Effect of genetic ancestry to the risk of susceptibility to gastric cancer in a mixed population of the Brazilian Amazon

Abstract

BackgroundGlobal literature describes differences in the incidence of gastric cancer among populations. For instance, Europeans have lower incidence rates of gastric cancer in relation to Latin and Asian populations, particularly Korean and Japanese populations. However, only a few studies have been able to verify the occurrence of gastric cancer in admixed populations with high interethnic degree mix, such as the Brazilian Amazon region.ResultsWe observed an increase in European ancestry in the control group compared to the case group (47% vs. 41%). Using increments of 10%, compared to categorical distribution of European ancestry in the sample, we found a difference in the contribution between cases and controls (p = 0.03). Multiple logistic regression was performed to determine the influence of European ancestry in susceptibility to gastric cancer in the sample. According to the adopted model, for each 10% increase in European ancestry, there is a 20% decrease chance of developing gastric cancer (P = 0.0121; OR = 0.81; 95% CI 0.54–0.83).ConclusionOverall, the results suggest that a greater contribution of European ancestry can be a protective factor for the development of gastric cancer in the studied Amazon population. It can help to establish protocols able to predict susceptibility to gastric cancer in admixed populations.Electronic supplementary materialThe online version of this article (10.1186/s13104-017-2963-4) contains supplementary material, which is available to authorized users.

HLA-B*13, B*35 and B*39 Alleles Are Closely Associated With the Lack of Response to ART in HIV Infection: A Cohort Study in a Population of Northern Brazil

“…Our findings indicate that the allele frequencies of HLA-I and HLA-II were similar to those for heterogeneous populations, especially in the northern region of the country, a finding that was expected given the diversified ethnic influence on regional population structure ( 71 ). In addition, we noted a similarity in the allele frequencies of Caucasoids with the population studied, a finding also observed in other studies of Amazon ancestry profiles ( 72 ). The analyses herein contribute to studies of HLA associations on intra- and interethnic scales and validate our proposal and those of others ( 73 ) specifically for HIV infection, i.e., pathological diversification is a continuous process that is influenced by the genetic profile of the ethnic composition of an infected population ( 74 ).…”

Investigation of INDEL variants in apoptosis: the relevance to gastric cancer

“…Brazil is a country with a highly admixed population, composed mainly of European, African, Amerindian and Asian ancestry. Many studies in this country have highlighted differences between these ancestries and the Brazilian regions [7][8][9][10][11], including aspects of cancer development [12]. This is also notable by the higher incidence of GC in northern Brazil in comparison to the general rates of this country and the world [13].…”

NGF (−198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

“…Although other studies have not identified differences in histological activity and inflammation index between Caucasians and Africans, it is notable that Caucasians had high levels of liver enzymes (Sterling et al, 2004). These results are of particular interest as European ancestry prevails in the Brazilian Amazon population (da Silva et al, 2017). In sum, the results presented indicate that the frequency of NGF and p75 NTR polymorphisms are strictly related to the ethnic population aspects.…”