T.b.r, administered with GB and treated with MelB. Results Co-administration of MelB and GB improved the survival rate of infected mice. When administered separately, MelB and GB protected the integrity of the blood brain barrier and improved neurological function in infected mice. Furthermore, the administration of MelB and GB prevented T.b.r-induced microcytic hypochromic anaemia and thrombocytopenia, as well as T.b.r-driven downregulation of total WBCs. Glutathione analysis showed that co-administration of MelB and GB prevented T.b.r-induced oxidative stress in the brain, spleen, heart and lungs. Notably, GB averted peroxidation and oxidant damage by ameliorating T.b.r and MelB-driven elevation of malondialdehyde (MDA) in the brain, kidney and liver. In fact, the co-administered group for the liver, registered the lowest MDA levels for infected mice. T.b.r-driven elevation of serum TNF-α, IFN-γ, uric acid and urea was abrogated by MelB and GB. Co-administration of MelB and GB was most effective in stabilizing TNFα levels. GB attenuated T.b.r and MelB-driven up-regulation of nitrite. Conclusion Utilization of GB as an adjuvant therapy may ameliorate detrimental effects caused by T.b.r infection and MelB toxicity during late stage HAT.

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“…Also, curcumin can lower total cholesterol, triglycerides and LDL (Lee, 2016), and raising HDL-C, which is associated with lower risk of heart disease. (Qin, 2017 andAl-Zakaria et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The incidence of adding Gingko biloba and Curcumin extracts in drinking water on Body growth, hematological and immune statues of New Zealand White rabbit

Mustafa

Hussein

2023

Tikrit Journal for Agricultural Sciences

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This study was performed to investigate the effect of adding ginkgo biloba (GB) and curcumin extracts in rabbit drinking water, as growth promoter, serum biochemistry, antioxidant enzyme activities and immunoglobin statues. A total of 40 New Zealand White rabbit (NZW) at 5 weeks of age assigned to 4 treatments with four replicates. Gingko biloba (T2) and Curcumin extracts (T3) and their mix (T4) had no significantly differences among all treatments in initial weight, feed and water intake, also in body temperature. While, body weight and body weight gain had significantly (P≤0.05) increased in the all groups of water additive compared with control (T1). As well as FCR (feed conversion ratio) had significantly (P≤0.05) improved in the treatments T2, T3 and T4, compared with the control group T1. Otherwise, the heart rate (beat) was significantly (P≤0.01) decreased in the treatments respectively compared with the control T1. Quite good results were achieved that approve the curcumin and ginkgo biloba extract has a direct influence on the production and blood parameter, improve immunoglobins and antioxidant enzymes concentrations in blood serum.

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Effect of Ginkgo biloba on lipid profile in hypertensive patients on Valsartan monotherapy

Cited by 3 publications

References 20 publications

Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

The incidence of adding Gingko biloba and Curcumin extracts in drinking water on Body growth, hematological and immune statues of New Zealand White rabbit

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