Effect of garlic (<i>Allium sativum</i> linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol

Kamanna, Vaijinath S.; Chandrasekhara, N.

doi:10.1007/bf02535329

Cited by 72 publications

(36 citation statements)

References 21 publications

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“…Our result was agreement with Kamanna VS, et al [13]. experiment which showed that, the increased levels of LDL-C and cholesterol in animals which fed the hypercholestrolemic diet were partly reversed in mice receiving a supplement of garlic powder.…”

Section: Discussionsupporting

confidence: 93%

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

Mohammadi

Norouzian

Jamshidi

et al. 2009

JAC

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Garlic is one of the medicinal plants, which has shown many useful effects, including Antioxidant activity, hypolipidemic and hypocholesterolemic effects, anti-hypertensive and anti-diabetic effects. Scavenger receptor class B type I (SR-BI) is a cell-surface receptor which mediated selective cholesterol ester uptake from the HDL particle. SR-BI also has an important role in cholesterol absorption in the intestine. Animals were randomly divided into three groups (n=8); group 1: received chow + cholesterol (2%) + cholic acid (0.5%), group 2: chow + 4% (w/w) garlic extract + cholesterol (2%) + cholic acid (0.5%), and group 3: chow only. After one-month mice were sacrificed, blood was collected; lipid profile and blood glucose were determined enzymatically as well as mRNA and protein levels of SR-BI were determined by RT-PCR and westernblot respectively. Compared with hypercholesterolemic control, garlic extract significantly decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, Very Low-Density Lipoprotein-Cholesterol (VLDL-C) and atherogenic index (all of them P<0.05). The activity of Super oxide dismutase(SOD), glutathione (GSH) and catalase levels were markedly increased in garlic-treated animals compared with hypercholesterolemic animals (p<0.05). The plasma levels of MDA markedly reduced in garlic group compared with hypercholesterolemic group. Intestinal SR-BI mRNA and protein were significantly decreased in garlic extract mice treatment compared with hypercholesterolemic control. Levels of liver SR-BI protein significantly reduced in hypercholesterolemic group (P<0.05).In conclusion, garlic extract markedly reduced TC, LDL-C, TG, VLDL-C and atherogenic index, as compared with the hypercholesterolemic control group. On the other hand garlic extract led to down-regulation of SR-BI protein and mRNA in the intestine of mice.

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Section: Discussionsupporting

confidence: 93%

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

Mohammadi

Norouzian

Jamshidi

et al. 2009

JAC

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“…Although the mechanism is not clearly defined, its hypo cholestermic (3)(4)(5)(6) and hypolipidemic (4,6,7) actions have been observed. The addition of garlic to a cholesterol diet lowers plasma lipoprotein levels (3), and garlic also reduces the incorporation of 14C-U-acetate and 14C U-sucrose into the lipid fraction of liver and plasma (8).…”

mentioning

confidence: 99%

Garlic Extract Inhibits the Enhanced Peroxidation and Production of Lipids in Carbon Tetrachloride-Induced Liver Injury

Kagawa

Matsutaka

Yamaguchi

et al. 1986

Japanese Journal of Pharmacology

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Abstract-Carbon tetrachloride (CC14) enhances lipid peroxidation, resulting in triglyceride accumulation in the liver. In this report, we studied the therapeutic, but not the preventive, effect of garlic extract on CC14-intoxicated liver, in comparison to the effect of vitamin E. Garlic extract was given orally to mice in the dose of 10, 100 or 500 mg/kg at 6 hr after CC14 administration.The increased conjugated diene level was diminished significantly to 82% by the 100 mg/kg extract, and also thiobarbituric acid-reactivity was inhibited by all the doses of the extract. In addition to the above mentioned effects, the high doses of garlic extract lowered hepatic triglyceride and lipid contents.Highly significant and positive correlation was observed between hepatic triglyceride content and conjugated-diene level in the lipid fraction of the liver. Besides, vitamin E at the dose of 25 mg/kg inhibited only lipid peroxidation.We, therefore, conclude that not only is garlic extract effective on diminution of lipid peroxide and on alteration of peroxidative status to more reductive condition like the effect of vitamin E, but it also inhibits hepatic triglyceride accumulation in injured liver.

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“…In this respect, 5% garlic powder was more potent (about 19%) than 2.5%. Kamanna et al (1982) and Marta et al (2006) reported a decrease in the serum TC in response to consumption of 2 and 3% garlic powder. They showed that garlic powder made 52 and 33% decrease in serum TC when rats were fed by an atherogenic diet for 8 -9 weeks.…”

Section: Effect Of Garlic Powder On Serum Tgmentioning

confidence: 97%

Alterations in serum lipid, lipoprotein and visceral abdominal fat pad parameters of hypercholestrolemic guinea pigs in response to short term garlic consumption

Pourkabir¹,

Shomali²,

Asadi³

2010

Afr. J. Biotechnol.

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Commercially available garlic preparation in the form of garlic oil, garlic powder and pills are widely used for certain therapeutic purposes, including lowering blood pressure and improving lipid profile. The aim of the present study was to determine short term effects of dietary consumption of garlic on the serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and abdominal fat pad status in hyperlipidemic guinea pigs. 15 animals categorized into three groups of 8 animals each as control, 2.5 and 5% garlic incorporation diet. 2.5 and 5% garlic made significant decrease in serum TG (15 and 29%), TC (73 and 78%), VLDL-C (65 and 70%) and LDL-C (69 and 70%) when compared to the control. However, we have not shown significant changes in the level of serum HDL-C. Moreover, TC concentrations per gram of abdominal fat pad showed 15 and 24% decrease in response to 2.5 and 5% garlic consumption. Garlic consumption decreased mean adipocyte abdominal fat pad (AFP) so that higher percentage of cells was in 0 -5 µm range. Reduction in AFP (50%) and body weight decrease (14%) was shown for garlic groups when compared to the control. The beneficial note of short term dietary consumption of garlic will be done through both serum lipid status and cellular changes of the abdominal fat pad.

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Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol

Cited by 72 publications

References 21 publications

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

Garlic Extract Inhibits the Enhanced Peroxidation and Production of Lipids in Carbon Tetrachloride-Induced Liver Injury

Alterations in serum lipid, lipoprotein and visceral abdominal fat pad parameters of hypercholestrolemic guinea pigs in response to short term garlic consumption

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