Effect of ginger tea on chemotherapy-induced nausea and vomiting among cancer patients in selected hospitals, Bhubaneswar, Odisha

Abstract

A quasi-experimental research study (posttest only research design) was conducted to evaluate the effect of ginger tea on chemotherapy-induced nausea and vomiting among cancer patients in selected hospitals of Bhubaneswar and to find out the association of level of chemotherapy-induced nausea and vomiting with selected socio-demographic variables. For this study, a quantitative experimental approach and post-test only research design was adopted. 100 patients were selected by convenience sampling technique and categorized into experimental (n=50) and control group (n=50) for this study. Self- structured socio-demographic proforma and self- structured record analysis proforma was used to collect socio-demographic data and modified nausea and vomiting scale was used to measure the level of chemotherapy-induced nausea and vomiting among cancer patients. The data was analyzed by using SPSS version 20.0 (Statistical Package for the Social Science). The post-testt level of chemotherapy-induced nausea and vomiting among experimental and control groups was compared by unpaired‘t’ test and the result showed (p=<0.0001) significant difference between both groups. The chi-square analysis shows a statistically significance association between chemotherapy-induced nausea and vomiting and the emetogenic potential of the drug in both groups and in control group age was also significance associated. The ANOVA test revealed the statistically significance of the posttest level of chemotherapy-induced nausea and vomiting within groups of the emetogenic potential of a drug. The present study concluded that the food component, like ginger tea, is an effective home remedy for the reduction of chemotherapy-induced nausea and vomiting among cancer patients. Further study can be conducted with a large population, different dose and compositions of ginger and with different adjuvant therapy to manage nausea and vomiting among cancer patients.

A Quasi-Experimental Study of the Effect of Ginger Tea on Preventing Nausea and Vomiting in Patients With Gynecological Cancers Receiving Cisplatin-Based Regimens

“…This is one of the few experimental studies conducted to evaluate the antiemetic effect of ginger tea in preventing chemotherapy-related nausea and vomiting in gynecological cancers. The results showed that ginger tea had a significant beneficial effect in reducing the experience, development, and distress of nausea, vomiting, and retching induced by cisplatin-based regimens, which is consistent with 1 study conducted in India 5 . A controlled trial in patients with gynecological cancer receiving cisplatin-based regimens also showed that 1.0 g of ginger reduced delayed nausea and vomiting as effectively as 40 mg metoclopramide per day but had no effect on preventing acute nausea and vomiting 23 .…”

“…The results showed that ginger tea had a significant beneficial effect in reducing the experience, development, and distress of nausea, vomiting, and retching induced by cisplatin-based regimens, which is consistent with 1 study conducted in India. 5 A controlled trial in patients with gynecological cancer receiving cisplatin-based regimens also showed that 1.0 g of ginger reduced delayed nausea and vomiting as effectively as 40 mg metoclopramide per day but had no effect on preventing acute nausea and vomiting. 23 This effectiveness has been confirmed by some studies, although others have shown contrary results.…”

“…2 The most frequent and distressing toxicities associated with chemotherapy in patients with cancer are nausea and vomiting, despite antiemetic treatment such as granisetron and dexamethasone. [3][4][5] Chemotherapy-induced nausea and vomiting (CINV) can be observed within the first 24 hours after chemotherapy (acute) and also persist up to 72 hours to 5 days after chemotherapy (delayed). 6 Several studies have shown that sociodemographic, clinical, and genetic characteristics contribute to individual differences in the development of CINV.…”

“…6 Several studies have shown that sociodemographic, clinical, and genetic characteristics contribute to individual differences in the development of CINV. 5,7,8 For example, younger age was significantly associated with the development of acute nausea; being single, having an advanced stage of cancer, and receiving highly emetogenic chemotherapy were significantly associated with the development of delayed nausea. 8 A highly emetogenic chemotherapy drug is cisplatin, a cornerstone in many chemotherapy regimens for the treatment of various cancers, including gynecological cancers.…”

“…Chemotherapy-induced nausea and vomiting (CINV) can be observed within the first 24 hours after chemotherapy (acute) and also persist up to 72 hours to 5 days after chemotherapy (delayed) 6 . Several studies have shown that sociodemographic, clinical, and genetic characteristics contribute to individual differences in the development of CINV 5,7,8 . For example, younger age was significantly associated with the development of acute nausea; being single, having an advanced stage of cancer, and receiving highly emetogenic chemotherapy were significantly associated with the development of delayed nausea 8 .…”