Effect of .GAMMA.-oryzanol on serum TSH concentrations in primary hypothyroidism.

Abstract

SynopsisA single oral dose (300mg) of r-oryzanol extracted from rice-bran oil produced a significant reduction on the elevated serum TSH levels in hypothyroid patients. Similarly, chronic treatment with r-oryzanol resulted in decreased serum TSH levels in6of8 patients. There was no change in the serum levels of thyroxine-iodine and triiodothyronine during the study. In addition, there was no difference in the serum TSH response to TRH in hypothyroid patients and normal subjects.These observations suggest that r-oryzanol inhibits serum TSH levels in patients with primary hypothyroidism, possibly by a direct action at the hypothalamus rather than the pituitary.

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

“…The inhibition of luteinizing hormone (LH) secretion after a single intravenous injection was significantly stronger than the inhibition of prolactin releasing hormone (PRL) release in normal male rats and ovariectomized female rats (Yamauchi et al, 1980). A decrease in thyroid stimulating hormone (TSH) production was observed in human patients affected by hypothyroidism both acutely and chronically treated with g-oryzanol 300 mg/day (Shihomura et al, 1980). A single subcutaneous (s.c.) injection of g-oryzanol 20 mg/kg suppressed growth hormone (GH) synthesis and PRL release 1 h after injection.…”

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice

“…γ-Oryzanol is found to cross the blood–brain barrier in intact form and to be distributed highly in the brain [15,16]. Studies of γ-oryzanol in the brain have illustrated its role in modulating the function of the hypothalamus and anterior pituitary gland [17,18,19]. Recently, in a rat model of streptozotocin-induced sporadic Alzheimer’s disease (AD), γ-oryzanol was also reported to preserve memory and cognitive function [20].…”