Effect of ghrelin on autonomic activity in healthy volunteers

Soeki, Takeshi; Koshiba, Kunihiko; Niki, Toshiyuki; Kusunose, Kenya; Yamaguchi, Koji; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Shimabukuro, Michio; Minakuchi, Kazuo; Kishimoto, Ichiro; Kangawa, Kenji; Sata, Masataka

doi:10.1016/j.peptides.2014.09.015

Cited by 21 publications

(19 citation statements)

References 21 publications

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“…The average decreases in sBP and dBP from baseline were 5.2 ± 1.7 and 5.9 ± 1.5 mmHg, respectively. We found a similarly modest, but significant decrease in HR that has been noted in some, but not all, human studies as well as rodent studies (35,37). The discrepancies in HR effects between studies may be due to differences in AG doses or mode of administration.…”

Section: Discussionsupporting

confidence: 85%

“…Several clinical studies have demonstrated decreased arterial pressure following AG given as IV bolus or infusion (19,35,36). Our study, novel in its continuous monitoring of systemic BP and HR over a 3-hour infusion period, supports these previous findings as AG infusion lowered both sBP and dBP.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral ghrelin administration can suppress cardiac sympathetic nervous activity, increase parasympathetic activity, and prevent early left ventricular remodeling in rats after myocardial infarction (39). Similarly in humans, peripheral AG bolus injection decreases parameters of sympathetic nervous activity while increasing measures of parasympathetic nervous activity during Holter monitoring (35). Our findings of simultaneous decreases in BP and HR suggest that AG decreases sympathetic and/or increases parasympathetic outflow to the CV system.…”

Section: Discussionmentioning

confidence: 99%

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Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans

Zhang

Bidlingmaier

Altaye

et al. 2017

European Journal of Endocrinology

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Objective To compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR), and other autonomic parameters in healthy humans and to elucidate hormonal mechanisms through which AG could exert cardiovascular (CV) effects. Design 17 healthy participants underwent frequent monitoring of systolic (sBP) and diastolic blood pressure (dBP), HR, respiratory rate (RR), and body surface temperature (Temp) during continuous infusion of AG, DAG, combined AG+DAG, or saline control before and during an IV-glucose tolerance test on 4 separate days. Plasma catecholamines, renin, and aldosterone levels were also measured. Differences in outcome measures between treatment groups were assessed using mixed model analysis. Results Compared to the saline control, AG and combined AG+DAG infusions decreased sBP, dBP, mean arterial blood pressure (MAP), HR, and Temp. In contrast, DAG infusion did not alter BP, RR, or Temp, but did decrease HR. The AG and AG+DAG infusions also raised plasma aldosterone levels compared to saline (p < 0.001) without affecting renin or catecholamine levels. Conclusions The decrease in BP, HR, RR, and Temp with AG infusion suggests mediation through the autonomic nervous system. The lack of response to DAG suggests that these autonomic effects require activation of the ghrelin receptor.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans

Zhang

Bidlingmaier

Altaye

et al. 2017

European Journal of Endocrinology

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“…Over the last decade numerous studies have consistently reported that ghrelin has the ability to not only modulate SNA under normal conditions (16,17), but more importantly, play a critical role in attenuating or even preventing the increase in SNA following acute MI (5,6,13,18). The role of the vagal afferent pathways remains less certain as discussed below.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin Supresses Sympathetic Hyperexcitation in Acute Heart Failure in Male Rats: Assessing Centrally and Peripherally Mediated Pathways

et al. 2015

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The hormone ghrelin prevents a dangerous increase in cardiac sympathetic nerve activity (SNA) after acute myocardial infarction (MI), although the underlying mechanisms remain unknown. This study aimed to determine whether ghrelin's sympathoinhibitory properties stem either from directly within the central nervous system, or via modulation of specific cardiac vagal inhibitory afferents. Cardiac SNA was recorded in urethane-anesthetized rats for 3 hours after the ligation of the left anterior descending coronary artery (ie, MI). Rats received ghrelin either sc (150 μg/kg) or intracerebroventricularly (5 μg/kg) immediately after the MI. In another two groups, the cervical vagi were denervated prior to the MI, followed by sc injection of either ghrelin or placebo. Acute MI induced a 188% increase in cardiac SNA, which was significantly attenuated in ghrelin-treated rats for both sc or intracerebroventricularly administration (36% and 76% increase, respectively). Consequently, mortality (47%) and the incidence of arrhythmic episodes (12 per 2 h) were improved with both routes of ghrelin administration (<13% and less than five per 2 h, respectively). Bilateral vagotomy significantly attenuated the cardiac SNA response to acute MI (99% increase). Ghrelin further attenuated the sympathetic response to MI in vagotomized rats so that the SNA response was comparable between vagotomized and vagal-intact MI rats treated with ghrelin. These results suggest that ghrelin may act primarily via a central pathway within the brain to suppress SNA after MI, although peripheral vagal afferent pathways may also contribute in part. The exact region(s) within the central nervous system whereby ghrelin inhibits SNA remains to be fully elucidated.

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“…found no significant association between ghrelin and psychologic factors, they did not specifically evaluate the PDS subtype . Of note, ghrelin infusion has been shown to alter the sympathetic/parasympathetic balance in healthy adults …”

Section: Discussionmentioning

confidence: 98%

Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post‐prandial distress syndrome

Hijaz

Friesen

Schurman

et al. 2015

Neurogastroenterology Motil

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Effect of ghrelin on autonomic activity in healthy volunteers

Cited by 21 publications

References 21 publications

Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans

Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans

Ghrelin Supresses Sympathetic Hyperexcitation in Acute Heart Failure in Male Rats: Assessing Centrally and Peripherally Mediated Pathways

Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post‐prandial distress syndrome

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