Effect of fucoidan on aspirin-induced stomach ulceration in rats

Choi, Jong-il; Raghavendran, Hanumatha Rao Balaji; Sung, Nak-Yun; Kim, Jae‐Hun; Chun, Byeong Soo; Ahn, Dong Hyun; Choi, Hongseok; Kang, Keon Wook; Lee, Ju-Woon

doi:10.1016/j.cbi.2009.09.015

Cited by 101 publications

(66 citation statements)

References 23 publications

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“…Then, the alteration of hepatic biochemical biomarkers by aspirin could be explained by an increase in plasma membrane permeability or cellular necrosis causing enzymes to leak into the blood stream 38 . These findings are in agreement with those reported by Choi et al 37 who…”

Section: Discussionsupporting

confidence: 94%

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

et al. 2016

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Section: Discussionsupporting

confidence: 94%

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

et al. 2016

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“…Previous studies have demonstrated that the levels of TNF-α and IL-6 markedly increased in the gastric tissue of ethanol-induced ulcer because ethanol ingestion may activate the innate immune system leading to the release of the pro-inflammatory cytokines [18,19,22]. TNF-α, a representative inflammatory cytokine with pleiotropic functions, is involved in the induction of inflammation, injury, and carcinogenesis in a variety of tissues [32].…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal problems have now become a global problem, and the gastric ulcer model induced by ethanol in mice is usually used to assess the gastroprotective activity of the drugs [17]. It has been reported that some pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are involved in the pathogenesis of acute gastric lesions [18,19,20]. Nuclear factor-kappa B (NF-κB) is a classic pro-inflammatory transcription factor and plays a central role in regulating inflammatory, immune, and anti-apoptotic processes.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Sun¹,

Liu

et al. 2017

Pharmacology

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Aim: This study was designed to develop sanguinarine-loaded solid lipid nanoparticles (SG-SLNs) and investigate its gastroprotective effect on ethanol-induced gastric mucosal lesions in mice. Methods: SG-SLNs were prepared by high temperature melt-cool solidification method using glycerol monostearate as the lipid and a combination of lecithin with poloxamer 188 as the surfactants. Solid lipid nanoparticles (SLNs) were designed at varying lipid concentrations (5, 10, 15, and 20 mg/mL), surfactant mixture concentrations (6, 12, and 18 mg/mL), and drug contents (5, 10, 15, and 20 mg/mL) in “one factor at a time” fashion. Ethanol-induced gastric ulcer model was performed on Kunming mice to examine the anti-inflammatory activity of SG-SLNs and compare it with sanguinarine (SG). Results: The high temperature melt-cool solidification method provided consistent production of SLNs with smaller size and high entrapment efficiency (EE%). The composition of optimal formulation was 10 mg/mL lipid concentration, 18 mg/mL surfactant mixture concentration, and 15 mg/mL drug amount. The mean particle size and EE% of optimized formulation were 238 ± 10.9 nm and 79 ± 2.8%, respectively. Additionally, SG-SLNs significantly decreased tumor necrosis factor-alpha and interleukin-6 levels in the serum and gastric tissue, and reduced the content of NO in serum, and strengthened the protection of mucosal membrane. Moreover, SG-SLNs treatment markedly inhibited ethanol-induced nuclear factor-kappa B (NF-κB) activation when compared with SG. Conclusions: SLNs could be potentially applied as a delivery system of SG. The protective effect of SG-SLNs is due to the suppression of NF-κB expression and subsequent pro-inflammatory cytokines release.

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“…Recently, substantial research has been carried out on the medical benefits of fucoidan and a wide range of biological activities has been reported. Choi et al [11] indicated that fucoidan protects the gastric mucosa from inflammatory cytokine-mediated oxidative damage in rats. Hayashi et al [6] reported that fucoidan reduces CCl4-induced acute and chronic liver failure with hepatic fibrosis and anti-inflammatory activity of fucoidan has been demonstrated in rats [12].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer

Ikeguchi¹,

Saito²,

Miki³

et al. 2015

JCT

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In Japan, S-1 plus cisplatin has become a standard regimen for the treatment of unresectable advanced gastric cancer; however, many patients are unable to continue effective chemotherapy because of the regimen's severe side effects. Thus, control of drug toxicity is key to prolonging patient survival. Fucoidan is a major sulfated polysaccharide found in brown seaweeds and has a wide range of biological activities. In the present study, we analyzed the effect of fucoidan on suppressing the toxicity of chemotherapy drugs. Twenty-four patients with unresectable advanced gastric cancer underwent treatment with S-1 plus cisplatin and were randomly allocated into a fucoidan treatment group (n = 12) or a control group without fucoidan treatment (n = 12). The study results demonstrated that fucoidan controlled the occurrence of fatigue during chemotherapy and patients could continue chemotherapy for longer time periods by maintaining the patients' favorable nourishment status. As a result, the survival of patients with fucoidan treatment was longer than that of patients without fucoidan. Thus, fucoidan should be included as a key food supplement for patients with gastrointestinal carcinomas who are suffering from the adverse side effects of chemotherapy.

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Effect of fucoidan on aspirin-induced stomach ulceration in rats

Cited by 101 publications

References 23 publications

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer

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