Effect of genotype and practice upon behavioral development in mice

Fuller, John L.; Herman, Barry K.

doi:10.1002/dev.420070105

Cited by 42 publications

(32 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to the results of Fuller and Herman (1974) which suggested a high degree of concordance among the BWS lines with respect to brain weight and psychomotor maturation, the present data indicate that H-line mice show within-session improvement of correct choice-point turns as well as 24-hr retention of that training at an earlier age than do the M-and L-lines. In addition, M-and Lline mice with similar brain growth functions first demonstrate within-session improvement in correct turns at the same age.…”

Section: Discussionsupporting

confidence: 90%

“…The importance of genic factors in influencing maturation has also been suggeste-d by investigations involving ontogenetic behavioral comparisons among strains of mice (Groswald & Luttges, 1975;Meier, 1964;Nagy, Misanin, & Wetzel, 1973), though relatively few studies have utilized this approach. Recent research using a 3rd genetic technique has demonstrated that in mice genetically selected for differences in brain weight, genes regulating brain growth also influence behavioral development (e.g., Fuller &Herman, 1974).Results of experiments from 2 brain-weight selection programs, created to explore a number of genetically based brain-behavior relationships in both neonatal and adult mice, …”

mentioning

confidence: 99%

See 1 more Smart Citation

Development of learning and memory in mice genetically selected for differences in brain weight

Herman

Nagy

1977

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

Mice selected for high (H), medium (M), and low (L) brain weight were trained to the goal arm opposite their preference in a shock-escape T-maze at 7, 9, 11, or 13 days of age. Twenty-four hours later, half of the trained groups at each age received additional training to the original goal, whereas the other half was trained to the opposite goal. Maturational control groups without prior training were trained on the selected retest days for the previously trained groups. Improvement in correct choice-point turns during training was suggested for the H-line by 9 days of age and by 11 days of age for the M- and L-lines. During retraining, H-line mice demonstrated 24-hr retention effects by 10 days of age, whereas 24-hr memory was not indicated for M- and L-lines at any of the ages investigated. These results indicate that the onsets of learning and memory were influenced by genes affecting brain weight, in that H-line mice demonstrated more rapid brain growth as well as heavier brain weights at every age studied as compared with M- and L-line mice which showed similar brain growth functions.

show abstract

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Development of learning and memory in mice genetically selected for differences in brain weight

Herman

Nagy

1977

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The Fuller lines were genetically selected for differential brain size; they include a high line (H), a low line (L), and a medium line (M) (Fuller & Herman, 1974). The H and L lines were chosen for this experiment because they exhibit differential rates of neural and behavioral development (Fuller & Herman, 1974;.…”

Section: Subjectsmentioning

confidence: 99%

Passive avoidance during brain-growth spurts and plateaus

Lavooy

Hahn

et al. 1981

Bull. Psychon. Soc.

View full text Add to dashboard Cite

Epstein has suggested that normal brain development is characterized by spurts and plateaus. In mice, these spurts seem to appear at 0-6,8-12 or 13, and 17-23 days, and plateaus appear at 6-8,12-17, and after 23 days of age. Results have demonstrated enhanced learning in a spurt (11 and 19 days of age) and a decrement in learning at a plateau (15 days of age), using an active avoidance task to measure learning in Fuller BWS high and low brain-weight lines. We tested Fuller BWS high-and low-line mice in a passive avoidance task at 11, 15, and 19 days of age. Mice were also tested at 12 days of age, since a recent study found that 12-day-old mice are in a plateau rather than a spurt, as previously reported. As high activity levels may conflict with the response made, activity levels were also measured on the day of testing. The results revealed an age effect and an Age by Line interaction, but no line effect: Mice at 11 and 19 days of age (spurts) differed significantly from mice 15 and 12 days of age (plateaus). Activity was not found to be a confounding measure.Recent work has shown that brain size can be influenced by variables such as nutrition, environment, maternal behavior, and genes (Hahn, Jensen, & Dudek, 1979). It also appears that brain size is related to behavior, as species with larger average brain size in relation to average body size show greater ability to process and utilize information. Epstein (1979) has shown a stagewise growth in average brain weight, and he correlates these braingrowth stages with mind-growth stages, or Piaget's stages of intellectual development. He suggests that the normal course of human brain development is not a linear process but, rather, is characterized by specific stages of rapid and slow growth, or spurts and plateaus, respectively.A study by Gottlieb, Keydar, and Epstein (1977) on mouse and rat brain growth from birth to weaning shows rapid growth (spurts) at 0-6, 8-12 or 13, and 17-23 days, and slow growth (plateaus) at 6-8,12-17, and after 23 days of age. Epstein's (1979) work predicts a decrement in learning ability at a plateau and increased learning in a spurt.

show abstract

“…With relatively small samples the significance of the relationship was not found in all comparisons, but there were no examples of relationships in the opposite direction. The earlier decline of ASV in Lmice is associated with lower weight and slower development of motor skills (Fuller & Herman, 1974) and is consonant with such a hypothesis.…”

Section: Discussionmentioning

confidence: 76%

Effects of maturation and priming on audiogenic seizure thresholds in mice

Fuller

1985

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

The rise and fall of audiogenic seizure vulnerability were followed in three lines of mice selected for brain/body weight ratio and in the heterogeneous stock from which they were derived. Over a period of 12 to 24 days, susceptibility increased and then declined. Subjects retested after a 2-day interval were more susceptible, but this priming effect declined steadily. Differences in seizure threshold varied unsystematically among the lines. No sex differences in susceptibility were found. Mice who seized were heavier on the average than nonseizers of the same age and line. It is proposed that mice with a slower development rate are less susceptible to the stimulus used to evoke seizures. If so, rapid development may tend to lower the threshold of audiogenic seizures in mice.

show abstract

Effect of genotype and practice upon behavioral development in mice

Cited by 42 publications

References 13 publications

Development of learning and memory in mice genetically selected for differences in brain weight

Development of learning and memory in mice genetically selected for differences in brain weight

Passive avoidance during brain-growth spurts and plateaus

Effects of maturation and priming on audiogenic seizure thresholds in mice

Contact Info

Product

Resources

About