2014
DOI: 10.1007/978-1-4939-1396-1_26
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Effect of Galectins on Viral Transmission

Abstract: Recent reports suggest that some galectins bind to enveloped viruses. They include influenza virus, human immunodeficiency virus-1 (HIV-1), human T-cell leukemia virus-1 (HTLV-1), and Nipah virus. It is also suggested that the interaction between viruses and galectins influences viral attachment to their susceptible cells, affecting the viral infectivity. Our work suggests that galectin-1 increases the infectivity of HIV-1 and HTVL-1. Indeed, galectin-1 promotes the initial adsorption of HIV-1 to CD4(+) cells … Show more

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Cited by 6 publications
(3 citation statements)
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“…Within the complexes, both LNT and LNnT adopt an extended linear conformation very similar to that observed in the P[11] VP8*, suggesting a manner in which the core LNT and LNnT structures bound by VP8* could engage both galectins and P[11] VP8. Other studies have suggested that galectins may be exploited for transmission and replication of viruses, such as influenza viruses, HIV and Nepah viruses 37 38 . Clearly, the possible role of galectins and their ligands in affecting the cell entry and replication of RVs needs further studies.…”
Section: Discussionmentioning
confidence: 99%
“…Within the complexes, both LNT and LNnT adopt an extended linear conformation very similar to that observed in the P[11] VP8*, suggesting a manner in which the core LNT and LNnT structures bound by VP8* could engage both galectins and P[11] VP8. Other studies have suggested that galectins may be exploited for transmission and replication of viruses, such as influenza viruses, HIV and Nepah viruses 37 38 . Clearly, the possible role of galectins and their ligands in affecting the cell entry and replication of RVs needs further studies.…”
Section: Discussionmentioning
confidence: 99%
“…Galectin-1. It was postulated that galectin-1 increases HIV-1 infectivity of T cells and macrophages through a mechanism involving an initial interaction with gp120 (Ouellet et al 2015 ). Galectin-1 is the only galectin studied in the presence of illicit drugs (Reynolds et al 2012a , b ).…”
Section: Discussionmentioning
confidence: 99%
“…Recombinant Gal-1 (rGal-1) and Gal-3 production Recombinant (r) Gals were purified as previously described with minor modifications (61)(62)(63)(64)(65). Briefly, Terrific Broth containing ampicillin was inoculated with Escherichia coli BL21 (DE3), which carries the expression plasmid of either human Gal-1 or human Gal-3 [kindly provided by Dr. Jun Hirabayashi and Dr. Kenichi Kasai (Teikyo University, Tokyo, Japan)], and incubated overnight at 37°C.…”
Section: Primary Cells and Cell Linesmentioning
confidence: 99%