Effect of fullerenol nanoparticles on oxidative stress induced by paraquat in honey bees

Kojić, Danijela; Purać, Jelena; Čelić, Tatjana V.; Vukašinović, Elvira L.; Pihler, Ivan; Borišev, Ivana; Djordjević, Aleksandar

doi:10.1007/s11356-019-07385-z

Cited by 15 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiments, we tested the enzyme activity in erythrocytes subjected to oxidative stress induced by prolonged incubation, in the presence of C 60 (OH) 36 . Fullerenes are an important class of nanomaterials with a wide potential applicability in biomedical sciences [8], and their water-soluble derivatives (fullerenols) are promising candidates for use as antioxidants in biological systems [10][11][12][13][14][15][16][17]. C 60 (OH) 36 prevents ROS cell damage, but also can scavenge NO [13,20,21,38].…”

Section: Discussionmentioning

confidence: 99%

“…Fullerenes and their derivatives are considered effective free radical scavengers, including ROS, based on the large number of conjugated double π bonds [ 8 ]. Their water-soluble derivatives C 60 (OH) n (fullerenols) have recently been the subject of numerous investigations regarding the radioprotective and antioxidant properties in biological and biomimetic systems [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Covalently attached hydroxyl groups play a crucial role for the localization of fullerenol and its accessibility for ROS, whereas the mechanism of antioxidant action of C 60 (OH) n depends on the nature of ROS [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes

Grebowski

Kazmierska-Grebowska

Cichoń

et al. 2021

IJMS

View full text Add to dashboard Cite

Background: Fullerenols (water-soluble derivatives of fullerenes), such as C60(OH)36, are biocompatible molecules with a high ability to scavenge reactive oxygen species (ROS), but the mechanism of their antioxidant action and cooperation with endogenous redox machinery remains unrecognized. Fullerenols rapidly distribute through blood cells; therefore, we investigated the effect of C60(OH)36 on the antioxidant defense system in erythrocytes during their prolonged incubation. Methods: Human erythrocytes were treated with fullerenol at concentrations of 50–150 µg/mL, incubated for 3 and 48 h at 37 °C, and then hemolyzed. The level of oxidative stress was determined by examining the level of thiol groups, the activity of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase), and by measuring erythrocyte microviscosity. Results: The level of thiol groups in stored erythrocytes decreased; however, in the presence of higher concentrations of C60(OH)36 (100 and 150 µg/mL), the level of -SH groups increased compared to the control. Extending the incubation to 48 h caused a decrease in antioxidant enzyme activity, but the addition of fullerenol, especially at higher concentrations (100–150 µg/mL), increased its activity. We observed that C60(OH)36 had no effect on the microviscosity of the interior of the erythrocytes. Conclusions: In conclusion, our results indicated that water-soluble C60(OH)36 has antioxidant potential and efficiently supports the enzymatic antioxidant system within the cell. These effects are probably related to the direct interaction of C60(OH)36 with the enzyme that causes its structural changes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes

Grebowski

Kazmierska-Grebowska

Cichoń

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Several persistent organic pollutants (including explosive residues) originating from industrial and urban activities have also been isolated from bee samples and evaluated (Garcia-Valcarcel et al 2016;Drummond et al 2017;Simic et al 2019;Gómez-Ramos et al 2019). More recently, nanomaterials and nanoparticles have been added to the list of contaminants that honeybees can be used to monitor in the environment (Milivojevic et al 2015;Kojic et al 2020;Hooven et al 2019;Glavan et al 2017).…”

Section: Current Applications Of Biomonitoring Using Honeybeesmentioning

confidence: 99%

“…Their spread across urban and rural areas has already put them into contact with honeybees. The toxic, or sometimes even beneficial, characteristics of nanomaterials such as ZnO, fullerenol, nanotechnology-based pesticides, and silver nanoparticles coupled to plant extracts have been investigated (Milivojevic et al 2015;Kojic et al 2020;Hooven et al 2019). The present studies were based on the particular adaptation of the pollinator to collect pollen, and then on the assumption that any other types of environmental particles can also be actively gathered by bees.…”

Section: Explosives Nanoparticles and Other Organic Pollutantsmentioning

confidence: 99%

Bioindicators and biomonitoring: honeybees and hive products as pollution impact assessment tools for the Mediterranean area

Girotti

Ghini

Ferri

et al. 2020

Euro-Mediterr J Environ Integr

View full text Add to dashboard Cite

The global range of the environmental quality issues we all face necessitates integrated action from all of the countries that suffer from a particular environmental issue. We must be able to obtain data on the presence of pollutants and their effects on biota from any territory, regardless of its environmental, infrastructural, social, and economic conditions. Biomonitoring utilizes organisms and natural materials to obtain this information. In particular, the honeybee is a ubiquitous, easy-to-breed organism with great mobility. Its body, which is covered with hairs, picks up materials and particulates that it encounters in the environment. Therefore, bees are highly effective accumulators of materials from the soil, vegetation, air, and water. These characteristics mean that the honeybee is both a bioindicator and a passive bioaccumulator organism, making it an ideal agent for easily monitoring vast areas inexpensively, even in regions where infrastructure is scarce. In this short review, we summarize the main targets of the honeybee-based monitoring campaigns that have been carried out to date, highlighting the results obtained in assessments of organic and inorganic pollution performed by coupling more modern technologies with this long-standing practice. It is hoped that this review will make scientists more aware of the incredible potential of these delicate organisms to provide data that could prove useful in the management of environmental issues.

show abstract

“…It is widely used in various scientific disciplines due to its stability and ability to easily bind and release electrons, as well as its optical properties [ 8 ]. Unfortunately, pristine fullerene is practically insoluble in water (0.1 ng/L) and numerous investigations have been conducted to obtain functionalized, water-soluble derivatives and determine their effects on living systems [ 9 ]. The discovery of fullerols, C 60 (OH) 24 , a water-soluble molecule and the first fullerene derivative formed by symmetrical attachment of the 12–48 hydroxyl groups, solved this problem ( Figure 1 f).…”

Section: Introductionmentioning

confidence: 99%

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Subotić

Jevremović

Milošević

et al. 2022

Plants

View full text Add to dashboard Cite

The rapid production and numerous applications of nanomaterials warrant the necessity and importance of examining nanoparticles in terms to their environmental and biological effects and implications. In this study, the effects of a water-soluble hyper-harmonized hydroxyl-modified fullerene (3HFWC) on cherry tomato seed germination, seedlings growth, physiological response and fruiting was evaluated. Changes in the photosynthetic pigments content, oxidative stress assessment, and aquaporin genes expression in cherry tomato plants were studied after during short- and long-term continuous exposure to 3HFWC nanosubstance (200 mg/L). Increased levels of photosynthetic pigments in leaves, lycopene in fruits, decreased levels of hydrogen peroxide content, activation of cellular antioxidant enzymes such as superoxide dismutase, catalase and peroxidase and increased aquaporin gene expression (PIP1;3, PIP1;5 and PIP2;4) were observed in 3HFWC nanosubstance-exposed plants in comparison to control, untreated cherry tomato plants. The 3HFWC nanosubstance showed positive effects on cherry tomato seed germination, plantlet growth and lycopene content in fruits and may be considered as a promising nanofertilizer.

show abstract

Effect of fullerenol nanoparticles on oxidative stress induced by paraquat in honey bees

Cited by 15 publications

References 48 publications

The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes

The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes

Bioindicators and biomonitoring: honeybees and hive products as pollution impact assessment tools for the Mediterranean area

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Contact Info

Product

Resources

About