Effect of Gabexate Mesilate on Thrombin and Plasmin Generation after Hepatic Resection in Cirrhotic Patients

Abstract

The effect of the gabexate mesilate (Gab) on thrombin and plasmin generation following liver resection in cirrhotic patients was studied. Six cirrhotic patients received an infusion of Gab after liver resection (Gab group), and another 6 patients did not receive such treatment (Con group). The parameters measured were thrombin-antithrombin complex (TAT), plasmin-antiplasmin complex (PAP) and D-dimer. The real increases of D-dimer and PAP were significantly higher in Con group after surgery while no significant difference was observed in the increase of TAT. These results show that Gab suppresses plasmin generation and following D-dimer production more effectively than thrombin generation after hepatic resection.

Diabetes mellitus as a Risk Factor for Glaucomatous Optic Neuropathy

“…These changes include accelerated apoptosis of retinal inner neurons [48, 49, 50], altered expression of glial fibrillary acidic protein (GFAP) in two macroglial cells (astrocytes and Müller cells) [51, 52, 53, 54], activated microglia [50], and impaired glutamate metabolism [52, 55, 56, 57]. These altered neuroglial functions, in fact, have been clinically acknowledged by prolonged latencies of oscillatory potentials on the ERG b wave [58, 59, 60, 61, 62, 63, 64, 65, 66, 67], deficits in contrast sensitivity [68, 69, 70, 71]and color vision [72, 73, 74, 75, 76], and nerve fiber layer defects, which were observed by green filter photography in earlier studies [77, 78]and recently by scanning laser polarimetry [79]. Histologically, as early as the 1960s, Wolter [80]and Bloodworth [81]found pyknotic configurations of neuronal cells in retinas of postmortem eyes from patients with diabetes.…”

Systematic review of randomized controlled trials of pharmacological interventions to reduce ischaemia-reperfusion injury in elective liver resection with vascular occlusion

“…No references were identified through scanning reference lists of the identified RCTs. Of the 48 references, 24 were excluded as they represented non‐randomized studies, 30–43 a quasi‐randomized study which did not report adverse outcomes related to the pharmacological intervention, 44 a protocol of a study 45 or studies that did not use vascular flow occlusion during liver resection 46–53 . A total of 24 references describing 18 RCTs fulfilled the inclusion criteria 54–77 .…”