Effect of Ginkgo biloba Leaves Aqueous Extract on Carbon Tetrachloride Induced Acute hepatotoxicity in rats

Khattab, Hala A.H.

doi:10.21608/ejhm.2012.16250

Cited by 2 publications

(2 citation statements)

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“…The impact of GbE on hepatic malondialdehyde (MDA) and reduced glutathione (GSH) in CCl4intoxicated rats was also observed by Khattab [26] . The levels of MDA in the rats' liver tissue were substantially higher in the CCl4-intoxicated group than in the control group, according to the results.…”

Section: Discussionmentioning

confidence: 72%

“…As carbon tetrachloride (CCl4) is one of the most hepatotoxic substances, Khattab [26] reported that GbE was tested for its hepatoprotective potential utilizing CCl4 produced acute hepatotoxicity in rats. The rats intoxicated with CCl4 also showed a substantial reduction in food intake, FER, and weight growth percentage when compared to the control group, according to the results.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Ginkgo biloba on Acrylamide -Induced Rats Hepatotoxicity

Gadalla¹,

Mohamed²,

Thabet³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Hepatotoxicity is the term used to describe harm or liver damage brought on by drug use or other nonpharmacological factors. White crystal chemical acrylamide (ACR) is a typical raw material for polyacrylamide products. Traditional Chinese medicine called Effect of Ginkgo Biloba (EGb) comprises flavonoids and other active ingredients with significant medicinal qualities. Administration of EGb repaired the harm caused by ACR. The protective effect of EGb is achieved by encouraging neuronal regeneration. It is commonly known that EGb works very well to increase antioxidants and blood flow to the brain. Objectives: The aim of the current work was to assess by histological and biochemical tests the potential protective impact of Ginkgo biloba extract against the hepatotoxicity caused by acrylamide. Materials and methods: Forty Wister male albino rats of the local strain of average body weight 160±15 g were used in this study. The experimental healthy animals were housed in separate appropriate cages with a 12-hour light/dark cycle in an environmentally controlled breeding room at a temperature of 22°C and a humidity of 60%, with free access to food and water. Rats were fed a standard diet of processed rat food and water. Liver enzymes and Oxidative stress indicators were measured. Results: Alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase levels were significantly higher in the acrylamide-treated group compared to the untreated, ginkgo biloba-treated, and acrylamide + ginkgo biloba-treated groups (P<0.001). Malondialdehyde levels were also considerably higher in the acrylamide-treated group (20.021.91) compared to the untreated control group (5.220.66), the ginkgo biloba-treated group (4.590.35), and the acrylamide + ginkgo biloba-treated group (8.411.24) (P<0.001). Conclusion:It could be concluded that the hepatoprotective of Ginkgo Biloba action serves as a preventative and therapeutic measure. An aqueous extract of G. biloba leaf contains a variety of chemical components that may function as a mechanism to reduce acute liver damage by scavenging oxidative free radicals, inhibiting lipid peroxidation, and possessing antioxidant activity.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Protective Effects of Ginkgo biloba on Acrylamide -Induced Rats Hepatotoxicity

Gadalla¹,

Mohamed²,

Thabet³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review

Ugwu

Suru

2021

Egypt Liver Journal

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Background Carbon tetrachloride (CCl4) is a well-characterized hepatotoxic agent. With rising cases of liver diseases, the identification, assessment, and development of hepatoprotective agents from plants source has become imperative. Main body With arrays of literature on plants with hepatoprotective potentials, this review sourced published literatures between 1998 and 2020 and systematically highlighted about 92 medicinal plants that have been reported to protect against CCl4-induced liver injury in animal models. The results show that herbal plants provide protection for the liver against CCl4 by downregulation of the liver marker enzymes and activation of antioxidant capacity of the liver cells with the restoration of liver architecture. We also provided the traditional and accompanying pharmacological uses of the plants. A variety of phytochemicals mostly flavonoids and polyphenols compounds were suggested to offer protection against liver injuries. Conclusion It can be concluded that there are a variety of phytochemicals in plant products with hepatoprotective activity against CCl4-induced toxicity in animal models.

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Effect of Ginkgo biloba Leaves Aqueous Extract on Carbon Tetrachloride Induced Acute hepatotoxicity in rats

Cited by 2 publications

References 44 publications

Protective Effects of Ginkgo biloba on Acrylamide -Induced Rats Hepatotoxicity

Protective Effects of Ginkgo biloba on Acrylamide -Induced Rats Hepatotoxicity

Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review

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