Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer

Verde, Zoraida; Santiago, Catalina; Chicharro, Luis Miguel; Reinoso-Barbero, Luis; Tejerina, A.; Bandrés, Fernando; Gómez‐Gallego, Félix

doi:10.3390/ijms17101726

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…Those potential breast carcinogens in tobacco smoke can be taken up and metabolized in humans. In our study, 89 patients took tobacco and 41 patients did not have any addiction to tobacco [10] .In our study we found that among 130 patients 51 patients had ER-/PR-, 19 patients had ER+/PR-, 45 patients had ER+/PR+, 15 patients had ER-/PR+. The Kaplan-Meier survival curve is defined as the probability of surviving in a given length of time while considering time in many small intervals.…”

Section: Discussionsupporting

confidence: 46%

Trastuzumab in Combination with Traditional Chemotherapy is better than Chemotherapy Alone in HER2 Positive Breast Cancer Patients

Uddin¹,

Islam²

2018

TAJ: J of Teachers Assoc

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Breast cancer is one of the most common types of cancer, making up about 25% of all cancer. Despite the high incidence rates, in Western countries, 89% of women diagnosed with breast cancer are still alive 5 years after their diagnosis, which is due to proper detection and treatment. Mainly there are several types of breast cancer. One of the classes is determined by the expression of proteins or receptor and genes. Breast cancer cells may or may not have many different types of receptors, the three most important in the present classification being: estrogen receptor (ER), progesterone receptor (PR), and HER2/neuHER2/neu (human epidermal growth factor receptor 2) receptors. Cells with or without these receptors are called ER positive (ER+), ER negative (ER-), PR positive (PR+), PR negative (PR-), HER2 positive (HER2+), and HER2 negative (HER2-). Cells with negative receptors are called triple negative. Around 25% to 30% of breast cancers show amplification of the HER2 gene. Trastuzumab is a humanized monoclonal antibody targeting the extracellular domain of HER2 receptor. In the metastatic breast cancer setting, Trastuzumab significantly improves overall survival, and is responsible for a change in the natural course of this disease. In this study we have gone to assess the outcome of HER2 positive breast cancer patients with trastuzumab along with cytotoxic chemotherapy in comparison to the conventional chemotherapy. All tumours were tested for HER2/neu status. A randomized control trial was run with 130 patients having HER2 positive breast cancer in Rajshahi Medical College Hospital and different private hospitals and clinics of Rajshahi city in this study.TAJ 2017; 30(1): 30-35

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Section: Discussionsupporting

confidence: 46%

Trastuzumab in Combination with Traditional Chemotherapy is better than Chemotherapy Alone in HER2 Positive Breast Cancer Patients

Uddin¹,

Islam²

2018

TAJ: J of Teachers Assoc

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“…Tobacco smoking is among the main preventable risk factors for several different diseases. The correlation between active tobacco smoking and breast cancer showed an increased risk among women with certain CYP1A1 mutant genotypes ( 18 , 19 ). The interaction between several compounds in tobacco smoke such as polycyclic hydrocarbons and CYP1A1 genotypes has been reported to influence risk of breast cancer ( 20 – 24 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq

