Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice

Abstract

Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 µL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 µL of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% GC oil was applied daily (70 µL, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The GC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate GC oil's immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.

Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice

“…2,4-Dinitrochlorobenzene induces hemorrhages, itching, edema, scarring, dryness, and AD-like skin lesions on the face, nose, ears, neck, and back of BALB/c and NC/Nga mice (Lee et al, 2010;Choi et al, 2012).…”

Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress

“…Chamomile also contains high levels of coumarins, hydroxycoumarins, terpenoids, and is one of the richest sources of dietary antioxidants (McKay and Blumberg, 2006; Srivastava et al, 2010; Kato et al, 2008; Carnat et al, 2004). In cell culture, chamomile has been demonstrated to modulate the production of many pro-inflammatory mediators such as superoxide anion, tumor necrosis factor-alpha, interleukins and prostaglandins by selectively targeting cyclooxygenase-2 (Yoo et al, 2009; Smolinski and Pestka, 2003; Lee et al, 2010; Srivastava et al, 2009). We have demonstrated that chamomile inhibits the production of nitric oxide and inducible nitric oxide synthase in a dose-dependent manner without causing toxicity to murine macrophages (Bhaskaran et al, 2010).…”

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

“…Patients in the essential oil group experienced a lower scratching frequency compared to patients in the control group [38]. Peristomal skin problems can cause numerous unpleasant symptoms such as skin discoloration, pain, full-thickness wounds and itching.…”