Effect of Gastrointestinal Symptoms in Patients With COVID-19

Zhou, Zili; Zhao, Ning; Shu, Yan; Han, Shengbo; Чэн, Бин; Shu, Xuefeng

doi:10.1053/j.gastro.2020.03.020

Cited by 220 publications

(228 citation statements)

References 5 publications

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“…According to the clinical investigation of COVID-19 patients, fever and respiratory symptoms predominate [8][9][10] . In addition, a recent study found that digestive symptoms, including abdominal pain, diarrhea, vomiting and nausea, are also present in 26% of COVID-19 patients 11 . Similarly, such digestive problems have been reported in large numbers of SARS and MERS cases 12,13 .…”

Section: Introductionmentioning

confidence: 99%

High Aspartate Aminotransferase to Alanine Aminotransferase Ratio on Admission as Risk Factor for Poor Prognosis in COVID-19 Patients

Qin

Wei

Lyu³

et al. 2020

Preprint

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This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Poor prognosis included death and transfer to other hospitals due to deterioration. Of 567 patients, 56 (9.9%) had AST/ALT ≥ 2. Of the 56 patients, older age (median age 65.5 years), fatigue (29 [51.8%] cases), comorbidities (33 [58.9%] cases) and outcomes were significantly different from patients with AST/ALT < 2. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR = 0.989, 95% CI [0.983-0.996]) were independently associated with AST/ALT ≥ 2 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR = 22.02, 95% CI [1.84-263.2]), especially in patients with AST levels > 40 U/L. In subsequent monitoring, the AST/ALT ratio was decreased in both patients with AST/ALT < 2 or ≥ 2 on admission. COVID-19 patients who are older, or have fatigue, comorbidities are more likely to have AST/ALT ≥ 2 on admission, which might be the indication of worse status and outcomes.

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Section: Introductionmentioning

confidence: 99%

High Aspartate Aminotransferase to Alanine Aminotransferase Ratio on Admission as Risk Factor for Poor Prognosis in COVID-19 Patients

Qin

Wei

Lyu³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…This is complicated by reports of gastrointestinal symptoms in SARS-CoV-2, including in children. 1,2 The management of pediatric appendicitis during this pandemic must be considered in the context of individual hospitals' SARS-CoV-2 testing, bed, staff, and personal protective equipment (PPE) capacity. Hospitals that also care for adults may be strained by SARS-CoV-2 patients while children's hospitals may receive an influx of patients in an attempt to consolidate pediatric care.…”

mentioning

confidence: 99%

Perspectives on Pediatric Appendicitis and Appendectomy During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic

Polites

Azarow

2020

Journal of Laparoendoscopic & Advanced Surgical Techniques

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“…The novel coronavirus showcases the highest SDA among all studied coronaviruses, including lung but also other tissues such as the digestive system and brain. Interestingly, recent reports have shown that COVID-19 patients very frequently have problems in the digestive tract 24,46,47 as well as in neural tissue 23,48,49 .…”

Section: Discussionmentioning

confidence: 99%

Translational adaptation of human viruses to the tissues they infect

Hernandez‐Alias

Schaefer

Serrano

2020

Preprint

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Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of over 500 human-infecting viruses and determine that tropism explains changes in codon usage. Using an in silico model of translational efficiency, we validate the correspondence of the viral codon usage with the translational machinery of their tropism. In particular, we propose that the improved translational adaptation to the upper respiratory airways of the pandemic agent SARS-CoV-2 coronavirus could enhance its transmissibility. Furthermore, this correspondence is specifically defined in early viral proteins, as upon infection cells undergo reprogramming of tRNA pools that favors the translation of late counterparts.

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Effect of Gastrointestinal Symptoms in Patients With COVID-19

Cited by 220 publications

References 5 publications

High Aspartate Aminotransferase to Alanine Aminotransferase Ratio on Admission as Risk Factor for Poor Prognosis in COVID-19 Patients

High Aspartate Aminotransferase to Alanine Aminotransferase Ratio on Admission as Risk Factor for Poor Prognosis in COVID-19 Patients

Perspectives on Pediatric Appendicitis and Appendectomy During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic

Translational adaptation of human viruses to the tissues they infect

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