Effect of GABA-positive substances on stimulation of uterine contractions by excitatory neurotransmitters, prostaglandin F2?, and oxytocin

Sizov, P. I.

doi:10.1007/bf00840938

Cited by 3 publications

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“…51,91 Thus, it is shown that agonist seduksen benzodiazepine receptors having GABA-ergic mechanisms as the other GABA-positive substances are physiological antagonists of norepinephrine, serotonin, melatonin, oxytocin and prostaglandin F2α by the action on the uterus. 75,[105][106][107][108] Thus, increased in the last decade, the interest of researchers to study the physiological role of melatonin in the reproductive function has given sufficient evidence not only his chronotropic activity, but also a number of other pharmacologically valuable properties that determine the optimal course of pregnancy and childbirth, making a promising development of new approaches to its use in obstetrics. At the same time, existing data indicate the need for special attention to keeping in obstetric hospitals light conditions needed for the endogenous production of melatonin, as well as restrictions on the use of its suppressive drugs.…”

Section: Introductionmentioning

confidence: 99%

In Melatonin: pregnancy and childbirth

Karpovitch

Inna

Moiseevich

2018

MOJCRR

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Section: Introductionmentioning

confidence: 99%

In Melatonin: pregnancy and childbirth

Karpovitch

Inna

Moiseevich

2018

MOJCRR

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Experimental validation for a clinical study of GABA-positive substances in threatened abortion

et al. 1994

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The barouterography method revealed that intravenous phenibut in a dose of 50 mg/ kg and phenazepam in a dose of 2.5 mg/kg have a suppressive effect on the contractile isometric (fetus-expelling) activity of the uterus in nonpregnant and pregnant rabbits. Phenibut (150 mg/kg) and phenazepam (3 mg/kg) do not have an adverse effect on fetal development in rats. Clinical trials of phenibut and phenazepam as gravidoprotectors in threatened abortions are recommended.

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Metabolomics-Coupled Functional Pharmacology of Chlorophyll Compounds Isolated From the Leaves of Ficus Exasperata Vahl (Moraceae) Provides Novel Pathways on Myometrial Activity

2018

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New chlorophyll derivatives (pheophytins along with pheophorbide derivatives) were isolated from the leaves of Ficus exasperata and were found to have varying effects on uterine contractility. The current study was therefore aimed at the utilization of mass spectrometry and nuclear magnetic resonance spectroscopy coupled with isolated uterine tissue assay as a platform to assist in the determination of the mechanism of activity of the isolated chlorophyll compounds from the plant F exasperata. The pheophytin and pheophorbide compounds (200 µg/mL) were added to the isolated uterine tissues. Mice uteri, treated with the pheophytin compounds, and the physiological buffer in which the uterine tissues were immersed, were rapidly collected and analyzed using high-resolution Fourier transform mass spectrometry and proton (H) nuclear magnetic resonance for bioinformatics study. Resulting data were analyzed via pairwise chemometric comparison models, with P < .05 considered statistically significant. Primary signaling pathways found to be correlated with the pheophytins in this study included cyclic adenosine monophosphate, dopamine, extracellular signal-regulated kinases 1/2, and glutamate pathways.

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Effect of GABA-positive substances on stimulation of uterine contractions by excitatory neurotransmitters, prostaglandin F2?, and oxytocin

Cited by 3 publications

References 0 publications

In Melatonin: pregnancy and childbirth

In Melatonin: pregnancy and childbirth

Experimental validation for a clinical study of GABA-positive substances in threatened abortion

Metabolomics-Coupled Functional Pharmacology of Chlorophyll Compounds Isolated From the Leaves of Ficus Exasperata Vahl (Moraceae) Provides Novel Pathways on Myometrial Activity

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