Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians

Abstract

Background/Objectives: To determine effects of gender, age, diet, and smoking status on circadian rhythm characteristics of ascorbic acid (vitamin C). Subjects/Methods: Ascorbic acid was measured spectrophotometrically in serum collected from 162 healthy volunteers (103 males and 59 females; 7-75 years) every 6 h for 24 h (4 samples). Data were analyzed by single and population mean cosinor. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple analysis of variance. Results: A circadian rhythm is documented with statistical significance by population mean cosinor. In addition to effects of gender and age, the MESOR is affected by diet and smoking status. The circadian amplitude changes nonlinearly as a function of age. The circadian acrophase advances with increasing age. Conclusion:The present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as predisease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

“…It takes part in many reactions and transformations, stimulating various biochemical processes in the body. Because of good solubility of vitamin C and active transport, about 80% is is absorbed by the organism [ 59 , 60 ]. The structure of ascorbic acid, which contains two adjacent groups, hydroxyl and carbonyl, makes this molecule an excellent hydrogen or electron donor, which determines the antioxidant activity.…”

The Contribution of Plasma and Brain Vitamin C on Age and Gender-Related Cognitive Differences: A Mini-Review of the Literature

“…One recent study aimed to assess the effects of gender on serum ascorbate circadian rhythms in humans by collecting serum ascorbate from 162 participants every 6 h for 24 h (Singh et al, 2018 ). Circadian rhythm characteristics including rhythm-adjusted mean (MESOR) and circadian acrophase (timing of overall high ascorbate values recurring each day) were compared between males and females.…”

“…Circadian rhythm characteristics including rhythm-adjusted mean (MESOR) and circadian acrophase (timing of overall high ascorbate values recurring each day) were compared between males and females. However, no gender differences were overserved in these serum circadian rhythm characteristics (Singh et al, 2018 ).…”

“…With increasing age, circadian rhythms tend to fluctuate more, which may influence plasma ascorbate levels. One recent study specifically assessed how aging affects serum ascorbate circadian rhythms by assessing the ascorbate rhythm-adjusted mean (MESOR) and circadian amplitude (Singh et al, 2018 ). The MESOR increased significantly until 46.5 years and the circadian amplitude also started to decrease around 42 years of age.…”

Analisis Determinan Pengeluaran Kesehatan Rumah Tangga Perokok di Sumatera Barat

“…Walaupun rokok dapat menciptakan adrenalin yang tinggi dalam bekerja akan tetapi merokok tetap merupakan perilaku yang merugikan bagi kesehatan, sehingga individu yang aktif merokok atau pun individu yang berada disekitar orang yang merokok sama sama berisiko untuk mengeluarkan biaya untuk kesehatan yang lebih besar. Guo et al, (2007) menemukan bahwa usia berpengaruh positif terhadap pengeluaran kepala rumah tangga untuk kesehatanSelanjutnya hasil penelitian yang dilakukan oleh Walker et al, (2020) serta penelitian Singh et al, (2018) juga menemukan bahwa usia berpengaruh posiif terhadap pengeluaran biaya kesehatan. Hal tersebut terjadi dengan adanya upaya hidup sehat yang dilakukan masyarakat berusia lanjut, karena mereka sangat rentan untuk terdampak Covid 19, walaupun demikian masyarakat yang sudah memiliki kecanduan berat pada rokok mereka akan tetap melakukan pengeluaran yang sama untuk merokok, keadaan tersebut menunjukan terjadi akumulasi biaya yang dikeluarkan baik untuk memenuhi kebutuhan merokok atau pun untuk biaya kesehatan.…”