Effect of gestational nicotine treatment on newborn rat retina: a histopathological and morphometric analysis

Evereklioğlu, Cem; Özkırış, Abdullah; Alaşehirli, Belgin; Sarı, İbrahim; Güldür, Emin; Cengiz, Beyhan; Kontaş, Olgun

doi:10.1046/j.1475-1313.2003.00148.x

Cited by 20 publications

(24 citation statements)

References 34 publications

(40 reference statements)

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“…The posterior lens capsule does not have this layer and appears smooth and thin. The migration of the lens epithelial cells over the posterior lens capsule behind the equator is responsible for the formation of posterior subcapsular cataract [9]. In the present study prenatal isotretinoin treatment during day 12-18 showed similar findings in many rats.…”

Section: Discussionsupporting

confidence: 82%

Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Premchandran¹,

Madhyastha²,

Saralaya³

et al. 2013

iosrphr

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Section: Discussionsupporting

confidence: 82%

Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Premchandran¹,

Madhyastha²,

Saralaya³

et al. 2013

iosrphr

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“…15 This enhancement of the antihypoxia defence system because of excessive intrauterine hypoxia is speculated to be another possible mechanism that reduces the incidence of severe ROP. Recent reports demonstrated an increase in haemeoxygenase 1 and 2 expressions in the placenta of smoking mothers, and increased levels of ceruloplasmin in the plasma of newborns and mothers exposed to tobacco smoking.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity

Hirabayashi

Honda

Morioka

et al. 2009

Eye

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Purpose In this study, the effects of maternal smoking along with other clinical risk factors in developing severe retinopathy of prematurity (ROP) were evaluated. Design A case-control study. Methods Records of newborn infants with an estimated postmenstrual age of 32 weeks or less (n ¼ 86) were reviewed. ROP grading was evaluated in accordance with the International Classification of Retinopathy of Prematurity. Severe ROP was diagnosed when it progressed to stage 3 with plus disease. The factors were first evaluated using a univariate logistic regression analysis between the groups of severe and non-severe ROP, followed by a multivariate logistic regression analysis using STATA version 10 and R version 2.71. Results A low birth weight, a long duration of artificial ventilation and oxygen supplementation, presence of chronic lung disease, and absence of maternal smoking were found to be significantly associated with severe ROP in the univariate logistic regression analysis. In the multivariate logistic regression analysis, maternal smoking was revealed as a significant factor independently associated with the incidence of severe ROP. Conclusions An inhibitory effect of maternal smoking against developing severe ROP is suggested. The mechanism by which smoking may reduce the incidence of severe ROP needs to be further investigated.

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“…The study was performed using New Zealand white albino rabbits weighing between 3.0 and 3.5 kg, and experiments were conducted in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research [15,16,17]. The rabbits were randomly divided into four groups, and each group consisted of 10 eyes of 10 rabbits.…”

Section: Methodsmentioning

confidence: 99%

Deep Sclerectomy with Various Implants: An Experimental and Histopathologic Study in a Rabbit Model

Erkılıç

Özkırış²,

Evereklioğlu³

et al. 2004

Ophthalmologica

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Background and Objective: To investigate the effectiveness of various implants used in experimental deep sclerectomy and to report tissue reactions developed to these implants histopathologically. Materials and Methods: Forty eyes of 40 New Zealand white albino rabbits underwent deep sclerectomy with various implants. The rabbits were divided into four groups; each consisted of 10 eyes. Deep sclerectomy was performed using copolymer materials in group 1, silicone materials in group 2 and chromic catgut suture in group 3. No implants were used in the control group (group 4). Clinical and histopathological examinations were performed to investigate the effectiveness of implants. Results: Mean preoperative intraocular pressure (IOP) was 14.4 ± 1.6 mm Hg in group 1, 14.5 ± 1.8 mm Hg in group 2, 13.8 ± 1.5 mm Hg in group 3 and 14.5 ± 1.2 mm Hg in group 4. The final postoperative IOPs were 10.7 ± 0.9, 10.6 ± 0.8, 13.5 ± 1.0, and 14.5 ± 1.4 mm Hg, respectively. At 2 months, the decrease in IOPs from baseline and the persistence of the filtering bleb were significantly marked in group 1 and group 2 (p < 0.001). Histopathological evaluation revealed that copolymer and silicone materials formed a smooth and regular intrascleral space. There were no foreign body reaction, tissue destruction or fibrosis in group 1 and group 2, but chromic catgut sutures caused severe fibrosis and inflammatory reaction in group 3. Mean histopathologic score of group 1, group 2, group 3 and group 4 was 0.7 ± 0.5, 0.8 ± 0.5, 2.4 ± 0.6, and 0.1 ± 0.3, respectively. Conclusion: Copolymer or silicone materials may increase the success rate of surgery by maintenance of a large and regular intrascleral space after deep sclerectomy and prevention of collapse of the flap.

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Effect of gestational nicotine treatment on newborn rat retina: a histopathological and morphometric analysis

Cited by 20 publications

References 34 publications

Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity

Deep Sclerectomy with Various Implants: An Experimental and Histopathologic Study in a Rabbit Model

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