Effect of Freezing on Oxytocin Ampules

Nassta, Gemma; Prankerd, Richard J.; McIntosh, Michelle Paula

doi:10.1056/nejmc1209761

Cited by 25 publications

(3 citation statements)

References 52 publications

(67 reference statements)

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“…Oxytocin needs to be stored under refrigeration (2–8°C) as much as possible, although short periods of unrefrigerated transport not exceeding 1 month at 30°C or 2 weeks at 40°C, are acceptable . Oxytocin should also not be frozen, although recent evidence suggests that multiple cycles of freezing and thawing do not significantly change oxytocin content . Although several studies and reports have assessed the quality of oxytocin in LMIC, their findings have not been analysed or synthesised.…”

Section: Introductionmentioning

confidence: 99%

Quality of oxytocin available in low‐ and middle‐income countries: a systematic review of the literature

Torloni

Freitas

Kartoglu

et al. 2016

BJOG

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Background Oxytocin is the drug of choice for preventing and treating postpartum haemorrhage, an important cause of maternal death. Oxytocin is widely available in low and middle-income countries (LMIC) but there are concerns about its quality.Objective To identify, critically appraise and synthesise the findings of studies on the quality of oxytocin available in LMIC.Search strategy We searched seven electronic databases, without language restriction.Selection criteria Studies reporting results of tests to assess quality of oxytocin samples from LMIC.Data collection and analysis Study selection, data extraction and quality assessment were performed in duplicate. Results are presented descriptively.Main results The search identified 2611 unique citations; eight studies, assessing 559 samples from 15 different countries were included. Most samples were collected from facility level settings (n = 509) and from the private sector (n = 321). The median prevalence of oxytocin samples that failed quality tests was 45.6% (range 0-80%), mostly due to insufficient amounts of active pharmacological ingredient. Over one-third of the samples (n = 204) had low (<90%) oxytocin content indicating substandard medicine; two samples had no active ingredient, suggesting possible counterfeit drugs. The proportion of low fails was higher in samples collected in Africa than in Asia or Latin America (57.5% versus 22.3% versus 0%, respectively, P < 0.0001), in private than in public sectors (34.0% versus 25.3%, P = 0.032) and in facilities than in central distributors (37.9% versus 22.0%, P = 0.030). ConclusionThere is a high prevalence of poor-quality oxytocin samples in LMIC countries, mainly due to inadequate amounts of active ingredient.

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Section: Introductionmentioning

confidence: 99%

Quality of oxytocin available in low‐ and middle‐income countries: a systematic review of the literature

Torloni

Freitas

Kartoglu

et al. 2016

BJOG

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“…Therapeutic interventions that manipulate the microbiota such as prebiotics, probiotics (live microorganisms), and fecal microbiota transplantation (FMT; infusing intestinal microbiota from lean donor) may have benefits in improving glucose metabolism and insulin resistance in the host [101, 104–108]. FMT in humans with metabolic syndrome has beneficial effects on the recipients' microbiota composition (increase in SCFA-producing bacteria), with a concomitant improvement in insulin sensitivity [109].…”

Section: Perspectivesmentioning

confidence: 99%

Mesenchymal Stem Cells as Therapeutic Candidates for Halting the Progression of Diabetic Nephropathy

Paulini

Higuti

Bastos

et al. 2016

Stem Cells International

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Mesenchymal stem cells (MSCs) possess pleiotropic properties that include immunomodulation, inhibition of apoptosis, fibrosis and oxidative stress, secretion of trophic factors, and enhancement of angiogenesis. These properties provide a broad spectrum for their potential in a wide range of injuries and diseases, including diabetic nephropathy (DN). MSCs are characterized by adherence to plastic, expression of the surface molecules CD73, CD90, and CD105 in the absence of CD34, CD45, HLA-DR, and CD14 or CD11b and CD79a or CD19 surface molecules, and multidifferentiation capacity in vitro. MSCs can be derived from many tissue sources, consistent with their broad, possibly ubiquitous distribution. This article reviews the existing literature and knowledge of MSC therapy in DN, as well as the most appropriate rodent models to verify the therapeutic potential of MSCs in DN setting. Some preclinical relevant studies are highlighted and new perspectives of combined therapies for decreasing DN progression are discussed. Hence, improved comprehension and interpretation of experimental data will accelerate the progress towards clinical trials that should assess the feasibility and safety of this therapeutic approach in humans. Therefore, MSC-based therapies may bring substantial benefit for patients suffering from DN.

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“…Only one patient was coinfected with human immunodeficiency virus (HIV). Each of the 16 serum samples was divided into seven subsets: three subsets were stored for 1 week on crushed ice, at −20°C or at −80°C respectively; three subsets were stored for 1 week at the same temperatures, but the samples were exposed to five freeze-thaw cycles (FTCs); and one subset was maintained at 4°C for 4 weeks [Nassta et al 2013]. The levels of serum IgM anti-CL antibodies were determined for each sample using a modification of a previously described in-house enzyme-linked immunosorbent assay (ELISA) [Goodridge et al 2012].…”

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confidence: 99%

Storage in ultra-low-temperature decreases the levels of IgM anticardiolipin antibody in serum samples from tuberculosis patients

Weeks-Galindo

Goodridge

2014

Ther Adv Respir Dis

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The evaluation of novel tuberculosis (TB) biomarkers relies on analysis of previously stored sample sets. We aimed to determine the effect of storage temperature on serum IgM anticardiolipin antibody levels in samples from TB patients. Ultra-low-temperature storage decreased IgM anticardiolipin levels. We recommend against using ultra-low-temperature storage when investigating IgM anticardiolipin biomarker-based tests.

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Effect of Freezing on Oxytocin Ampules

Cited by 25 publications

References 52 publications

Quality of oxytocin available in low‐ and middle‐income countries: a systematic review of the literature

Quality of oxytocin available in low‐ and middle‐income countries: a systematic review of the literature

Mesenchymal Stem Cells as Therapeutic Candidates for Halting the Progression of Diabetic Nephropathy

Storage in ultra-low-temperature decreases the levels of IgM anticardiolipin antibody in serum samples from tuberculosis patients

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