Naif

Al‐Obaide

Hassani

et al. 2018

Front. Public Health

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BackgroundCYP1A1 gene polymorphisms and tobacco smoking are among several risk factors for various types of cancers, but their influence on breast cancer remains controversial. We analyzed the possible association of CYP1A1 gene polymorphisms and tobacco smoking-related breast cancer in women from Iraq.Materials and methodsIn this case–control study, gene polymorphism of CYP1A1 gene (CYP1A1m1, T6235C and CYP1A1m2, A4889G) of 199 histologically verified breast cancer patients’ and 160 cancer-free control women’s specimens were performed by using PCR-based restriction fragment length polymorphism.ResultsThree genotype frequencies (TT, TC, and CC) of CYP1A1m1T/C appeared in 16.1, 29.6, and 54.3% of women with breast cancer, respectively, compared with 41.2, 40, and 18.8% in the control group, respectively. CYP1A1m1 CC genotype and C allele were significantly associated with increased risks for breast cancer in patients (54.3 and 69%, respectively) compared with controls (18.8 and 39%, respectively). While the three genotype frequencies (AA, AG, and GG) of CYP1A1m2A/G were detected in 20.1, 31.2, and 48.7% in patients compared with 46.3, 40.6, and 13.1% in controls, respectively. The frequency of GG genotypes and G allele was significantly higher in patients (48.7 and 64%, respectively) than in the controls (13.1 and 33%, respectively). Smoking women having either CC or GG genotypes showed a highly significant association with increased risk of breast cancer [odds ratio (OR) = 1.607, 95% confidence interval (CI) 0.91–1.64, p = 0.0001, and OR, 1.841, 95% CI, 0.88–1.67, p = 0.0001, respectively]. On the other hand, the T and A alleles of predominantly seen in healthy smoking women (83 and 85%, p = 0.0001, respectively).ConclusionThese findings indicated that both C and G alleles of CYP1A1m1 and m2 were significantly associated with elevated risk of breast cancer in Iraqi women, while the T and A alleles were predominantly seen in healthy controls which may indicate their protective role. The C and G association with breast cancer incidence was more prevalent among tobacco smoking patients. These polymorphisms may be used as biomarkers of breast cancer in women from Iraq.

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“…Cigarette smoking (CS) has been identified as the primary risk factor for chronic pulmonary disease initiation (Kopa & Pawliczak, ). CS may lead to the development of diseases including periodontal disease, oral tumor, lung tumor (Kheradmand, You, Hee Gu, & Corry, ; Seifart & Plagens, ; Uppal, Mehndiratta, Mohapatra, Grover, & Puri, ), breast tumor (Verde et al, ), cardiovascular diseases, and asthma (Kovacs et al, ). Somatic mutations may be found in nonmalignant tissues caused by CS (Boran et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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Background Thymine‐DNA glycosylase (TDG) is an essential DNA‐repair enzyme which works in both epigenetic regulation and genome maintenance. It is also responsible for efficient correction of multiple endogenous DNA lesions which occur commonly in mammalian genomes. Research of genetic variants such as SNPs, resulting in disease, is predicted to yield clinical advancements through the identification of sensitive genetic markers and the development of disease prevention and therapy. To that end, the main objective of the present study is to identify the possible interactions between cigarette smoking and the rs4135050 variant of the TDG gene, situated in the intron position, among Saudi individuals. Methods TDG rs4135050 (A/T) was investigated by genotyping 239, and 235 blood specimens were obtained from nonsmokers and smokers of cigarette respectively. Results T allele frequency was found which showed a significant protective effect on Saudi male smokers (OR = 0.64, p = 0.0187) compared to nonsmoking subjects, but not in female smokers. Furthermore, smokers aged less than 29 years, the AT and AT+TT genotypes decreased more than four times the risk of initiation of smoking related‐diseases compare to the ancestral AA homozygous genotype. Paradoxically, the AT (OR = 3.88, p = 0.0169) and AT+TT (OR = 2.86, p = 0.0420) genotypes were present at a higher frequency in smoking patients aged more than 29 years as compared to nonsmokers at the same ages. Conclusion Depending on the gender and age of patients, TDG rs4135050 may provide a novel biomarker for the early diagnosis and prevention of several diseases caused by cigarette smoking.

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Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer

Cited by 8 publications

References 43 publications

Trastuzumab in Combination with Traditional Chemotherapy is better than Chemotherapy Alone in HER2 Positive Breast Cancer Patients

Trastuzumab in Combination with Traditional Chemotherapy is better than Chemotherapy Alone in HER2 Positive Breast Cancer Patients

Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

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