Effect of germination on anticancer activity of Trigonella foenum seeds extract

Abas, Al-Shimaa M.; Naguib, Deyala M.

doi:10.1016/j.bcab.2019.101067

Cited by 20 publications

(5 citation statements)

References 25 publications

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“…Dry and sprouted fenugreek seeds aqueous extract potentially inhibited MCF-7 cell growth and pancreatic cell growth. The sprouted extract reduces MCF-7 and AsPC-1 cell viability higher than dry seed extract and enhances the activity of caspase-3, caspase-6, and DNA fragmentation [67].…”

Section: Antineoplastic Effects Of Fenugreekmentioning

confidence: 88%

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

2020

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Fenugreek seeds have widespread relations with Ayurveda, Unani, and Arabic medicine. The seeds were useful for the treatment and prevention of different ailments. Fenugreek (Trigonella foenum-graecum) or methi is from the Leguminosae family and are primarily known for its anti-diabetic and hypocholesterolemic activities. The germinated fenugreek seeds were used in the treatment of E.coli infection in Germany and France. The important phytoconstituents responsible for such medicinal applications are saponins, polyunsaturated fatty acids, galactomannans, trigonelline, and 4-hydroxy isoleucine. Flavonoids, apigenin 6,8-di-C-glucoside, apigenin-6-C-glucosyl-8-C-galactoside, 6-Cgalactosyl- 8-C-arabinoside are the chief ingredients of fenugreek seeds; responsible for reducing blood glucose while given to diabetic rats, whereas important flavones are epigenin, luteolin and vitexin. The other major bioactive components in fenugreek seeds are polyphenols like rhaponticin and isovitexin. Fenugreek seeds contain phosphorus and are categorized into different classes such as inorganic phosphorus, phospholipids, phytates, phosphor-proteins, and nucleic acid. Germinated seeds profusely filled with amino acids with amino acids, proteins, ascorbic acid, sugars. Further, this review shares information about the recent therapeutic intervention not covered earlier; on in vivo and in vitro and some clinical applications against certain interesting ailments other than older applications. This review includes certain nano delivery systems of Fenugreek seeds and their medicinal application.

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Section: Antineoplastic Effects Of Fenugreekmentioning

confidence: 88%

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

2020

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“…The antioxidant activity of the extract was carried out by the free radical DPPH method where vitamin C (0.01–0.1 mg) was used as a reference according to previous report [6] . To investigate the anticancer activity of n-hexane extract of nutmeg root, the breast cancer (MCF-7) cells was obtained from Animal Study Center in Institut Pertanian Bogor, Indonesia according to ATCC protocols [7] has been carried out at various concentrations of 25, 50, 100, and 200 ppm. As a positive control, the doxorubicin was employed, where the cells were grown at a concentration of 5000 cells in 100 µL growth medium.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Lignan compound isolated from n-Hexane extract myristica fragrans Houtt root as antioxidant and antitumor activities against MCF-7 cell lines data

et al. 2020

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Nutmeg plant (Myristica fragrans Houtt) is known as one of traditional medicine. The nutmeg root has a strong potential in antioxidant and anticancer agents among other nutmeg plant parts. The n-hexane root extract has been carried out by thin-layer chromatography and obtained 8 fractions (labeled as Myristica fragrans Houtt Root: MFHR 1 − 8). Specifically, the MFHR 4 has been purified for several times to obtain a yellow-brown color. Furthermore, lignan compound 6′-methyl-(7‑hydroxy-8-methylbut-9-en)-3,2′-dimethoxybiphenyl-4,5-diol) was identified with chemical formula of C 20 H 24 O 5 and analyzed using UV–vis spectroscopy, fourier-transform infrared spectroscopy (FTIR), 1D/2D nuclear magnetic resonance (NMR), and liquid chromatography–mass spectrometry (LC-MS). Based on MTT assay, MFHR demonstrated moderate anticancer activity against MCF-7 cell lines of 51.95 µM, meanwhile, DPPH activity confirmed the strong antioxidant activity with IC50 value of 12.67 ppm.

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“…Fenugreek extracts has significant effect on cell viability, increase caspase3 and 6 concentration and LDH activity and caused nucleosomal DNA fragments. Germination increased the phytochemical components such as flavonoids, tannins, steroids, alkaloids, phenolics and trigonelline of the extract which are believed to have antitumor activity [15].…”

Section: Anticancer Activitymentioning

confidence: 99%

A therapeutic approach of trigonella foenum graceum – a brief overview

M¹,

Meera²,

Nikitha³

et al. 2022

J Integral Sci

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Trigonella foenum graceum has a place in the fabaceae family fenugreek. It is composed of a variety of alkaloids, saponins, flavonoids, free fatty acids and lipids, vitamins, minerals mucilage and fibres. Trigonella foenum graceum have hepatoprotective activity, antioxidant activity, mast cell stabilizing activity, anticancer activity, antibacterial activity, cardioprotective effect and antigenotoxic activity. Traditional medicine in India and other parts of the globe has used Trigonella foenum graceum as carminative, lactation stimulant, laxative, antidiabetic effect, hypocholesterolemic influence, antioxidant potency, digestive stimulant action and hepatoprotective effect.

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Effect of germination on anticancer activity of Trigonella foenum seeds extract

Cited by 20 publications

References 25 publications

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

Lignan compound isolated from n-Hexane extract myristica fragrans Houtt root as antioxidant and antitumor activities against MCF-7 cell lines data

A therapeutic approach of trigonella foenum graceum – a brief overview

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