Effect of Ginkgo biloba extract, EGb 761, on the cellular immune response in a hypothalamic?pituitary?adrenal axis activation model in the rat

The effects of Ginkgo biloba extract added to haloperidol on peripheral T cell subsets in drug-free schizophrenia: a double-blind, placebo-controlled trial

“…To our knowledge, this is the first study reporting the beneficial effects of EGb on immune system in human, which is in agreement with a few recent reports in animals (Puebla-Perez et al 2003;Tian et al 2003). Our present study provided convincing evidence that EGb may, at least partially, restore peripheral immune functions in schizophrenia.…”

“…Although a great deal of attention has focused on its free radical scavenging properties to have antioxidant effects and its plateletactivating factor receptor antagonist properties to increase cerebral blood flow, the other properties may also be important. Recently, Puebla-Perez et al (2003) evaluated the effects of EGb on the cellular immune response in rats with immunosuppression induced by chronic stress. They found that the cellular immune responses of immunosuppressed rats receiving EGb were restored almost to control group values.…”

Aspirin and immune system

“…Compelling data emerging from prior research now indicates that alterations in neuroendocrine hormonal release from HPA axis may also possess immunoregulatory impacts on the immune system, particularly, in restraining or shaping the immune responses in a variety of inflammatory/autoimmune conditions [150][151][152][153]. Pharmacologically, activity of HPA axis can be altered by a variety of drugs having different mechanisms of action, including ginkgo biloba [154,155], ethanol [156], and COX inhibitors [157][158][159]. ASA was shown to augment the effects of naloxone [160] and to inhibit those of vasopressin [161] upon the hormonal secretion (ACTH and cortisol) from the HPA axis, which were suggested to be mediated by its COXinhibitory mechanism affecting the synthesis of endogenous PGs that play an important role in the inflammation-induced activation and responsiveness of HPA axis [162,163].…”

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

“…Contact hypersensitivity (CHS) experimental models are commonly used in rodents to investigate possible anti-inflammatory agents (Verdrengh et al 2003;Wee et al 2005;Puebla-Pérez et al 2003). CHS is one of the forms of delayed type of hypersensitivity (DTH) which is a T-cell-mediated, antigen-specific skin inflammation induced by skin exposure to hapten (e.g.…”