2007
DOI: 10.1590/s1806-83242007000100013
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Effect of gamma rays on the bone repair process in rats with estrogen deficiency

Abstract: This study aimed at evaluating the bone repair process in ovariectomized rats submitted to an irradiation procedure. For this purpose, one hundred rats were randomly divided in four experimental groups: control, ovariectomized, irradiated and irradiated/ovariectomized. A bone defect was made on all animals' tibias. Three days after surgery, only irradiated and irradiated/ovariectomized rats received 8 Gy of gamma rays on the lower limbs region. The animals were sacrificed 7, 14, 21 and 28 days after surgery in… Show more

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Cited by 9 publications
(12 citation statements)
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“…The success of the ovariectomy was evaluated by analyzing the estrous cycle, 2 weeks after the surgical procedure [15], and the atrophy of uterine horns during the euthanasia of the animals [16].…”
Section: Ovariectomymentioning
confidence: 99%
“…The success of the ovariectomy was evaluated by analyzing the estrous cycle, 2 weeks after the surgical procedure [15], and the atrophy of uterine horns during the euthanasia of the animals [16].…”
Section: Ovariectomymentioning
confidence: 99%
“…Bone irradiation causes undesirable side effects leading to unfavorable bone remodeling and repair (8)(9)(10)(11) and, in the worst case, osteoradionecrosis (16). In the present study, we exposed cortical bone chips to a gamma radiation dose up to 120 Gy and investigated the subsequent effects on the activity of TGF-β target genes.…”
Section: Discussionmentioning
confidence: 98%
“…Adverse effects include pathologic fractures, continuity defects, and abnormalities in osteosynthesis (8)(9)(10)(11). Substantial evidence indicates that irradiation disrupts bone microvasculature (12,13).…”
Section: Introductionmentioning
confidence: 99%
“…Each animal received an intramuscular injection of 0.1 mL/100 g weight of small‐size veterinary pentabiotic (Fort Dodge ® , Campinas, SP, Brazil), followed by 0.2 mL/100 g of Banamine ® injectable analgesic (Schering‐Plough, Cotia, SP, Brazil). The success of the ovariectomy was evaluated by analyzing the estrous cycle 2 weeks after the surgical procedure and the atrophy of uterine horns observed following the euthanasia of the animals …”
Section: Methodsmentioning
confidence: 99%