Effect of genetic variation in Notch regulator <i>DTX1</i> on SCLC prognosis compared with the effect on NSCLC prongosis

Yoo, Seung Soo; Lee, Jang Hyuck; Hong, Mi Jeong; Choi, Jin Eun; Kang, Hyunwoo; Do, Sook Kyung; Kim, Ji Hyun; Baek, Sun Ah; Choi, Sun Ha; Lee, Won Kee; Lee, Yong Hoon; Seo, Hyewon; Lee, Jaehee; Lee, Shin Yup; Ick, Seung; Kim, Chang Ho; Park, Jae Yong

doi:10.1111/1759-7714.13566

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…In contrast, patients with small cell lung cancer (SCLC) carrying DTX1 mutations showed a worse response to chemotherapy and a lower OS rate, suggesting that mutations in the same gene may play opposite roles in different subtypes of malignant tumors in the same organ. The specific mechanisms underlying these mutations remain to be determined ( Yoo et al, 2020 ).…”

Section: Functions and Associated Molecular Mechanisms Of The Dtx Familymentioning

confidence: 99%

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Wang

Sun

et al. 2021

Front. Cell Dev. Biol.

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Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, comprises five members, namely, DTX1, DTX2, DTX3, DTX3L, and DTX4. The characteristics and functional diversity of the DTX family proteins have attracted significant attention over the last decade. DTX proteins have several physiological and pathological roles and are closely associated with cell signal transduction, growth, differentiation, and apoptosis, as well as the occurrence and development of various tumors. Although they have been extensively studied in various species, data on structural features, biological functions, and potential mechanisms of action of the DTX family proteins remain limited. In this review, recent research progress on each member of the DTX family is summarized, providing insights into future research directions and potential strategies in disease diagnosis and therapy.

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Section: Functions and Associated Molecular Mechanisms Of The Dtx Familymentioning

confidence: 99%

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Wang

Sun

et al. 2021

Front. Cell Dev. Biol.

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“…It has been reported that DTX1 is a potential biomarker for GBM diagnosis (8). Mutations of DTX1 are associated with poor prognosis in patients with small cell (11). In the present study, we explored the associations between DTX1 and BC, and found lower DTX1 could promote BC cell proliferation, migration, and invasion.…”

Section: Discussionmentioning

confidence: 77%

The associations between Deltex1 and clinical characteristics of breast cancer

Liu¹,

Xian²,

Xu³

et al. 2021

Gland Surg

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Background: Deltex 1 (DTX1) is a single transmembrane protein with ubiquitin E3 ligase activity which has been found to play a role in the development of several cancers. We aimed to investigate the associations between DTX1 and breast cancer (BC). Methods:We explored the roles and mechanisms of DTX1 in BC by using BC cell lines in vitro. Levels of DTX1 in serum and tissues were determined in 316 patients with BC, 102 patients with fibroadenoma, and 113 healthy controls by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR). The associations between DTX1 and clinical characteristics of BC were analyzed using multivariate analysis and Cox regression survival analysis.Results: Lower levels of DTX1 promoted BC cell proliferation, migration, and invasion. The cell growth and survival of BC might be regulated by DTX1 via the Notch signaling pathway. Levels of DTX1 in BC tissues were lower compared to fibroadenoma tissues and peri-neoplastic breast tissues (P<0.01). A lower level of DTX1 was shown to be associated with advanced tumor grade (P=0.017), advanced clinical stage (P=0.031), positive lymph node metastasis (LNM) (P=0.009), and high Ki-67 index (P=0.023). Lower DTX1 expression was recognized as an impact factor for metastasis-free survival (MFS) in BC.Conclusions: Lower levels of DTX1 could promote BC cell proliferation and migration, and are associated with advanced BC. There is potential for DTX1 as a marker to assist the selection of new BC treatment.

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Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Cited by 2 publications

References 24 publications

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

The associations between Deltex1 and clinical characteristics of breast cancer

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