Effect of geraniol against arecoline induced toxicity in the third instar larvae of transgenicDrosophila melanogaster (hsp70-lacZ) Bg⁹

Enhancing the Antipsychotic Effect of Risperidone by Increasing Its Binding Affinity to Serotonin Receptor via Picric Acid: A Molecular Dynamics Simulation

“…In addition, Leu325, Ala321, Ala108, and Ala176 established π-alkyl interactions while Asp172 formed a halogen (fluorine) interaction [ 27 , 28 ]. The best-docked pose of [(Ris) (PA)]-dopamine revealed that the amino acid residues, including Thr142, Ala185, His393, and Tyr408, formed hydrogen bond interactions, Val115 and Phe389 established π-alkyl interactions, Trp386 established π-sigma, and Cys118 formed a halogen (fluorine) interaction [ 29 , 30 ]. The best-docked pose of the [(Ris) (PA)]-adrenergic receptor interaction revealed that the amino acid residues Val414, Asp206, Asp131, and Ser218 formed hydrogen bond interactions, while Phe398, Phe423, and Cys135 established π-alkyl interactions, and Val132 and Ser214 established π-sigma and halogen (fluorine) interactions, respectively.…”

“…Analysis of the best-docked pose of [(Ris) (PA)]-serotonin revealed that the amino acid residues, including His182, Asn187, Asn384, Lys320, and Arg173, formed hydrogen bond interactions. In addition, Leu325, Ala321, Ala108, and Ala176 established π-alkyl interactions while Asp172 formed a halogen (fluorine) interaction [28,29]. The best-docked pose of [(Ris) (PA)]-dopamine revealed that the amino acid residues, including Thr142, Ala185, His393, and Tyr408, formed hydrogen bond interactions, Val115 and Phe389 established π-alkyl interactions, Trp386 established π-sigma, and Cys118 formed a halogen (fluorine) interaction [30,31].…”

Spectroscopic and Molecular Docking Studies of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Anticonvulsant Therapeutic Agent Gabapentin

“…As shown in Figure 8a, CuGS showed that the residues Arg173, Thr109, His182, and Asn187 had established hydrogen bonds. Additionally, Asp172 (Attractive charge) and Ala176 and Arg173 (Alkyl) interactions could also be seen [40,41]. Similarly, docking of the Gpn drug with serotonin and dopamine gave the potential binding energy of −5.1 and −4.8 kcal/mol, respectively.…”

Protective effect of the newly synthesized and characterized charge transfer (CT) complex against arecoline induced toxicity in third-instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9: experimental and theoretical mechanistic insights

“…[5][6][7][8][9] We have studied the toxicity of arecoline and the protective effect of natural plant products (Geraniol) in the third instar larvae as well as adult flies of the transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 . [10][11][12] The toxic effects of arecoline could be reduced by using natural plant products and the supplementation of various vitamins. 13 The charge transfer complexes (CTCs) are self-assembled organic materials formed from the interaction between donor and p-acceptor moieties through N + -HÁ Á ÁO À bonding, and this concept was first introduced by Mulliken and Foster.…”

“…5–9 We have studied the toxicity of arecoline and the protective effect of natural plant products (Geraniol) in the third instar larvae as well as adult flies of the transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 . 10–12 The toxic effects of arecoline could be reduced by using natural plant products and the supplementation of various vitamins. 13…”