Effect of Gamma Knife Radiosurgery on Vestibular Schwannoma with Serviceable Hearing: A Single-Center Indian Study

Prabhuraj, A R; Yeole, Ujwal; Arivazhagan, Arimappamagan; Rao, K.V.L. Narasinga; Bhat, Dhananjaya I.; Srinivas, Dwarakanath; Govindswamy, Bhanumathi; Somanna, Sampath

doi:10.1016/j.wneu.2019.02.169

Cited by 5 publications

(17 citation statements)

References 21 publications

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“…Usable hearing loss (change to GR class III, IV or V). Usable hearing loss at 1–3 years, respectively, in the mean cochlear dose group: ≥5 Gy = 7%, 29% and 63% <5 Gy = 0%, 4% and 24% Prabhuraj et al, 2019 15 (India) Retrospective cohort Sample: 77 39 women and 38 men. Age: mean 39.46 (22–67) years.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding exposure, five studies evaluated the mean cochlear radiation dose. 13 , 14 , 15 , 16 , 33 Of these, two additionally assessed the maximum cochlear dose. 14 , 16 Two studies analyzed exposure based only on maximum cochlear dose.…”

Section: Resultsmentioning

confidence: 99%

“… 14 , 16 Two studies analyzed exposure based only on maximum cochlear dose. 11 , 25 The sample was dichotomized in four studies, based on exposure, 13 , 15 , 25 , 33 with divergent cut-off points: mean cochlear dose of 3 Gy (1 study), mean cochlear dose of 5 Gy (1 study), mean cochlear dose of 4 Gy (1 study) and maximum cochlear dose of 4 Gy (1 study).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies used the Gardner–Robertson classification for outcome assessment, considering a decline to classes III, IV or V as loss of usable hearing. 13 , 14 , 15 , 33 Two studies used the PTA difference ≥20 dB 11 , 16 as a criterion for the absence of hearing preservation. One study used the definition of Annual Hearing Decrease Rate (AHDR) to assess the outcome.…”

Section: Resultsmentioning

confidence: 99%

“… 6 , 12 , 13 , 14 There is no consensus regarding the dose limits used in the studies that found a positive correlation. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 …”

Section: Introductionmentioning

confidence: 99%

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Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review

Cavalcanti,

Lemos,

Moretti

et al. 2023

Brazilian Journal of Otorhinolaryngology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“… 6 , 12 , 13 , 14 There is no consensus regarding the dose limits used in the studies that found a positive correlation. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review

Cavalcanti,

Lemos,

Moretti

et al. 2023

Brazilian Journal of Otorhinolaryngology

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Outcomes of stereotactic radiosurgery in young adults with vestibular schwannomas

et al. 2021

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Purpose: Vestibular schwannomas (VSs) are comparatively rare in younger patients, and stereotactic radiosurgery (SRS) outcome data are limited. We aimed to evaluate long-term SRS outcomes concerning sporadic VSs in patients aged ≤ 40 years. Methods: Of 383 patients with VS who had undergone SRS at our institution between 1990 and 2017, we compared younger and older patients' tumor control and radiation-induced complication rates using case-control propensity score (PS) matching.Results: The mean follow-up was 83 and 92 months in older and younger patients, respectively.Compared with older patients, younger patients were more likely to have a history of resection (20% vs. 39%, p = 0.006) and be treated with higher marginal doses (median, 12 Gy vs. 14 Gy; p = 0.014).Cumulative 5-and 10-year tumor control rates were higher in older patients (97.7% and 93.9%, respectively) than in younger patients (90.2% and 85.4%, respectively, p = 0.024). After PS matching, younger patients' cumulative tumor control rates (93.6%, 85.4%, and 85.4% at 5, 10, and 15 years, respectively) were similar to those of older patients (p = 0.411). No signi cant between-cohort differences in hearing preservation rates or facial and trigeminal nerve complications were observed. Two younger patients had malignant tumors several years post-SRS, with one patient having con rmed histological transformation.Conclusions: SRS is equally effective for younger and older patients. Complications other than hearing deterioration are uncommon. Malignant transformation is possible and long-term post-SRS surveillance MRI is important. These data are useful for decision-making involving young adults with VSs.

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The Effect of Cochlear Dose on Hearing Preservation After Low-Dose Stereotactic Radiosurgery for Vestibular Schwannomas: A Systematic Review

Govindaraj

Khong²,

Byrne³

et al. 2022

Advances in Radiation Oncology

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Effect of Gamma Knife Radiosurgery on Vestibular Schwannoma with Serviceable Hearing: A Single-Center Indian Study

Cited by 5 publications

References 21 publications

Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review

Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review

Outcomes of stereotactic radiosurgery in young adults with vestibular schwannomas

The Effect of Cochlear Dose on Hearing Preservation After Low-Dose Stereotactic Radiosurgery for Vestibular Schwannomas: A Systematic Review

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