Effect of gastrin on antroduodenal motility: role of intraluminal acidity

Verkijk, M.; Gielkens, H. A. J.; Lamers, C. B. H. W.; Masclee, Ad

doi:10.1152/ajpgi.1998.275.5.g1209

Cited by 19 publications

(20 citation statements)

References 28 publications

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“…Early human experiments revealed that gastrin administered intravenously relaxed the proximal stomach and stimulated the antral contraction [44,[48][49][50]. Via these functional modulations, gastrin decreases the proximal pressure force and increases the distal occlusive resistance, thereby delaying gastric emptying.…”

Section: Hypergastrinemiamentioning

confidence: 99%

Effects of Proton Pump Inhibitors on Gastric Emptying: A Systematic Review

2009

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The proton pump inhibitor (PPI) is widely used for the treatment of gastroesophageal reflux disease, peptic ulcer diseases, and functional dyspepsia. The pathogenesis of these acid-related and/or functional upper gastrointestinal disorders is potentially associated with abnormal gastric emptying. To date, variable effects of PPIs on gastric emptying have been reported. Therefore, it is relevant to gather and analyze published information on this topic. A systematic literature search has been performed, showing that the delaying effect of PPIs on gastric emptying of solid meals is consistent, whereas the effect of PPIs on the emptying of liquids is inconsistent. The underlying mechanisms whereby PPIs may affect gastric emptying have been discussed, most of which still remain hypothetic. Gastric emptying of solids involves a process of peptic hydrolysis. PPIs impair the hydrolytic digestion by inhibiting acid-dependent peptic activity, thereby delaying the solid emptying. Gastric emptying of liquids largely depends on volume and energy density of intragastric contents. PPIs variably modify the volume and the energy density by reducing gastric fluid secretion, thereby modifying the liquid emptying in an unpredictable manner. Hypergastrinemia has been considered to delay gastric emptying, but it seems of minor importance in the regulation of gastric emptying during PPI use. The delayed emptying of solids due to PPI therapy may have clinical implications in the management of gastroesophageal reflux disease, functional dyspepsia, as well as diabetes.

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Section: Hypergastrinemiamentioning

confidence: 99%

Effects of Proton Pump Inhibitors on Gastric Emptying: A Systematic Review

2009

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“…Infusion of gastrin had no effect on duodenal MMC (Zabielski et al 2004). In human subjects, Verkijk et al (1998) studied the effect of gastrin on the small-intestinal MMC using antroduodenal manometry simultaneous with intraluminal acidity recording. Continuous infusion of gastrin-17 (20 pmol/kg) increased intragastric and intraduodenal acidity and suppressed phase II and phase III motor activity in both antrum and duodenum.…”

Section: Local Effects Of Cholecystokinin and Gastrin In The Gutmentioning

confidence: 99%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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“…From these results we can conclude that duodenal acidification causes relaxation of the proximal stomach. Previous studies in humans have shown the importance of duodenal pH in the regulation of interdigestive gastrointestinal motility 22 –28 . Duodenal acidification inhibits gastric activity by decreasing the antral phase III occurrence rate, while alkalization of the duodenum increases antral phase III occurrence rate 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Duodenal acidification inhibits gastric activity by decreasing the antral phase III occurrence rate, while alkalization of the duodenum increases antral phase III occurrence rate 22 . 25 –27 Recently we have shown that continuous gastrin‐17 infusion suppresses phase II and phase III motor activity in both antrum and duodenum, while during concomitant gastric acid inhibition the effect of gastrin on the MMC is completely antagonized 28 . It is not exactly known how acid in the duodenum elicits its ‘feedback control’ on gastrointestinal motility.…”

Section: Discussionmentioning

confidence: 99%