Effect of gelatin on the swelling behavior of organic hybrid gels based on <i>N</i>‐isopropylacrylamide and gelatin

Lee, Wen‐Fu; Lee, Sung-Chuan

doi:10.1002/app.21287

Cited by 10 publications

(12 citation statements)

References 39 publications

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“…This was interpreted by assuming that the mixing free energy between polymer segments is not a linear function of the solvent composition. Similar behavior was also observed by Tanaka et al, Kim et al, Schild et al, Winnik et al, and in our previous study 29–33…”

Section: Resultssupporting

confidence: 92%

Effect of Biodegradable Cross‐Linkers on the Properties of the Novel Poly(NIPAAm) Hydrogels

Lee¹,

Wang²,

Shen³

et al. 2012

Adv Polym Technol

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ABSTRACT:In this article, a series of biodegradable cross-linkers, [poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,Llactide-co-glycolide), (PLGA-PEG-PLGA), diacrylate] (LGE dA) with different molar ratios of D,L-lactide (LA)/glycolide (GA) in PLGA, were prepared from the corresponding PLGA-PEG-PLGA diol (LGE diol) triblock copolymers and then acrylated with acryloyl chloride. The LGE diols were synthesized through ring-opening polymerization of LA and GA using PEG as an initiator and stannous octoate [Sn(Oct) 2 ] as a catalyst in advance. A series of novel thermosensitive and biodegradable hydrogels were then prepared from N-isopropyl acrylamide (NIPAAm) and LGE dA as a cross-linker. The effect of different molar ratios of LA/GA in PLGA on the swelling ratio and physical properties of the poly(NIPAAm) hydrogels were investigated. The results showed that the swelling ratios of the poly(NIPAAm) hydrogels in deionized EFFECT OF BIODEGRADABLE CROSS-LINKERS ON NOVEL POLY(NIPAAm) HYDROGELSwater decreased with increasing cross-linker content and increased with increasing GA content in the hydrogel. The compressive modulus and cross-linking density of the hydrogels also increased with an increase in the cross-linker content and molar ratio of LA/GA in the present hydrogel. The hydrogels can be degraded about 60% for the NL50 series of gels, but for NL78 about 53% can be degradable in 1-month biodegradable experiment. C 2012 Wiley Periodicals, Inc. Adv Polym Techn 00: 1-18, 2012; View this article online at wileyonlinelibrary.com.

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Section: Resultssupporting

confidence: 92%

Effect of Biodegradable Cross‐Linkers on the Properties of the Novel Poly(NIPAAm) Hydrogels

Lee¹,

Wang²,

Shen³

et al. 2012

Adv Polym Technol

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“…The reason might be that PEGMEA and gelatin are good water absorbents, as well as that full-IPNs usually provide more capacity to reserve the water. For the mechanical properties, the G values of hydrogels synthesized in this study were smaller than those reported [36]. Since G is related to the cross-linking density (ρ), NIPAAm with short and small branches may have led to a more compact structure of IPNs with high cross-linking density.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 54%

“…There have only been a few reports that discuss gelatin-based IPN hydrogels in the last five years; for example, the formation of semi-IPNs from N -isopropylacrylamide (NIPAAm) [36], the formation of full-IPNs from poly(acrylic acid) and gelatin [37], and the formation of full-IPNs from poly(2-hydroxyethylmethacrylate) (poly(HEMA)) and gelatin [38] have been reported. The IPNs based on PEGMEA and gelatin in our current study was full-IPNs.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Drug Release from Interpenetrating Polymer Networks Based on Poly(ethylene glycol) Methyl Ether Acrylate and Gelatin

Ding

Hsu

et al. 2009

Journal of Biomaterials Science, Polymer Edition

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In order to develop new materials for biomedical and pharmaceutical applications, interpenetrating polymer networks (IPNs) based on poly(ethylene glycol) methyl ether acrylate (PEGMEA) and gelatin were synthesized. These two materials were cross-linked sequentially using N,N'-methylene bisacrylamide (NMBA) and glutaraldehyde (Glu). Two series of IPNs gels were synthesized by applying different amounts of PEGMEA and gelatin in the initial feed. Sequential IPNs were prepared by polymerizing and cross-linking PEGMEA in the presence of gelatin using redox initiators (e.g., ammonium peroxydisulfate (APS) and N,N,N',N'-tetramethyl ethylenediamine (TEMED)), as well as NMBA as the cross-linking agent. Gelatin in firm gel was then cross-linked with 1% glutaraldehyde. The swelling kinetics, mechanical properties and drug-release behavior of these IPNs were analyzed. The surface properties were examined by scanning electron microscopy. The results indicated that the swelling ratio decreased with an increase in the content of both PEGMEA and gelatin in the IPNs. PEGMEA/gelatin-based full-IPNs had a significantly higher shear modulus (G) and cross-linking density (rho) when the content of PEGMEA was increased. The drug loading was very high due to the full-IPN structure. The drug-release velocity was mainly affected by the content of PEGMEA.

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“…Gelatin based hydrogels are used in many applications, from ingredient of food preparation to innovative materials and biomaterials. Thermoreversible IPNs were prepared by addition of genipin or glutaraldehide to N-isopropylacrylamide/gelatin mixtures [287]. A rapid swelling/deswelling occurs when the temperature was cycled from The collagen-based materials with complex structures able to rebuild different shaped products, such as membranes, sponges, threads for surgical or dental purposes, and cell culture matrices, are obtained by different physical (electrospinning, molding, or additive manufacturing) or chemical procedures.…”

Section: Gelatinmentioning

confidence: 99%

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Bercea¹

2022

Polymers

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Hydrogels, as interconnected networks (polymer mesh; physically, chemically, or dynamic crosslinked networks) incorporating a high amount of water, present structural characteristics similar to soft natural tissue. They enable the diffusion of different molecules (ions, drugs, and grow factors) and have the ability to take over the action of external factors. Their nature provides a wide variety of raw materials and inspiration for functional soft matter obtained by complex mechanisms and hierarchical self-assembly. Over the last decade, many studies focused on developing innovative and high-performance materials, with new or improved functions, by mimicking biological structures at different length scales. Hydrogels with natural or synthetic origin can be engineered as bulk materials, micro- or nanoparticles, patches, membranes, supramolecular pathways, bio-inks, etc. The specific features of hydrogels make them suitable for a wide variety of applications, including tissue engineering scaffolds (repair/regeneration), wound healing, drug delivery carriers, bio-inks, soft robotics, sensors, actuators, catalysis, food safety, and hygiene products. This review is focused on recent advances in the field of bioinspired hydrogels that can serve as platforms for life-science applications. A brief outlook on the actual trends and future directions is also presented.

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Effect of gelatin on the swelling behavior of organic hybrid gels based on N‐isopropylacrylamide and gelatin

Cited by 10 publications

References 39 publications

Effect of Biodegradable Cross‐Linkers on the Properties of the Novel Poly(NIPAAm) Hydrogels

Effect of Biodegradable Cross‐Linkers on the Properties of the Novel Poly(NIPAAm) Hydrogels

Drug Release from Interpenetrating Polymer Networks Based on Poly(ethylene glycol) Methyl Ether Acrylate and Gelatin

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

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