Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains

Науменко, В. С.; Кондаурова, Е. М.; Базовкина, Д. В.; Цыбко, А. С.; Ilchibaeva, Tatiana V.; Khotskin, Nikita V.; Семенова, А. А.; Попова, Н. К.

doi:10.1016/j.bbr.2014.07.045

Cited by 13 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The administration of GDNF increased expression of D1 and D2 receptor genes in the nucleus accumbens and decreased expression of D1 and D2 receptor genes in the substantia nigra. Genetic variances in GDNF caused the variability of GDNF ‐induced responses and may be responsible for differing GDNF effects . Although there are several widely cited studies on the relationship between BDNF and stress responses, GDNF 's role in stress resilience in humans has still not been clarified.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Genetic variances in GDNF caused the variability of GDNF-induced responses and may be responsible for differing GDNF effects. 49,50 Although there are several widely cited studies on the relationship between BDNF and stress responses, GDNF's role in stress resilience in humans has still not been clarified.…”

Section: Discussionmentioning

confidence: 99%

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

2018

View full text Add to dashboard Cite

show abstract

“…Mature GDNF is known to be an important factor for survival and maintenance of adult DA neurons (Lin et al ., ; Airaksinen & Saarma, ; Bespalov & Saarma, ; Pascual et al ., ). It was also shown that GDNF is able to affect brain both DA (Naumenko et al ., ) and 5‐HT system functioning (Naumenko et al ., ). In this study we revealed significant differences in GDNF level between highly aggressive and nonaggressive rats in 5‐HT and DA brain structures.…”

Section: Discussionmentioning

confidence: 99%

“…Intrastriatal GDNF pretreatment increased tyrosine hydroxylase (TH) phosphorylation in the rat striatum and substantia nigra, which is known to promote TH activity (Salvatore et al ., ). It was shown that central administration of the GDNF caused considerable genotype‐dependent changes in the expression of the key genes of the brain DA system and functional activity of the DA receptors (Naumenko et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Glial cell line‐derived neurotrophic factor in genetically defined fear‐induced aggression

Ilchibaeva

Цыбко

Kozhemyakina

et al. 2016

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Glial cell line-derived neurotrophic factor (GDNF) plays an important role in maintenance of neuronal system throughout life. However, there is a lack of data on the involvement of GDNF in the regulation of different kinds of behavior. In this study, GDNF, its precursor (proGDNF) and GDNF mRNA levels were investigated in the brain of rats selectively bred for 85 generations for either high level or for the lack of affective aggressiveness toward human. It was found that GDNF mRNA level was decreased in the frontal cortex, increased in the raphe nuclei area of the midbrain of aggressive rats compared to tame animals and was not detected in the amygdala and hypothalamus. The level of proGDNF was reduced in the raphe nuclei area of the midbrain of highly aggressive rats and was not detected in the striatum, nucleus accumbens of investigated animals. Two forms of mature GDNF - monomer and dimer - were revealed. GDNF monomer level was increased in the raphe nuclei area, substantia nigra and amygdala of aggressive rats and it was not found in the frontal cortex and nucleus accumbens of investigated rats. Dimer GDNF level was found in all investigated brain structures. It was reduced in the hippocampus and increased in amygdala of highly aggressive rats. Thus, considerable structure-specific differences in GDNF expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of both mature GDNF monomer and dimer as well as proGDNF in the mechanism underlying genetically defined aggressiveness.

show abstract

“…For instance, GDNF heterozygous mutant mice show impaired water-maze learning performance. [61][62][63] Furthermore, GDNF exposure in hippocampal astrocytes led to improved spatial cognitive abilities in aged, cognitively impaired rats. 64 These studies are consistent with our findings.…”

Section: Gfapmentioning

confidence: 98%

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Zhang¹,

Li²,

Zhang³

et al. 2020

NSS

View full text Add to dashboard Cite

The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) change in patients with chronic insomnia disorder (CID), and if this is the case, whether the altered levels of these serum biomarkers are associated with poor sleep quality and cognitive decline in CID. Patients and Methods: Fifty-seven CID outpatients constituted the CID group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography, Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test (NBMT) were used to assess their sleep and neuropsychological function. Serum S100B, GFAP, BDNF, and GDNF were evaluated using enzyme-linked immunosorbent assay. Results: The CID group had higher levels of S100B and GFAP and lower levels of BDNF and GDNF than the HC group. Spearman correlation analysis revealed that poor sleep quality, assessed by subjective and objective measures, was positively correlated with S100B level and negatively correlated with BDNF level. GFAP level correlated positively with poor subjective sleep quality. Moreover, S100B and GFAP levels correlated negatively with general cognitive function assessed using MoCA-C. GFAP level correlated positively with poor spatial working memory (SWM) in the NBMT; BDNF level was linked to poor SWM and object recognition memory (ORcM) in the NBMT. However, principal component analysis revealed that serum S100B level was positively linked to the errors in object working memories, BDNF and GDNF concentrations were negatively linked with errors in ORcM, and GFAP concentration was positively correlated with the errors in the SWM and spatial reference memories. Conclusion: Serum S100B, GFAP, BDNF, and GDNF levels were altered in patients with CID, indicating astrocyte damage, and were associated with insomnia severity or/and cognitive dysfunction.

show abstract

Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains

Cited by 13 publications

References 54 publications

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

Glial cell line‐derived neurotrophic factor in genetically defined fear‐induced aggression

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Contact Info

Product

Resources

About